Eui Hyun Kim
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View article: Neoadjuvant Gamma Knife Surgery for Metastatic Brain Tumor: Clinical Use and Impact on Leptomeningeal Seeding
Neoadjuvant Gamma Knife Surgery for Metastatic Brain Tumor: Clinical Use and Impact on Leptomeningeal Seeding Open
Purpose This study aimed to compare leptomeningeal seeding (LMS) incidence, local failure rates, and survival outcomes between neoadjuvant and adjuvant gamma knife surgery (GKS) in patients with brain metastases. Methods We retrospectively…
View article: EPCO-19. PRECANCEROUS OPC-LIKE CELLS DRIVE GLIOBLASTOMA EVOLUTION AND SHAPE INTRATUMORAL HETEROGENEITY
EPCO-19. PRECANCEROUS OPC-LIKE CELLS DRIVE GLIOBLASTOMA EVOLUTION AND SHAPE INTRATUMORAL HETEROGENEITY Open
Glioblastoma (GBM) is the most aggressive primary brain tumor, characterized by profound intratumoral heterogeneity. Recent studies have identified neural stem cells (NSCs) in the subventricular zone (SVZ) as potential cells-of-origin harb…
View article: CNSC-08. A STUDY ON THE ROLE OF PLATELET-DERIVED GROWTH FACTOR RECEPTOR A GENE REGULATION IN SUBVENTRICULAR ZONE CELLS RELATED TO GLIOBLASTOMA DEVELOPMENT
CNSC-08. A STUDY ON THE ROLE OF PLATELET-DERIVED GROWTH FACTOR RECEPTOR A GENE REGULATION IN SUBVENTRICULAR ZONE CELLS RELATED TO GLIOBLASTOMA DEVELOPMENT Open
Glioblastoma (GBM) is an aggressive brain tumor known for frequent recurrence and treatment resistance. Recent studies suggest that neural stem cells (NSCs) in the subventricular zone (SVZ) may act as cells-of-origin for IDH-wildtype GBM. …
View article: PATH-71. Survival analysis of adult diffuse midline gliomas and the clinical significance of H3K27 alteration
PATH-71. Survival analysis of adult diffuse midline gliomas and the clinical significance of H3K27 alteration Open
OBJECTIVE Although pediatric midline-located gliomas (MGs) with H3K27 alteration have been widely known to have a poor prognosis, few researchers have assessed adult MGs with H3K27 alteration. We aimed to determine the effect of H3K27 alte…
View article: Efficacy and Safety of High-Dose Pioglitazone as Add-on Therapy in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Dapagliflozin and Metformin: Double-Blind, Randomized, Placebo-Controlled Trial
Efficacy and Safety of High-Dose Pioglitazone as Add-on Therapy in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Dapagliflozin and Metformin: Double-Blind, Randomized, Placebo-Controlled Trial Open
Addition of pioglitazone 30 mg/day to T2DM patients who did not reach the target HbA1c (≤7%) with treatment of dapagliflozin 10 mg/day and metformin over 1,000 mg/day showed effective glucose lowering efficacy without significant hypoglyce…
View article: The new Bruton’s tyrosine kinase inhibitors SPA8007 and SPA8009 reduce stemness and invasiveness of patient-derived glioblastoma tumorspheres
The new Bruton’s tyrosine kinase inhibitors SPA8007 and SPA8009 reduce stemness and invasiveness of patient-derived glioblastoma tumorspheres Open
Glioblastoma (GBM), the most prevalent primary brain tumor, remains incurable due to the presence of cancer stem cells (CSCs), which can be isolated as tumorspheres (TSs) that exhibit classical characteristics of CSCs, including stemness a…
View article: MON-017 Single-cell Transcriptomic Profiling of Somatotroph Tumors Reveals Subtype-Specific Cellular and Molecular Characteristics
MON-017 Single-cell Transcriptomic Profiling of Somatotroph Tumors Reveals Subtype-Specific Cellular and Molecular Characteristics Open
Disclosure: E. Kim: None. H. Oh: None. C. Ku: None. While single-cell profiling has been extensively explored in various tumor types, pituitary adenomas, particularly somatotroph tumors (ST), remain understudied. These growth hormone-secre…
View article: Data from Precancerous Cells Initiate Glioblastoma Evolution and Contribute to Intratumoral Heterogeneity
Data from Precancerous Cells Initiate Glioblastoma Evolution and Contribute to Intratumoral Heterogeneity Open
Neural stem cells in the subventricular zone are identified as cells of origin harboring driver mutations in glioblastoma (GBM), which is the most devastating brain tumor with highly heterogeneous nature. However, the sequential transforma…
View article: Supplementary Figures S1-S15 from Precancerous Cells Initiate Glioblastoma Evolution and Contribute to Intratumoral Heterogeneity
Supplementary Figures S1-S15 from Precancerous Cells Initiate Glioblastoma Evolution and Contribute to Intratumoral Heterogeneity Open
Supplementary Figure S1. Enrichment of mutation-harboring cells during GBM evolution in the spontaneous GBM mouse model. Supplementary Figure S2. The quality control and pre-processing of single-cell RNA-seq data. Supplementary Figure S3. …
