Eugenio Ragazzi
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View article: Postural test to differentiate primary aldosteronism from low-renin hypertension: a retrospective single-center study
Postural test to differentiate primary aldosteronism from low-renin hypertension: a retrospective single-center study Open
Background The diagnostic accuracy of screening and confirmatory tests to differentiate primary aldosteronism (PA) among patients with low-renin hypertension (HTN) is suboptimal. We aimed to assess the role of the postural stimulation test…
View article: Beyond Green: The Therapeutic Potential of Chlorophyll and Its Derivatives in Diabetes Control
Beyond Green: The Therapeutic Potential of Chlorophyll and Its Derivatives in Diabetes Control Open
Chlorophyll, the green pigment essential for photosynthesis, abundantly found in green vegetables and algae, has attracted growing scientific interest for its potential therapeutic effects, particularly in diabetes management. Recent resea…
View article: In silico analysis of bioactive compounds from ethanolic amber extract targeting BACE1: Potential implications for glucose metabolism
In silico analysis of bioactive compounds from ethanolic amber extract targeting BACE1: Potential implications for glucose metabolism Open
Ethanolic amber extract contains a mixture of terpenoids and other compounds with potential biological properties. This study aimed to explore in silico the interaction of selected constituents of amber extract on β-site amyloid precursor …
View article: Postural test to differentiate primary aldosteronism from low-renin hypertension
Postural test to differentiate primary aldosteronism from low-renin hypertension Open
Background The diagnostic accuracy of screening and confirmatory tests to differentiate primary aldosteronism (PA) among patients with low-renin hypertension (HTN) is suboptimal. We aimed to assess the role of postural stimulation test (PS…
View article: Artificial Intelligence Algorithm to Screen for Diabetic Neuropathy: A Pilot Study
Artificial Intelligence Algorithm to Screen for Diabetic Neuropathy: A Pilot Study Open
Background/Objectives: Patients with type 2 diabetes (T2D) are at risk of developing multiple complications, and diabetic polyneuropathy (DPN) is by far the most common. The purpose of the present study was to assess the ability of a new a…
View article: Endometriotic Follicular Fluid Affects Granulosa Cells’ Morphology and Increases Duplication Rate and Connexin-43 Expression
Endometriotic Follicular Fluid Affects Granulosa Cells’ Morphology and Increases Duplication Rate and Connexin-43 Expression Open
Endometriosis is a complicated condition characterized by inflammation, low oocyte quality, and decreased uterus receptivity, associated with fertility issues. This study aims to better understand the reduced pregnancy outcome in endometri…
View article: A Combination of 5-(3′,4′-Dihydroxyphenyl)-γ-Valerolactone and Curcumin Synergistically Reduces Neuroinflammation in Cortical Microglia by Targeting the NLRP3 Inflammasome and the NOX2/Nrf2 Signaling Pathway
A Combination of 5-(3′,4′-Dihydroxyphenyl)-γ-Valerolactone and Curcumin Synergistically Reduces Neuroinflammation in Cortical Microglia by Targeting the NLRP3 Inflammasome and the NOX2/Nrf2 Signaling Pathway Open
Background/Objectives: 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone (γ-VL), recently identified as a predominant microbial metabolite derived from proanthocyanidins, offers benefits such as reducing inflammation, oxidative stress, and support…
View article: Circulating Factors as Potential Biomarkers of Cardiovascular Damage Progression Associated with Type 2 Diabetes
Circulating Factors as Potential Biomarkers of Cardiovascular Damage Progression Associated with Type 2 Diabetes Open
Background: Diabetes, particularly type 2 diabetes (T2D), is linked with an increased risk of developing coronary heart disease (CHD). The present study aimed to evaluate potential circulating biomarkers of CHD by adopting a targeted prote…
View article: Immature Surfactant Protein Type B and Surfactant Protein Type D Correlate with Coronary Heart Disease in Patients with Type 2 Diabetes
