Eugenia Quirós-Roldán
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View article: Actinic Keratosis and Human Papillomaviruses: may their relationship constitute a new approach for actinic keratosis management?
Actinic Keratosis and Human Papillomaviruses: may their relationship constitute a new approach for actinic keratosis management? Open
Actinic keratosis (AK) is a precancerous lesion that typically develops on photo-damaged skin, particularly in older adults and immunocompromised individuals. Due to its high prevalence and its potential to progress to cancer, AK has becom…
View article: Effectiveness of first-line lamivudine/dolutegravir antiretroviral therapy in persons with HIV: real-life data from the ICONA Foundation cohort
Effectiveness of first-line lamivudine/dolutegravir antiretroviral therapy in persons with HIV: real-life data from the ICONA Foundation cohort Open
Objectives This analysis aimed to evaluate the rate of failure of first-line lamivudine/dolutegravir in a real-world setting and assess the effectiveness among people with HIV (PWH) at higher risk of suboptimal response. Methods The study …
View article: ATYPICAL DERMATOLOGICAL MANIFESTATIONS OF SYPHILIS IN ADVANCED HIV: A CASE-BASED NARRATIVE REVIEW
ATYPICAL DERMATOLOGICAL MANIFESTATIONS OF SYPHILIS IN ADVANCED HIV: A CASE-BASED NARRATIVE REVIEW Open
Syphilis is re-emerging globally, particularly among people living with HIV. Secondary syphilis classically presents with a maculopapular rash involving the trunk and extremities, but atypical cutaneous manifestations are increasingly reco…
View article: Novel and repurposed antiviral molecules for arbovirus infections with epidemic Potential: A systematic review
Novel and repurposed antiviral molecules for arbovirus infections with epidemic Potential: A systematic review Open
View article: Effectiveness and predictors of treatment discontinuation of long-acting cabotegravir/rilpivirine in virologically suppressed people with HIV: real-life data from the Icona Cohort
Effectiveness and predictors of treatment discontinuation of long-acting cabotegravir/rilpivirine in virologically suppressed people with HIV: real-life data from the Icona Cohort Open
Background Phase 3 studies have shown long-acting (LA) cabotegravir/rilpivirine to be effective and tolerable as maintenance therapy in people with HIV (PWH). However, real-life data on their effectiveness are limited. Methods All PWH enro…
View article: Selected comorbidities and the probability of ART switch in PWH with undetectable HIV-RNA: a retrospective analysis in Italy
Selected comorbidities and the probability of ART switch in PWH with undetectable HIV-RNA: a retrospective analysis in Italy Open
Objectives To estimate the incidence of comorbidities in persons with HIV (PWH) with a stable viral load (VL) of ≤50 copies/mL and evaluate the likelihood of treatment switch (TS) according to the new development of dyslipidaemia (DP), kid…
View article: Penile vascular status in young men living with HIV experiencing erectile dysfunction: A comparative cross‐sectional pilot study
Penile vascular status in young men living with HIV experiencing erectile dysfunction: A comparative cross‐sectional pilot study Open
Background Erectile dysfunction in people living with HIV is a multifactorial disease, but the role of penile vascular status assessed by dynamic penile color Doppler echography is underexplored. Objectives This study assessed penile vascu…
View article: Immune Escape and Drug Resistance Mutations in Patients with Hepatitis B Virus Infection: Clinical and Epidemiological Implications
Immune Escape and Drug Resistance Mutations in Patients with Hepatitis B Virus Infection: Clinical and Epidemiological Implications Open
Hepatitis B virus (HBV) genetic variability, shaped by high mutation rates and selective pressures, complicates its management and increases the emergence of drug-resistant and immune-escape variants. This study aims to analyze immune esca…
View article: Role of low-frequency integrase strand transfer inhibitor resistance mutations on virological outcomes in antiretroviral therapy-naïve individuals initiating second-generation integrase inhibitors
Role of low-frequency integrase strand transfer inhibitor resistance mutations on virological outcomes in antiretroviral therapy-naïve individuals initiating second-generation integrase inhibitors Open
