Eugenii A. Rabiner
YOU?
Author Swipe
View article: An in vivo PET/CT investigation of mitochondrial complex 1, sigma 1, and synaptic vesicle 2 A in patients with amyotrophic lateral sclerosis
An in vivo PET/CT investigation of mitochondrial complex 1, sigma 1, and synaptic vesicle 2 A in patients with amyotrophic lateral sclerosis Open
Our findings reveal loss of MC1 and S1R in ALS, suggesting mitochondrial dysfunction associated with disease progression. This work provides initial insights of mitochondrial and receptor pathology in ALS, potentially guiding future biomar…
View article: The trace amine-associated receptor 1 regulates presynaptic dopamine function: evidence from preclinical studies and a phase 1b trial in patients with schizophrenia
The trace amine-associated receptor 1 regulates presynaptic dopamine function: evidence from preclinical studies and a phase 1b trial in patients with schizophrenia Open
TAAR1 regulates dopamine synthesis and release. Adjunctive ulotaront reduces presynaptic dopamine function and psychotic symptoms in schizophrenia. These findings support TAAR1 as a promising target for treating antipsychotic non-responsiv…
View article: Corticolimbic network perturbations in early psychosis: an arterial spin labelling and [11C]Ro15-4513 positron emission tomography study
Corticolimbic network perturbations in early psychosis: an arterial spin labelling and [11C]Ro15-4513 positron emission tomography study Open
Background Hippocampal hyperactivity in early psychosis may result from excitation-inhibition imbalance within corticolimbic regions. Preclinical evidence suggests that positive allosteric modulation of hippocampal inhibitory γ-aminobutyri…
View article: GABAA receptor availability in clinical high-risk and first-episode psychosis: a [11C]Ro15-4513 positron emission tomography study
GABAA receptor availability in clinical high-risk and first-episode psychosis: a [11C]Ro15-4513 positron emission tomography study Open
Disrupted gamma-aminobutyric acid (GABA) neurotransmission may contribute to the pathophysiology of schizophrenia. Reductions in hippocampal GABAergic neurons have been found in schizophrenia, and increased hippocampal perfusion has been d…
View article: Evaluation of Mitochondrial Complex 1 Density with [<sup>18</sup>F]BCPP-EF in a Murine Model and Individuals with Friedreich Ataxia
Evaluation of Mitochondrial Complex 1 Density with [<sup>18</sup>F]BCPP-EF in a Murine Model and Individuals with Friedreich Ataxia Open
Friedreich ataxia is caused by mutations in the frataxin gene, leading to neurodegeneration and premature death from cardiac dysfunction. Loss of frataxin impacts mitochondrial complex 1 (MC1) activity, suggesting MC1 may be a potential bi…
View article: Detecting neuroplastic effects induced by ketamine in healthy human subjects: a multimodal approach
Detecting neuroplastic effects induced by ketamine in healthy human subjects: a multimodal approach Open
We investigated ketamine’s neuroplastic effects in healthy human subjects using integrated Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) measures before and 1-8 days after a single psychedelic dose of ketamine (1 mg/k…
View article: The relationship between cortical synaptic terminal density marker SV2A and glutamate early in the course of schizophrenia: a multimodal PET and MRS imaging study
The relationship between cortical synaptic terminal density marker SV2A and glutamate early in the course of schizophrenia: a multimodal PET and MRS imaging study Open
View article: GABA<sub>A</sub>receptor availability in clinical high-risk and first-episode psychosis: a [<sup>11</sup>C]Ro15-4513 positron emission tomography study
GABA<sub>A</sub>receptor availability in clinical high-risk and first-episode psychosis: a [<sup>11</sup>C]Ro15-4513 positron emission tomography study Open
Disrupted gamma-aminobutyric acid (GABA) neurotransmission may contribute to the pathophysiology of schizophrenia. Reductions in hippocampal GABAergic neurons have been found in schizophrenia, and increased hippocampal perfusion has been d…
View article: Mitochondria and Cognition: An [18F]BCPP-EF Positron Emission Tomography Study of Mitochondrial Complex I Levels and Brain Activation During Task Switching
Mitochondria and Cognition: An [18F]BCPP-EF Positron Emission Tomography Study of Mitochondrial Complex I Levels and Brain Activation During Task Switching Open
