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View article: Molecular Mechanism Discovery of Acacetin Against Cancers: Insights from Network Pharmacology and Molecular Docking
Molecular Mechanism Discovery of Acacetin Against Cancers: Insights from Network Pharmacology and Molecular Docking Open
Acacetin, a naturally occurring flavonoid, has attracted increasing attention due to its broad anticancer potential. In vitro and in vivo studies using diverse tumor models have demonstrated that acacetin modulates oncogenic signaling, sup…
View article: Molecular Mechanism Discovery of Acacetin Against Cancers: Insights from Network Pharmacology and Molecular Docking
Molecular Mechanism Discovery of Acacetin Against Cancers: Insights from Network Pharmacology and Molecular Docking Open
Acacetin, a naturally occurring flavonoid, has attracted increasing attention due to its broad anticancer potential. In vitro and in vivo studies using diverse tumor models have demonstrated that acacetin modulates oncogenic signaling, sup…
View article: Fexuprazan mitigates NSAID-induced small intestinal injury by restoring intestinal barrier integrity in mice
Fexuprazan mitigates NSAID-induced small intestinal injury by restoring intestinal barrier integrity in mice Open
Fexuprazan demonstrated protective effects against NSAID-induced small intestinal injury, while esomeprazole did not. Its ability to preserve intestinal barrier integrity, modulate inflammatory responses, and restore gut microbiota composi…
View article: Antibody–Drug Conjugates Powered by Deruxtecan: Innovations and Challenges in Oncology
Antibody–Drug Conjugates Powered by Deruxtecan: Innovations and Challenges in Oncology Open
Antibody–drug conjugates (ADCs) have revolutionized precision oncology by enabling targeted drug delivery with improved therapeutic indices. Among these, deruxtecan (DXd)-based ADCs have demonstrated remarkable efficacy across a range of c…
View article: The effects of candidate probiotic strains on the gut environment in dextran sulfate sodium-induced colitis mouse
The effects of candidate probiotic strains on the gut environment in dextran sulfate sodium-induced colitis mouse Open
View article: ATP Mediates Pyroptosis in the Intestinal Mucosal System During Colitis
ATP Mediates Pyroptosis in the Intestinal Mucosal System During Colitis Open
Damage‐associated molecular patterns (DAMPs) are molecules released from damaged or dying cells that contribute to inflammation and cell death. Extracellular ATP, a type of DAMP, has been studied primarily in the context of pyroptosis in m…
View article: Antibody-Drug Conjugates Powered by Deruxtecan: Innovations and Challenges in Oncology
Antibody-Drug Conjugates Powered by Deruxtecan: Innovations and Challenges in Oncology Open
Antibody-drug conjugates (ADCs) have revolutionized precision oncology by enabling targeted drug delivery with improved therapeutic indices. Among these, deruxtecan (DXd)-based ADCs have demonstrated remarkable efficacy across a range of c…
View article: Elucidating a Tumor‐Selective Nanoparticle Delivery Mechanism at the Colorectal Lumen–Tumor Interface for Precise Local Cancer Therapy
Elucidating a Tumor‐Selective Nanoparticle Delivery Mechanism at the Colorectal Lumen–Tumor Interface for Precise Local Cancer Therapy Open
Although various colorectal cancer (CRC)‐targeted nanoparticles have been developed to selectively deliver anticancer agents to tumor tissues, severe off‐target side effects still persist due to unwanted systemic nanoparticle distribution,…
View article: Etoposide as a Key Therapeutic Agent in Lung Cancer: Mechanisms, Efficacy, and Emerging Strategies
Etoposide as a Key Therapeutic Agent in Lung Cancer: Mechanisms, Efficacy, and Emerging Strategies Open
Topoisomerase II inhibitors, particularly etoposide, have long been integral to the treatment of lung cancer, especially small cell lung cancer. This review comprehensively examines the mechanisms of action of etoposide, its clinical effic…
View article: Topoisomerase II Inhibitors in Lung Cancer: A Comprehensive Review of Etoposide's Role and Emerging Therapeutic Strategies
Topoisomerase II Inhibitors in Lung Cancer: A Comprehensive Review of Etoposide's Role and Emerging Therapeutic Strategies Open