View article: P07. Risk of viral blip and virological failure with DTG-3TC versus B-F-TAF in a real-life setting
P07. Risk of viral blip and virological failure with DTG-3TC versus B-F-TAF in a real-life setting Open
Background While the long-term efficacy and durability of dolutegravir-lamivudine (DTG-3TC) are well established, the risk of viral blip (VB) and virological failure (VF) in real-life settings remains to be fully assessed. This study compa…
View article: Effects of Climate Change on the Immune System: A Narrative Review
Effects of Climate Change on the Immune System: A Narrative Review Open
Background and Aims Human activities have greatly influenced global temperatures, leading to climate change and global warming. This narrative review aims to explore the relationship between climate change and the immune system, focusing o…
View article: Understanding HIV-Exposed Uninfected Children: A Narrative Review
Understanding HIV-Exposed Uninfected Children: A Narrative Review Open
The widespread implementation of antiretroviral therapy has significantly reduced HIV-related mortality and mother-to-child transmission. Despite being HIV-uninfected, HIV-exposed children (HEU) seem to face heightened risks of immune dysf…
View article: Mpox in pregnancy: Unraveling the maternal-fetal risks of a re-emerging disease, a narrative review
Mpox in pregnancy: Unraveling the maternal-fetal risks of a re-emerging disease, a narrative review Open
Mpox has re-emerged, particularly with the spread of Clade Ib in 2024 and recent outbreaks have raised concerns about its impact on pregnant women. Limited data suggest increased risks of adverse outcomes such as stillbirths and miscarriag…
View article: Weight gain, obesity, and the impact of lifestyle factors among people living with HIV: A systematic review
Weight gain, obesity, and the impact of lifestyle factors among people living with HIV: A systematic review Open
Summary HIV remains a significant health concern, but the advent of antiretroviral therapy (ART) has transformed it into a manageable chronic condition. However, weight gain and obesity pose a substantial challenge for people living with H…
View article: Introduction of Vector-Borne Infections in Europe: Emerging and Re-Emerging Viral Pathogens with Potential Impact on One Health
Introduction of Vector-Borne Infections in Europe: Emerging and Re-Emerging Viral Pathogens with Potential Impact on One Health Open
The rise and resurgence of vector-borne diseases (VBDs) in Europe pose an expanding public health challenge, exacerbated by climate change, globalization, and ecological disruptions. Both arthropod-borne viruses (arboviruses) transmitted b…
View article: Effectiveness, safety, and patient-reported outcomes of bictegravir/emtricitabine/tenofovir alafenamide in routine clinical care in Italy: 12-Month results from the BICSTaR cohort
Effectiveness, safety, and patient-reported outcomes of bictegravir/emtricitabine/tenofovir alafenamide in routine clinical care in Italy: 12-Month results from the BICSTaR cohort Open
Background BICSTaR is a multi-national, observational cohort evaluating the effectiveness, safety, and patient-reported outcomes (PROs) in treatment-naïve (TN) and -experienced (TE) people with HIV-1 receiving bictegravir/emtricitabine/ten…
View article: Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels
Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels Open
Introduction T cells are involved in the early identification and clearance of viral infections and also support the development of antibodies by B cells. This central role for T cells makes them a desirable target for assessing the immune…
View article: Editorial: Antiviral drugs: neurotoxicity and neurodevelopmental effects
Editorial: Antiviral drugs: neurotoxicity and neurodevelopmental effects Open
View article: Kinetics of hepatitis B virus replication in anti-HBc positive/HBsAg-negative people with HIV switching to tenofovir sparing therapy
Kinetics of hepatitis B virus replication in anti-HBc positive/HBsAg-negative people with HIV switching to tenofovir sparing therapy Open
This study underlines the importance to regularly monitor anti-HBc-positive/HBsAg-negative PWH undergoing TDF/TAF-sparing regimen and the role of highly-sensitive HBV markers in optimizing their management.
