Eui-Hwan Choi
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View article: Identification of YAP regulators through high-throughput screening and NanoBiT-based validation-drug repositioning for cancer therapy
Identification of YAP regulators through high-throughput screening and NanoBiT-based validation-drug repositioning for cancer therapy Open
Yes-associated protein (YAP), a key co-transcription factor of the Hippo pathway, is a promising drug target for cancer therapy due to its critical role in promoting cell proliferation, survival, and tumor progression when dysregulated. Wh…
View article: Targeting Mitochondrial Dysfunction and Reactive Oxygen Species for Neurodegenerative Disease Treatment
Targeting Mitochondrial Dysfunction and Reactive Oxygen Species for Neurodegenerative Disease Treatment Open
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative diseases, and they affect millions of people worldwide, particularly older individuals. Therefore, there is a clear need to develop novel drug targ…
View article: Synergistic combination of RAD51-SCR7 improves CRISPR-Cas9 genome editing efficiency by preventing R-loop accumulation
Synergistic combination of RAD51-SCR7 improves CRISPR-Cas9 genome editing efficiency by preventing R-loop accumulation Open
CRISPR-Cas9 has emerged as a powerful tool for genome editing. However, Cas9 genome editing faces challenges, including low efficiency and off-target effects. Here, we report that combined treatment with RAD51, a key factor in homologous r…
View article: RPA interacts with Rad52 to promote meiotic crossover and noncrossover recombination
RPA interacts with Rad52 to promote meiotic crossover and noncrossover recombination Open
Meiotic recombination is initiated by programmed double-strand breaks (DSBs). Studies in Saccharomyces cerevisiae have shown that, following rapid resection to generate 3′ single-stranded DNA (ssDNA) tails, one DSB end engages a homolog pa…
View article: TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target
TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target Open
Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and inhibits its antioxidant function and expression. However, re…
View article: α-Kleisin subunit of cohesin preserves the genome integrity of embryonic stem cells
α-Kleisin subunit of cohesin preserves the genome integrity of embryonic stem cells Open
Cohesin is a ring-shaped protein complex that comprises the SMC1, SMC3, and α-kleisin proteins, STAG1/2/3 subunits, and auxiliary factors. Cohesin participates in chromatin remodeling, chromosome segregation, DNA replication, and gene expr…
View article: Elevated expression of exogenous RAD51 enhances the CRISPR/Cas9-mediated genome editing efficiency
Elevated expression of exogenous RAD51 enhances the CRISPR/Cas9-mediated genome editing efficiency Open
Genome editing using CRISPR-associated technology is widely used to modify the genomes rapidly and efficiently on specific DNA double-strand breaks (DSBs) induced by Cas9 endonuclease. However, despite swift advance in Cas9 engineering, st…
View article: The Kleisin Subunits of Cohesin Are Involved in the Fate Determination of Embryonic Stem Cells
The Kleisin Subunits of Cohesin Are Involved in the Fate Determination of Embryonic Stem Cells Open
As a potential candidate to generate an everlasting cell source to treat various diseases, embryonic stem cells are regarded as a promising therapeutic tool in the regenerative medicine field. Cohesin, a multi-functional complex that contr…
View article: Meiosis-Specific Cohesin Complexes Display Distinct and Essential Roles in Mitotic ESC Chromosomes
Meiosis-Specific Cohesin Complexes Display Distinct and Essential Roles in Mitotic ESC Chromosomes Open
Cohesin is a chromosome-associated SMC kleisin complex that mediates sister chromatid cohesion, recombination, and most chromosomal processes during mitosis and meiosis. Through high-resolution 3D-structured illumination microscopy and fun…
View article: Combined Ectopic Expression of Homologous Recombination Factors Promotes Embryonic Stem Cell Differentiation
Combined Ectopic Expression of Homologous Recombination Factors Promotes Embryonic Stem Cell Differentiation Open
Homologous recombination (HR), which ensures accurate DNA replication and strand-break repair, is necessary to preserve embryonic stem cell (ESC) self-renewal. However, little is known about how HR factors modulate ESC differentiation and …
View article: The Homologous Recombination Machinery Orchestrates Post-replication DNA Repair During Self-renewal of Mouse Embryonic Stem Cells
The Homologous Recombination Machinery Orchestrates Post-replication DNA Repair During Self-renewal of Mouse Embryonic Stem Cells Open
Embryonic stem (ES) cells require homologous recombination (HR) to cope with genomic instability caused during self-renewal. Here, we report expression dynamics and localization of endogenous HR factors in DNA break repair of ES cells. In …