Juyoung Yoon
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View article: Golgi‐Targeted Viscosity Fluorescent Probe for Monitoring Acute Lung Injury
Golgi‐Targeted Viscosity Fluorescent Probe for Monitoring Acute Lung Injury Open
Acute lung injury (ALI) is a severe respiratory disorder driven by uncontrolled inflammation, where early diagnosis and intervention are critical. Recent evidence implicates Golgi apparatus dysfunction in ALI progression, but its biophysic…
View article: Synergistic chemodynamic and metabolic reprogramming-based cancer therapy by CuO@HA nanozymes with oxygen vacancy
Synergistic chemodynamic and metabolic reprogramming-based cancer therapy by CuO@HA nanozymes with oxygen vacancy Open
View article: Activatable smart contrast agents for photoacoustic imaging
Activatable smart contrast agents for photoacoustic imaging Open
Photoacoustic imaging (PAI) uniquely merges the molecular contrast of optical absorption with the centimeter‐scale penetration afforded by ultrasound detection, enabling noninvasive visualization of deep physiology beyond the reach of pure…
View article: Naphthalimide‐Based Type‐I Nano‐Photosensitizers for Enhanced Antitumor Photodynamic Therapy: H <sub>2</sub> S Synergistically Regulates PeT and Self‐Assembly
Naphthalimide‐Based Type‐I Nano‐Photosensitizers for Enhanced Antitumor Photodynamic Therapy: H <sub>2</sub> S Synergistically Regulates PeT and Self‐Assembly Open
Photodynamic therapy (PDT) relies on a combination of light and photosensitizers (PSs) to achieve local control over cancerous lesions. However, it is subject to limitations, including tumor hypoxia, low tumor targeting, off‐target phototo…
View article: Targeting the hypoxia signaling pathway with nanomedicine to reverse immunotherapy resistance
Targeting the hypoxia signaling pathway with nanomedicine to reverse immunotherapy resistance Open
Immunotherapy has emerged as a major therapeutic strategy for cancer; however, immunotherapy resistance remains a significant challenge. Hypoxia, a key hallmark of the tumor microenvironment resulting from the imbalance between the high ox…
View article: A lipid droplet‐selective fluorescent probe for real‐time imaging and polarity sensing
A lipid droplet‐selective fluorescent probe for real‐time imaging and polarity sensing Open
Lipid droplets (LDs) are dynamic organelles involved in lipid storage and metabolism, interacting with other organelles to maintain cellular homeostasis. Changes in LD number, size, or polarity are linked to metabolic disorders such as fat…
View article: A Photon‐Driven Unimolecular Immunostimulant for Self‐Amplified Pyroptosis and cGAS‐STING Pathway by Destroying the Pyroptosis Checkpoint
A Photon‐Driven Unimolecular Immunostimulant for Self‐Amplified Pyroptosis and cGAS‐STING Pathway by Destroying the Pyroptosis Checkpoint Open
Immunotherapy is a groundbreaking approach for clinically treating tumors, but its effectiveness is hindered by the tumor's immunosuppressive environment and lack of immune cell infiltration, enabling tumors to evade the immune system. Alt…
View article: Exploring the Photophysical Processes of an Al<sup>3+</sup> Sensor Based on Schiff Base
Exploring the Photophysical Processes of an Al<sup>3+</sup> Sensor Based on Schiff Base Open
Schiff bases are commonly used as building blocks in the development of turn‐on sensors for Al 3+ detection. The isomerization of the CN bond in Schiff bases is generally believed to induce fluorescence quenching. Inhibiting this isomeriz…
View article: Regioisomeric Engineering of Sterically Hindered Bright Near-Infrared Paraptosis Agents for Chemo-Photodynamic Therapy
Regioisomeric Engineering of Sterically Hindered Bright Near-Infrared Paraptosis Agents for Chemo-Photodynamic Therapy Open
Paraptosis emerges as a new promising form of programmed non-apoptotic cell death in chemotherapeutic anticancer therapy. However, current paraptosis agents face critical challenges, including poor targeting specificity, limited imaging ca…
View article: A Hypoxia‐Triggered Bioreduction of Hydrophilic Type I Photosensitizer for Switchable In Vivo Photoacoustic Imaging and High‐Specificity Cancer Phototherapy
A Hypoxia‐Triggered Bioreduction of Hydrophilic Type I Photosensitizer for Switchable In Vivo Photoacoustic Imaging and High‐Specificity Cancer Phototherapy Open
Considering that hypoxia is strongly connected with tumor proliferation, metastasis, invasion, and drug resistance, it is of significant implication for alleviating the effects of hypoxia in tumor treatment. The negligible oxygen‐dependent…
View article: Tumor‐Targeted Exosome‐Based Heavy Atom‐Free Nanosensitizers With Long‐Lived Excited States for Safe and Effective Sono‐Photodynamic Therapy of Solid Tumors
Tumor‐Targeted Exosome‐Based Heavy Atom‐Free Nanosensitizers With Long‐Lived Excited States for Safe and Effective Sono‐Photodynamic Therapy of Solid Tumors Open
Theranostic nanosensitizers with combined near‐infrared (NIR) fluorescence imaging and sono‐photodynamic effects have great potential for use in the personalized treatment of deep‐seated tumors. However, developing effective nanosensitizer…
View article: Magnetic Control of Multiscale Ligand Nanoarchitecture Regulates Stem Cell Fate
Magnetic Control of Multiscale Ligand Nanoarchitecture Regulates Stem Cell Fate Open
Native tissues exhibit hierarchical structures of anisotropically arranged extracellular matrix that dynamically regulate stem cells and tissue function. However, neither multiscale nano‐anisotropy nor dynamic anisotropy control have been …