Higher mitochondrial complex I levels may underlie an individual's ability to exhibit a stronger BOLD response during task switching and are associated with better task-switching performance. This provides the first evidence linking the BO…
View article: Correction: Quantifying VMAT2 target occupancy at effective valbenazine doses and comparing to a novel VMAT2 inhibitor: a translational PET study
Correction: Quantifying VMAT2 target occupancy at effective valbenazine doses and comparing to a novel VMAT2 inhibitor: a translational PET study Open
View article: Quantifying VMAT2 target occupancy at effective valbenazine doses and comparing to a novel VMAT2 inhibitor: a translational PET study
Quantifying VMAT2 target occupancy at effective valbenazine doses and comparing to a novel VMAT2 inhibitor: a translational PET study Open
View article: The relationship between synaptic vesicle glycoprotein 2A and glutamate is altered early in the course of schizophrenia
The relationship between synaptic vesicle glycoprotein 2A and glutamate is altered early in the course of schizophrenia Open
View article: Emotion processing in schizophrenia and its relation to μ-opioid receptor availability
Emotion processing in schizophrenia and its relation to μ-opioid receptor availability Open
We found no evidence of impaired emotion-related brain activation in the hedonic network in schizophrenia patients with moderate negative symptoms compared to healthy individuals, and baseline MOR availability did not predict the neural re…
View article: Working memory processes and the histamine-3 receptor in schizophrenia: a [11C]MK-8278 PET-fMRI study
Working memory processes and the histamine-3 receptor in schizophrenia: a [11C]MK-8278 PET-fMRI study Open
Rationale Working memory impairment is a prominent feature of schizophrenia which predicts clinical and functional outcomes. Preclinical data suggest histamine-3 receptor (H3R) expression in cortical pyramidal neurons may have a role in wo…
View article: Preclinical <i>in vitro</i> and <i>in vivo</i> evaluation of [ <sup>11</sup> C]ORM-13070 as PET ligand for alpha-2C adrenergic receptor occupancy using PET imaging in non-human primates
Preclinical <i>in vitro</i> and <i>in vivo</i> evaluation of [ <sup>11</sup> C]ORM-13070 as PET ligand for alpha-2C adrenergic receptor occupancy using PET imaging in non-human primates Open
This paper describes the preclinical validation of the radioligand [ 11 C]ORM-13070 and its tritiated analog for addressing selectivity and occupancy of the selective alpha-2C adrenergic receptor (α 2C R) antagonist BAY 292 in the cynomolg…
View article: Imaging the 5-HT<sub>2C</sub> receptor with PET: Evaluation of 5-HT<sub>2C</sub> and 5-HT<sub>2A</sub> affinity of pimavanserin in the primate brain
Imaging the 5-HT<sub>2C</sub> receptor with PET: Evaluation of 5-HT<sub>2C</sub> and 5-HT<sub>2A</sub> affinity of pimavanserin in the primate brain Open
Two complimentary techniques were used to estimate occupancy of pimavanserin (a selective 5-HT 2A/2C inverse agonist) to 5-HT 2A and 5-HT 2C receptors in non-human primate brains. One employed the 5-HT 2A/2C selective radioligand [ 11 C]CI…
View article: Mesostriatal Dopaminergic Circuit Dysfunction in Schizophrenia: A Multimodal Neuromelanin-Sensitive Magnetic Resonance Imaging and [18F]-DOPA Positron Emission Tomography Study
Mesostriatal Dopaminergic Circuit Dysfunction in Schizophrenia: A Multimodal Neuromelanin-Sensitive Magnetic Resonance Imaging and [18F]-DOPA Positron Emission Tomography Study Open
View article: Women and men with distressing low sexual desire exhibit sexually dimorphic brain processing
Women and men with distressing low sexual desire exhibit sexually dimorphic brain processing Open
View article: Mitochondrial complex I density is associated with IQ and cognition in cognitively healthy adults: an in vivo [18F]BCPP-EF PET study
Mitochondrial complex I density is associated with IQ and cognition in cognitively healthy adults: an in vivo [18F]BCPP-EF PET study Open
View article: Histamine-3 Receptor Availability and Glutamate Levels in the Brain: A PET-1H-MRS Study of Patients With Schizophrenia and Healthy Controls
Histamine-3 Receptor Availability and Glutamate Levels in the Brain: A PET-1H-MRS Study of Patients With Schizophrenia and Healthy Controls Open
Background The histamine-3 receptor (H3R) may have a role in cognitive processes through its action as a presynaptic heteroreceptor inhibiting the release of glutamate in the brain. To explore this, we examined anterior cingulate cortex (A…