Immature Surfactant Protein Type B and Surfactant Protein Type D Correlate with Coronary Heart Disease in Patients with Type 2 Diabetes Open
Background: Different specific surfactant proteins (SPs) have been associated with various pathological conditions, not only of the respiratory system, but also more recently with cardiovascular diseases, such as heart failure. The aim of …
View article: Selective ILM Staining and Safety of Two Vital Dyes During a Human-Like Pars Plana Vitrectomy <i>Ex Vivo</i> in Porcine Eyes
Selective ILM Staining and Safety of Two Vital Dyes During a Human-Like Pars Plana Vitrectomy <i>Ex Vivo</i> in Porcine Eyes Open
An ideal dye for intraocular use should effectively stain the target tissue while being easy to apply and remove. Additionally, it should not have any adverse effects resulting from prolonged contact with the retinal tissue. Recently, conc…
View article: Assessment of performance and safety of Corneal Chamber hypothermic storage medium and PSS-L corneal rinsing solution in human and porcine corneas
Assessment of performance and safety of Corneal Chamber hypothermic storage medium and PSS-L corneal rinsing solution in human and porcine corneas Open
Purpose To prove the safety and performance of the hypothermic corneal storage medium "Corneal Chamber" and the rinsing solution "PSS-L" in support of the new Conformité Européenne (CE) certification process in accordance with the Medical …
View article: Dysfunction in endocannabinoids, palmitoylethanolamide, and degradation of tryptophan into kynurenine in individuals with depressive symptoms
Dysfunction in endocannabinoids, palmitoylethanolamide, and degradation of tryptophan into kynurenine in individuals with depressive symptoms Open
Background The endocannabinoid (eCB) system and the serotonin (5-HT) are both implicated in the severity of the depression. 5-HT is synthesized from the amino acid tryptophan (Trp), which is also a precursor for kynurenine (Kyn) whose prod…
View article: Is eGFR Slope a Novel Predictor of Chronic Complications of Type 2 Diabetes Mellitus? A Systematic Review and Meta‐Analysis
Is eGFR Slope a Novel Predictor of Chronic Complications of Type 2 Diabetes Mellitus? A Systematic Review and Meta‐Analysis Open
Background . Diabetic kidney disease affects approximately 40% of patients with type 2 diabetes mellitus (T2DM) and is associated with an increased risk of end‐stage kidney disease (ESKD) and cardiovascular (CV) events, as well as increase…
View article: Lipid profile in women of different ethnicity with gestational diabetes: Relationship with fetal growth
Lipid profile in women of different ethnicity with gestational diabetes: Relationship with fetal growth Open
Aims/Introduction Pregnancy complicated by gestational diabetes mellitus (GDM) is characterized by excessive insulin resistance that impairs the metabolism of glucose and lipids. the aim of the study was to examine lipid profiles during pr…
View article: Anti-diabetic combination therapy with pioglitazone or glimepiride added to metformin on the AGE-RAGE axis: a randomized prospective study
Anti-diabetic combination therapy with pioglitazone or glimepiride added to metformin on the AGE-RAGE axis: a randomized prospective study Open
Introduction The ratio between advanced glycation end products (AGEs) and soluble form of receptor (s-RAGE) has been proposed as a risk marker for renal and cardiovascular diseases. The aim of this study was to evaluate in the diabetes con…
View article: P12-A107 Porcine cornea ex vivo model as an alternative to human donor tissues for investigating new preservation conditions
P12-A107 Porcine cornea ex vivo model as an alternative to human donor tissues for investigating new preservation conditions Open
The presented porcine cornea model represents a reliable and alternative model to human donor tissues for preliminary investigations and can be used for testing new media, substances, drugs, or preservation conditions and their impact on c…
View article: Association of COVID-19 outcomes with diabetes in the Veneto region (north-east italy): Epidemiological insights for the endemic phase?