Topoisomerase II inhibitors, particularly etoposide, have long been integral to the treatment of lung cancer, especially small cell lung cancer. This review comprehensively examines the mechanisms of action of etoposide, its clinical effic…
View article: Myeloid-specific deletion of autotaxin inhibits rheumatoid arthritis and osteoclastogenesis
Myeloid-specific deletion of autotaxin inhibits rheumatoid arthritis and osteoclastogenesis Open
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint swelling, pain, and bone remodeling. We previously reported that autotaxin (ATX) deficiency disrupts lipid rafts in macrophages. Lipid raft disruption results…
View article: Therapeutic Potential of Pomegranate Extract for Women’s Reproductive Health and Breast Cancer
Therapeutic Potential of Pomegranate Extract for Women’s Reproductive Health and Breast Cancer Open
Pomegranate extract has potential benefits for women’s reproductive health, including fertility enhancement, menstrual cycle regulation, pregnancy support, and polycystic ovary syndrome (PCOS) treatment. It possesses antioxidant properties…
View article: Therapeutic Potential of Pomegranate Extract for Women's Reproductive Health and Breast Cancer
Therapeutic Potential of Pomegranate Extract for Women's Reproductive Health and Breast Cancer Open
Pomegranate extract has potential benefits for women's reproductive health, including fertility enhancement, menstrual cycle regulation, pregnancy support, and polycystic ovary syndrome (PCOS) treatment. It possesses antioxidant prope…
View article: Sociobiome - Individual and neighborhood socioeconomic status influence the gut microbiome in a multi-ethnic population in the US
Sociobiome - Individual and neighborhood socioeconomic status influence the gut microbiome in a multi-ethnic population in the US Open
Lower socioeconomic status (SES) is related to increased incidence and mortality due to chronic diseases in adults. Association between SES variables and gut microbiome variation has been observed in adults at the population level, suggest…
View article: Cannabinoid receptor type 1 in the aging gut regulates the mucosal permeability via miR-191-5p
Cannabinoid receptor type 1 in the aging gut regulates the mucosal permeability via miR-191-5p Open
Background Aging is associated with a broad loss of function throughout the body, and gastrointestinal (GI) dysfunction can occur with aging. The endocannabinoid (eCB) system plays a pivotal role in various GI diseases, and alterations in …
View article: Sociobiome - Individual and neighborhood socioeconomic status influence the gut microbiome in a multi-ethnic population in the US
Sociobiome - Individual and neighborhood socioeconomic status influence the gut microbiome in a multi-ethnic population in the US Open
Lower socioeconomic status (SES) is related to increased incidence and mortality due to chronic diseases in adults. Association between SES variables and gut microbiome variation has been observed in adults at the population level, suggest…
View article: <scp>pH</scp>‐sustaining nanostructured hydroxyapatite/alginate composite hydrogel for gastric protection and intestinal release of <i>Lactobacillus rhamnosus</i><scp>GG</scp>
<span>pH</span>‐sustaining nanostructured hydroxyapatite/alginate composite hydrogel for gastric protection and intestinal release of <i>Lactobacillus rhamnosus</i><span>GG</span> Open
The gut microbiome is closely linked to gastrointestinal health and disease status. Oral administration of known probiotic strains is now considered a promising therapeutic strategy, especially for refractory diseases such as inflammatory …
View article: Lactobacillus plantarum Metabolites Elicit Anticancer Effects by Inhibiting Autophagy-Related Responses
Lactobacillus plantarum Metabolites Elicit Anticancer Effects by Inhibiting Autophagy-Related Responses Open
Lactobacillus plantarum (L. plantarum) is a probiotic that has emerged as novel therapeutic agents for managing various diseases, such as cancer, atopic dermatitis, inflammatory bowel disease, and infections. In this study, we investigated…