View article: Pharmacokinetics and brain sigma 1 (σ1) receptor occupancy of MR309, a selective σ1 receptor antagonist
Pharmacokinetics and brain sigma 1 (σ1) receptor occupancy of MR309, a selective σ1 receptor antagonist Open
Background and purpose: Preclinical studies of MR309, a selective sigma1 receptor (σ1R) antagonist, support a potential role in treating neuropathic pain. We report two studies that provide insight into the pharmacokinetics (PK) and brain …
View article: The relationship between SV2A levels, neural activity, and cognitive function in healthy humans: A [11C]UCB-J PET and fMRI study
The relationship between SV2A levels, neural activity, and cognitive function in healthy humans: A [11C]UCB-J PET and fMRI study Open
Synaptic terminal density is thought to influence cognitive function and neural activity, yet its role in cognition has not been explored in healthy humans. We examined these relationships using [11C]UCB-J positron emission tomography (PET…
View article: Neuroimaging and the Investigation of Drug-Drug Interactions Involving Psychedelics
Neuroimaging and the Investigation of Drug-Drug Interactions Involving Psychedelics Open
Psychedelic therapies are an emerging class of treatments in psychiatry with great potential, however relatively little is known about their interactions with other commonly used psychiatric medications. As psychedelic therapies become mor…
View article: Estimation of target occupancy in repeated dosing design studies using positron emission tomography: Biases due to target upregulation
Estimation of target occupancy in repeated dosing design studies using positron emission tomography: Biases due to target upregulation Open
Positron emission tomography (PET) has become indispensable in the quantification of target engagement by brain targeting medications. The relationship between the drug plasma concentration (or drug dose administered) and target occupancy …
View article: Neuroimaging in psychedelic drug development: past, present, and future
Neuroimaging in psychedelic drug development: past, present, and future Open
Psychedelic therapy (PT) is an emerging paradigm with great transdiagnostic potential for treating psychiatric disorders, including depression, addiction, post-traumatic stress disorder, and potentially others. ‘Classic’ serotonergic psych…
View article: The histamine system and cognitive function: An in vivo H3 receptor PET imaging study in healthy volunteers and patients with schizophrenia
The histamine system and cognitive function: An in vivo H3 receptor PET imaging study in healthy volunteers and patients with schizophrenia Open
Background: The histamine-3 receptor (H3R) is an auto- and heteroreceptor that inhibits the release of histamine and other neurotransmitters. Post-mortem evidence has found altered H3R expression in patients with psychotic disorders, which…
View article: Synaptic Terminal Density Early in the Course of Schizophrenia: An In Vivo UCB-J Positron Emission Tomographic Imaging Study of SV2A
Synaptic Terminal Density Early in the Course of Schizophrenia: An In Vivo UCB-J Positron Emission Tomographic Imaging Study of SV2A Open
View article: Translocator protein PET imaging in temporal lobe epilepsy: A reliable test-retest study using asymmetry index
Translocator protein PET imaging in temporal lobe epilepsy: A reliable test-retest study using asymmetry index Open
Objective Translocator protein (TSPO) targeting positron emission tomography (PET) imaging radioligands have potential utility in epilepsy to assess the efficacy of novel therapeutics for targeting neuroinflammation. However, previous stud…
View article: Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder
Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder Open
Importance The human physiological sexual response is crucial for reward, satisfaction, and reproduction. Disruption of the associated neurophysiological pathways predisposes to low sexual desire; the most prevalent psychological form is h…
View article: Reward processing in schizophrenia and its relation to Mu opioid receptor availability and negative symptoms: A [11C]-carfentanil PET and fMRI study
Reward processing in schizophrenia and its relation to Mu opioid receptor availability and negative symptoms: A [11C]-carfentanil PET and fMRI study Open
Our data suggest reduced MOR availability in schizophrenia might not underlie striatal hypoactivation during reward anticipation in patients with established illness. Therefore, other mechanisms, such as dopamine dysfunction, warrant furth…