Association of COVID-19 outcomes with diabetes in the Veneto region (north-east italy): Epidemiological insights for the endemic phase? Open
Considering the potential for COVID-19 to become endemic, special care should be taken in managing older diabetic patients' treatments.
View article: Luteolin and Vernodalol as Bioactive Compounds of Leaf and Root Vernonia amygdalina Extracts: Effects on α-Glucosidase, Glycation, ROS, Cell Viability, and In Silico ADMET Parameters
Luteolin and Vernodalol as Bioactive Compounds of Leaf and Root Vernonia amygdalina Extracts: Effects on α-Glucosidase, Glycation, ROS, Cell Viability, and In Silico ADMET Parameters Open
The aqueous decoctions of Vernonia amygdalina (VA) leaves and roots are widely used in traditional African medicine as an antidiabetic remedy. The amount of luteolin and vernodalol in leaf and root extracts was detected, and their role was…
View article: Maintenance of intestinal epithelial barrier integrity by a combination of probiotics, herbal extract, and vitamins
Maintenance of intestinal epithelial barrier integrity by a combination of probiotics, herbal extract, and vitamins Open
This work, in line with previous observations, supports a protective role of Lactobacillus reuteri DSM 25175, Lactobacillus acidophilus DSM 24936 and the other components in the maintenance of a healthy gut, holding up the use of this comb…
View article: Porcine Cornea Storage Ex Vivo Model as an Alternative to Human Donor Tissues for Investigations of Endothelial Layer Preservation
Porcine Cornea Storage Ex Vivo Model as an Alternative to Human Donor Tissues for Investigations of Endothelial Layer Preservation Open
The porcine cornea storage model can be used to investigate the efficacy and safety of new media, substances, or storage conditions. Furthermore, the method developed to assess the percentage of endothelial mortality is tissue conservative…
View article: Contribution of Mitochondrial Activity to Doxorubicin-Resistance in Osteosarcoma Cells
Contribution of Mitochondrial Activity to Doxorubicin-Resistance in Osteosarcoma Cells Open
Osteosarcoma is considered the most common bone tumor affecting children and young adults. The standard of care is chemotherapy; however, the onset of drug resistance still jeopardizes osteosarcoma patients, thus making it necessary to con…
View article: Telemedicine and its acceptance by patients with type 2 diabetes mellitus at a single care center during the COVID-19 emergency: A cross-sectional observational study
Telemedicine and its acceptance by patients with type 2 diabetes mellitus at a single care center during the COVID-19 emergency: A cross-sectional observational study Open
Introduction When Italy was placed under lockdown to contain the COVID-19 pandemic from 9 March to 18 May 2020, alternative approaches to delivering care—such as telemedicine—were promoted for patients with chronic diseases like diabetes m…
View article: Supplementary material for manuscript - IJMS - by Ragazzi et al.
Supplementary material for manuscript - IJMS - by Ragazzi et al. Open
Supplementary material for manuscript - IJMS - by Ragazzi et al. Figure S1. Dendrogram showing the distribution of Δ glyco-oxidation parameters among patients of the two treatment groups. Ward’s clustering method, values standardized by ea…
View article: Long-term HbA1c variability and macro-/micro-vascular complications in type 2 diabetes mellitus: a meta-analysis update
Long-term HbA1c variability and macro-/micro-vascular complications in type 2 diabetes mellitus: a meta-analysis update Open
Aims The aim of the present study was to evaluate, by means of a meta-analysis approach, whether new available data, appeared on qualified literature, can support the effectiveness of an association of HbA1c variability with the risk of ma…
View article: Comparison of Perfluorocarbon Liquids Cytotoxicity Tests: Direct Contact Versus the Test on Liquid Extracts
Comparison of Perfluorocarbon Liquids Cytotoxicity Tests: Direct Contact Versus the Test on Liquid Extracts Open
The purpose of this study is to compare the in vitro cytotoxicity tests according to the ISO 10993-5 (2009) standards using direct contact and the test on liquid extracts of compounds previously identified as possible toxic impurities in p…