View article: Author Correction: A lignan from Alnus japonica inhibits glioblastoma tumorspheres by suppression of FOXM1
Author Correction: A lignan from Alnus japonica inhibits glioblastoma tumorspheres by suppression of FOXM1 Open
View article: N-phenylmaleimide induces bioenergetic switch and suppresses tumor growth in glioblastoma tumorspheres by inhibiting SLC25A11
N-phenylmaleimide induces bioenergetic switch and suppresses tumor growth in glioblastoma tumorspheres by inhibiting SLC25A11 Open
View article: 68Ga-DOTATOC PET/CT in the Localization of Pituitary Tumors in Cushing’s Disease
68Ga-DOTATOC PET/CT in the Localization of Pituitary Tumors in Cushing’s Disease Open
Background: This study aimed to determine the value of 68Ga-DOTATOC positron emission tomography/computed tomography (PET/CT) in localizing adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas.Methods: In this retrospective coho…
View article: Design optimisation of kirigami-based auxetic metamaterials with multistability and shape-morphing capability
Design optimisation of kirigami-based auxetic metamaterials with multistability and shape-morphing capability Open
This study presents the development of kirigami-based auxetic metamaterials with multistability and shape-morphing capabilities through a design optimisation framework leveraging machine learning technology. The framework employs surrogate…
View article: Resolution of Hyperprolactinemia Caused by Pituitary Stalk Compression After Transsphenoidal Surgery for Pituitary Tumors
Resolution of Hyperprolactinemia Caused by Pituitary Stalk Compression After Transsphenoidal Surgery for Pituitary Tumors Open
The postoperative resolution of hyperprolactinemia caused by stalk compression was possible in 90% within a year. The decline in serum prolactin levels typically began within the first 72 hours after surgery, indicating that the hormonal r…
View article: Enhancing Brain Metastases Detection and Segmentation in Black-Blood MRI Using Deep Learning and Segment Anything Model (SAM)
Enhancing Brain Metastases Detection and Segmentation in Black-Blood MRI Using Deep Learning and Segment Anything Model (SAM) Open
The modifications to standard U-Net notably improves the detection and segmentation of BMs in BB images, and applying SAM as post-processing can further enhance the precision of segmentation results.
View article: Erdheim-Chester Disease Mimicking a Malignant Pituitary Stalk Tumor With Ventricular Dissemination: A Case Report
Erdheim-Chester Disease Mimicking a Malignant Pituitary Stalk Tumor With Ventricular Dissemination: A Case Report Open
Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis characterized by multi-organ involvement, most commonly affecting the long bones, retroperitoneum, heart, lungs, skin, and central nervous system (CNS). Appr…
View article: Differences in Treatment Outcomes Depending on the Adjuvant Treatment Modality in Craniopharyngioma
Differences in Treatment Outcomes Depending on the Adjuvant Treatment Modality in Craniopharyngioma Open
Adjuvant fractionated EBRT could be effective in controlling local failure, especially in patients with non-GTR, while maintaining acceptable treatment-related toxicity.
View article: Disruption of bioenergetics enhances the radio-sensitivity of patient-derived glioblastoma tumorspheres
Disruption of bioenergetics enhances the radio-sensitivity of patient-derived glioblastoma tumorspheres Open
View article: To Use or Not to Use: Temozolomide in Elderly Patients with IDH Wild-Type MGMT Promoter Unmethylated Glioblastoma Treated with Radiotherapy
To Use or Not to Use: Temozolomide in Elderly Patients with IDH Wild-Type MGMT Promoter Unmethylated Glioblastoma Treated with Radiotherapy Open
Purpose This study aimed to identify a specific subgroup of patients among elderly glioblastoma patients aged 70 years or older with unmethylated O6-methylguanine-DNA methyltransferase promoters (eGBM-unmethylated) who would significantly …
View article: Exploring the Benefits of Herbal Medicine Composite 5 (HRMC5) for Skin Health Enhancement
Exploring the Benefits of Herbal Medicine Composite 5 (HRMC5) for Skin Health Enhancement Open
The skin, as the body’s largest organ, is vital for protecting against environmental stressors, regulating temperature, and preventing water loss. Here, we examined the potential of a mixture of five traditional Korean herbal extracts—Cimi…
View article: Synergistic combination of perphenazine and temozolomide suppresses patient-derived glioblastoma tumorspheres