View article: Therapeutic Potential of Bioactive Components from Scutellaria baicalensis Georgi in Inflammatory Bowel Disease and Colorectal Cancer: A Review
Therapeutic Potential of Bioactive Components from Scutellaria baicalensis Georgi in Inflammatory Bowel Disease and Colorectal Cancer: A Review Open
Scutellaria baicalensis Georgi (SBG), an herbal medicine with various biological activities, including anti-inflammatory, anticancer, antiviral, antibacterial, and antioxidant activities, is effective in treatment of colitis, hepatitis, pn…
View article: Atractylodin Ameliorates Colitis via PPARα Agonism
Atractylodin Ameliorates Colitis via PPARα Agonism Open
Atractylodin is a major compound in the rhizome of Atractylodes lancea, an oriental herbal medicine used for the treatment of gastrointestinal diseases, including dyspepsia, nausea, and diarrhea. Recent studies have shown that atractylodin…
View article: SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice
SMP30-mediated synthesis of vitamin C activates the liver PPARα/FGF21 axis to regulate thermogenesis in mice Open
View article: Mechanism of Resveratrol-Induced Programmed Cell Death and New Drug Discovery against Cancer: A Review
Mechanism of Resveratrol-Induced Programmed Cell Death and New Drug Discovery against Cancer: A Review Open
Resveratrol (3,5,4′-trihydroxy-trans-stilbene), a polyphenol found in grapes, red wine, peanuts, and apples, has been reported to exhibit a wide range of biological and pharmacological properties. In addition, resveratrol has been reported…
View article: Mechanism of Bile Acid-Induced Programmed Cell Death and Drug Discovery against Cancer: A Review
Mechanism of Bile Acid-Induced Programmed Cell Death and Drug Discovery against Cancer: A Review Open
Bile acids are major signaling molecules that play a significant role as emulsifiers in the digestion and absorption of dietary lipids. Bile acids are amphiphilic molecules produced by the reaction of enzymes with cholesterol as a substrat…
View article: Modulation of Intestinal Epithelial Permeability via Protease-Activated Receptor-2-Induced Autophagy
Modulation of Intestinal Epithelial Permeability via Protease-Activated Receptor-2-Induced Autophagy Open
Protease-activated receptor 2 (PAR2) alleviates intestinal inflammation by upregulating autophagy. PAR2 also modulates tight junctions through β-arrestin signaling. Therefore, we investigated the effect of PAR2-induced autophagy on intesti…
View article: MHY2245, a Sirtuin Inhibitor, Induces Cell Cycle Arrest and Apoptosis in HCT116 Human Colorectal Cancer Cells
MHY2245, a Sirtuin Inhibitor, Induces Cell Cycle Arrest and Apoptosis in HCT116 Human Colorectal Cancer Cells Open
Sirtuins (SIRTs), which are nicotinamide adenine dinucleotide-dependent class III histone deacetylases, regulate cell division, survival, and senescence. Although sirtinol, a synthetic SIRT inhibitor, is known to exhibit antitumor effects,…
View article: CHRONIC COLITIS ALTERS BRAIN ACTIVITY BY INDUCING HMGB1-MEDIATED PYROPTOSIS IN MICE
CHRONIC COLITIS ALTERS BRAIN ACTIVITY BY INDUCING HMGB1-MEDIATED PYROPTOSIS IN MICE Open
View article: Table of Contents
Table of Contents Open
View article: Gastrointestinal symptoms in four major racial/ethnic groups of midlife women: race/ethnicity and menopausal status.
Gastrointestinal symptoms in four major racial/ethnic groups of midlife women: race/ethnicity and menopausal status. Open
This study supports the association of race/ethnicity and menopausal status to GI symptoms experienced during the menopausal transition.
View article: Chronic Intestinal Inflammation Suppresses Brain Activity by Inducing Neuroinflammation in Mice
Chronic Intestinal Inflammation Suppresses Brain Activity by Inducing Neuroinflammation in Mice Open
View article: pH-Responsive Alginate-Based Microparticles for Colon-Targeted Delivery of Pure Cyclosporine A Crystals to Treat Ulcerative Colitis
pH-Responsive Alginate-Based Microparticles for Colon-Targeted Delivery of Pure Cyclosporine A Crystals to Treat Ulcerative Colitis Open
Cyclosporine A (CsA) is a potent immunosuppressant for treating ulcerative colitis (UC). However, owing to severe systemic side effects, CsA application in UC therapy remains limited. Herein, a colon-targeted drug delivery system consistin…