View article: Effect of Oral Bisphosphonates on Vertebral Fractures in Males Living with HIV: A Seven Year Study
Effect of Oral Bisphosphonates on Vertebral Fractures in Males Living with HIV: A Seven Year Study Open
Background: Osteoporosis and vertebral fractures (VFs) are frequently observed in males living with HIV (MLWH). While bisphosphonates seem effective on bone mineral density (BMD) in MLWH, data on VFs are lacking. In this real-life longitud…
View article: A Rare Case and Literature Review of Pyelo-Hepatic Abscess in an Immunocompetent Patient: When Effective Source Control and Targeted Antimicrobial Therapy Might Not Be Enough
A Rare Case and Literature Review of Pyelo-Hepatic Abscess in an Immunocompetent Patient: When Effective Source Control and Targeted Antimicrobial Therapy Might Not Be Enough Open
Pyelo-hepatic abscess is a rare complication of upper urinary tract infections (UTIs). We describe a case of polymicrobial pyelo-hepatic abscess in an immunocompetent patient. A 71-year-old male patient with a double-J stent for right uret…
View article: Protocol for the LIFEH project: a prospective observational study to explore lifestyle among people living with HIV experiencing weight gain, looking beyond antiretroviral therapy
Protocol for the LIFEH project: a prospective observational study to explore lifestyle among people living with HIV experiencing weight gain, looking beyond antiretroviral therapy Open
Introduction Weight gain, together with the onset of overweight and obesity, is a relevant emerging health issue among people living with HIV (PLWH). A large body of literature recognises this issue as a part of the secondary effects of so…
View article: Sexual dysfunction in women living with HIV: an updated narrative review
Sexual dysfunction in women living with HIV: an updated narrative review Open
Introduction Female sexual dysfunction is a significant concern for many women worldwide, with chronic health conditions such as HIV infection contributing to its prevalence. However, there is a paucity of studies focusing this subject in …
View article: Long-acting injectable antiretrovirals for HIV treatment in the ICONA cohort: physicians’ and nurses’ points of view
Long-acting injectable antiretrovirals for HIV treatment in the ICONA cohort: physicians’ and nurses’ points of view Open
Background Implementation level of long-acting injectable agents cabotegravir/rilpivirine (LAI CAB/RPV) for human immunodeficiency virus (HIV) treatment in Italy is still not known. The aim of this study is to identify the status of implem…
View article: Monoclonal antibodies against SARS-CoV-2 to prevent COVID-19 worsening in a large multicenter cohort
Monoclonal antibodies against SARS-CoV-2 to prevent COVID-19 worsening in a large multicenter cohort Open
MAbs real-world data over a 2-year changing pandemic landscape showed the feasibility of the intervention, although the hospitalization rate was not negligible. Immunosuppressed subjects remain more at risk of clinical worsening.
View article: Long-term symptoms after SARS-CoV-2 infection in a cohort of people living with HIV
Long-term symptoms after SARS-CoV-2 infection in a cohort of people living with HIV Open
Background Our Hospital in Northern Italy assists 3817 people living with HIV (PLWH) and has faced the impact of COVID-19. Little is known about the impact of HIV infection on the risk of post-COVID-19 conditions (PCCs) onset. We aim to as…
View article: Dolutegravir and Folic Acid Interaction during Neural System Development in Zebrafish Embryos
Dolutegravir and Folic Acid Interaction during Neural System Development in Zebrafish Embryos Open
Dolutegravir (DTG) is one of the most prescribed antiretroviral drugs for treating people with HIV infection, including women of child-bearing potential or pregnant. Nonetheless, neuropsychiatric symptoms are frequently reported. Early rep…
View article: Immunogenicity and safety of live attenuated and recombinant/inactivated varicella zoster vaccines in people living with HIV: A systematic review
Immunogenicity and safety of live attenuated and recombinant/inactivated varicella zoster vaccines in people living with HIV: A systematic review Open
Few papers focus their attention on VZV vaccination effectiveness among people living with HIV (PLWH). Flanking the live attenuated vaccine (VZL) available, a newly recombinant vaccine (RZV) was recently introduced and approved for HZ prev…
View article: The Impact of Immune System Aging on Infectious Diseases
The Impact of Immune System Aging on Infectious Diseases Open
Immune system aging is becoming a field of increasing public health interest because of prolonged life expectancy, which is not paralleled by an increase in health expectancy. As age progresses, innate and adaptive immune systems undergo c…
View article: Long-term outcomes of bictegravir/emtricitabine/tenofovir alafenamide as first-line therapy and as switch strategy in virologically suppressed persons with HIV: data from the ICONA cohort
Long-term outcomes of bictegravir/emtricitabine/tenofovir alafenamide as first-line therapy and as switch strategy in virologically suppressed persons with HIV: data from the ICONA cohort Open
Objectives To assess the effectiveness of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) among people poorly represented in clinical trials and potentially at higher risk of suboptimal response to ART. Methods Observational …