Synergistic combination of perphenazine and temozolomide suppresses patient-derived glioblastoma tumorspheres Open
Background Glioblastoma (GBM), a primary malignant brain tumor, has a poor prognosis, even with standard treatments such as radiotherapy and chemotherapy. In this study, we explored the anticancer effects of the synergistic combination of …
View article: Comparison of Glioblastoma Cell Culture Platforms Based on Transcriptional Similarity with Paired Tissue
Comparison of Glioblastoma Cell Culture Platforms Based on Transcriptional Similarity with Paired Tissue Open
No standardized in vitro cell culture models for glioblastoma (GBM) have yet been established, excluding the traditional two-dimensional culture. GBM tumorspheres (TSs) have been highlighted as a good model platform for testing drug effect…
View article: Mobile robots for isolation-room hospital settings: A scenario-based preliminary study
Mobile robots for isolation-room hospital settings: A scenario-based preliminary study Open
Isolated patients pose physical challenges to medical staff owing to the need for protective gear. Additionally, communication issues arise within isolation rooms, hampering patient care. Mobile robots offer potential solutions, allowing f…
View article: RADT-28. DISRUPTION OF BIOENERGETICS ENHANCES RADIO-SENSITIVITY OF PATIENT-DERIVED GLIOBLASTOMA TUMORSPHERES
RADT-28. DISRUPTION OF BIOENERGETICS ENHANCES RADIO-SENSITIVITY OF PATIENT-DERIVED GLIOBLASTOMA TUMORSPHERES Open
INTRODUCTION Glioblastoma (GBM), the most common primary brain tumor, has been associated with poor prognosis despite various treatment modalities, the surgical resection accompanied by chemotherapy and radiotherapy. Although the importanc…
View article: STEM-19. POTENTIAL THERAPEUTIC EFFECTS OF NOVEL HISTONE DEACETYLASE INHIBITORS ON HUMAN-DERIVED GLIOBLASTOMA TUMORSPHERES
STEM-19. POTENTIAL THERAPEUTIC EFFECTS OF NOVEL HISTONE DEACETYLASE INHIBITORS ON HUMAN-DERIVED GLIOBLASTOMA TUMORSPHERES Open
BACKGROUND Histone deacetylase (HDAC) inhibitor is a promising anticancer drug targeting epigenetic alterations on tumor cells, however, failed to prove its feasibility on glioblastoma (GBM) in several trials. We developed new HDAC inhibit…
View article: Palinacousis after Cerebral Venous Thrombosis in the Temporoparietal Lobe
Palinacousis after Cerebral Venous Thrombosis in the Temporoparietal Lobe Open
Palinacousis is a rare auditory phenomenon characterized by the persistence of sounds beyond their actual duration. It has been associated with various brain conditions such as stroke, tumor, and seizure in the temporoparietal lobe. We pre…
View article: TMIC-06. GLIOBLASTOMA PROGRESSION IS PROMOTED BY C5AR1 SIGNALING THROUGH EMT INDUCTION, AND ITS BLOCKADE BY W54011 ATTENUATES MALIGNANT PHENOTYPES
TMIC-06. GLIOBLASTOMA PROGRESSION IS PROMOTED BY C5AR1 SIGNALING THROUGH EMT INDUCTION, AND ITS BLOCKADE BY W54011 ATTENUATES MALIGNANT PHENOTYPES Open
BACKGROUND Glioblastoma multiforme (GBM) is an aggressive brain tumor with poor prognosis. Tumor mesenchymal stem-like cells (tMSLCs) in GBM tissues secrete complement component 5a (C5a), which promotes tumor malignancy. This study aimed t…
View article: MODL-33. PATIENT-DERIVED GLIOBLASTOMA MINIATURE AND CANCER STEM CELL SUICIDE-INDUCING NANO-AWAKENER BASED ON IT
MODL-33. PATIENT-DERIVED GLIOBLASTOMA MINIATURE AND CANCER STEM CELL SUICIDE-INDUCING NANO-AWAKENER BASED ON IT Open
Patient-specific anti-tumor therapies can evolve by vitalizing the mother tissue-like cancer niche, cellular profile, genetic signature, and drug responsiveness. This evolution elucidated a key mechanism along with the development of the c…
View article: PATH-16. SURVIVAL ANALYSIS OF ADULT MIDLINE-LOCATED GLIOMAS: DOES THE H3K27 ALTERATION IN ADULT MIDLINE-LOCATED GLIOMAS ACTUALLY INDICATE A POOR PROGNOSIS?
PATH-16. SURVIVAL ANALYSIS OF ADULT MIDLINE-LOCATED GLIOMAS: DOES THE H3K27 ALTERATION IN ADULT MIDLINE-LOCATED GLIOMAS ACTUALLY INDICATE A POOR PROGNOSIS? Open
OBJECTIVE Although pediatric midline-located gliomas (MGs) with H3K27 alteration have been widely known to have a poor prognosis, few researchers have assessed adult MGs with H3K27 alteration. We aimed to determine the effect of H3K27 alte…
View article: Increased Risk of Hip Fracture in Patients with Acromegaly: A Nationwide Cohort Study in Korea
Increased Risk of Hip Fracture in Patients with Acromegaly: A Nationwide Cohort Study in Korea Open
Background: Acromegaly leads to various skeletal complications, and fragility fractures are emerging as a new concern in patients with acromegaly. Therefore, this study investigated the risk of fractures in Korean patients with acromegaly.…