View article: Supramolecular Synthesis of Dithienylethene‐Albumin Complexes for Enhanced Photoswitching In Photoacoustic Imaging‐Guided Near‐Infrared Photothermal Therapy
Supramolecular Synthesis of Dithienylethene‐Albumin Complexes for Enhanced Photoswitching In Photoacoustic Imaging‐Guided Near‐Infrared Photothermal Therapy Open
Photoswitchable molecules can transit between two distinct isomers, enabling them to perform highly controllable imaging and therapeutic functions under certain laser irradiation. Dithienylethenes (DTEs), a class of photoswitchable molecul…
View article: A Nanotherapeutic Agent for Synergistic Tumor Therapy: Co‐Activation of Photochemical‐Biological Effects
A Nanotherapeutic Agent for Synergistic Tumor Therapy: Co‐Activation of Photochemical‐Biological Effects Open
Single‐mode photodynamic therapy (PDT) based on photochemical reactions is limited by the tumor microenvironment, which reduces the ablation efficiency for solid tumors. Making it vital to seek ways to improve the tumor therapeutic effect.…
View article: Transferrin-Mediated Nanophotosensitizer to Enhance Phototherapy with Photoacoustic Imaging Under Hypoxia
Transferrin-Mediated Nanophotosensitizer to Enhance Phototherapy with Photoacoustic Imaging Under Hypoxia Open
View article: Integrin‐Targeted, Activatable Nanophototherapeutics for Immune Modulation: Enhancing Photoimmunotherapy Efficacy in Prostate Cancer Through Macrophage Reprogramming
Integrin‐Targeted, Activatable Nanophototherapeutics for Immune Modulation: Enhancing Photoimmunotherapy Efficacy in Prostate Cancer Through Macrophage Reprogramming Open
Prostate cancer is an epithelial malignancy with a high incidence among elderly men. Photochemistry‐based dye photodrugs (known as photosensitizers) offer a promising clinical approach for treating tumors. These agents work by inducing imm…
View article: A One Stone Three Birds Paradigm of Photon‐Driven Pyroptosis Dye for Amplifying Tumor Immunotherapy
A One Stone Three Birds Paradigm of Photon‐Driven Pyroptosis Dye for Amplifying Tumor Immunotherapy Open
Activating the pyroptosis pathway of tumor cells by photodynamic therapy (PDT) for immunogenic cell death (ICD) is considered a valid strategy in pursuit of antitumor immunotherapy, but it remains a huge challenge due to the lack of reliab…
View article: Cyclization-Induced Nirf and Functional Specificity: Nir Probe Based on Phenothiazine Core for Ultra-Fast Detecting Mitochondrial Hclo During Cell Ferroptosis
Cyclization-Induced Nirf and Functional Specificity: Nir Probe Based on Phenothiazine Core for Ultra-Fast Detecting Mitochondrial Hclo During Cell Ferroptosis Open
View article: Autophagy-Responsive Photosensitizers for Autophagic Activity Monitoring and Photodynamic Therapy
Autophagy-Responsive Photosensitizers for Autophagic Activity Monitoring and Photodynamic Therapy Open
View article: Membrane Disruption-Facilitated Antimicrobial Activity to Eliminate Drug-Resistant Pathogens: A Rational Strategy to Optimize Nano Photodrugs Assisted by Molecular Dynamics Simulations
Membrane Disruption-Facilitated Antimicrobial Activity to Eliminate Drug-Resistant Pathogens: A Rational Strategy to Optimize Nano Photodrugs Assisted by Molecular Dynamics Simulations Open
View article: Enhancing biosafety in photodynamic therapy: progress and perspectives
Enhancing biosafety in photodynamic therapy: progress and perspectives Open
This review highlights the uniqueness of smart photosensitizers to increase the efficacy of photodynamic therapy while enhancing treatment biosafety, as well as their future prospects in clinical applications.
View article: Naphthalene-based fluorescent probes for glutathione and their applications in living cells and patients with sepsis: Erratum
Naphthalene-based fluorescent probes for glutathione and their applications in living cells and patients with sepsis: Erratum Open
[This corrects the article DOI: 10.7150/thno.22252.].
View article: Leveraging an Electron-Acceptor Engineering Strategy to Regulate Excitation Dynamics of Dyes for Devising Ideal Phototherapeutic Agents in Synergistic Photodynamic/Mild-Photothermal Tumor Therapy
Leveraging an Electron-Acceptor Engineering Strategy to Regulate Excitation Dynamics of Dyes for Devising Ideal Phototherapeutic Agents in Synergistic Photodynamic/Mild-Photothermal Tumor Therapy Open
View article: Photon‐Driven Dye Induction Pyroptosis: An Emerging Anti‐Tumor Immunotherapy Paradigm
Photon‐Driven Dye Induction Pyroptosis: An Emerging Anti‐Tumor Immunotherapy Paradigm Open
Photoimmunotherapy represents a novel and promising modality in anti‐tumor immunotherapy, offering new hope in the realm of cancer treatment due to its distinctive mechanism and substantial therapeutic efficacy. This innovative approach sy…
View article: Rational Design of an Activatable Near‐Infrared Fluorogenic Platform for In Vivo Orthotopic Tumor Imaging and Resection
Rational Design of an Activatable Near‐Infrared Fluorogenic Platform for In Vivo Orthotopic Tumor Imaging and Resection Open
Rational and effective design of a universal near‐infrared (NIR) light‐absorbed platform employed to prepare diverse activatable NIR fluorogenic probes for in vivo imaging and the imaging‐guided tumor resection remains less exploited but h…
View article: Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine
Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine Open
Biopsy, including tissue and liquid biopsy, offers comprehensive and real-time physiological and pathological information for disease detection, diagnosis, and monitoring. Fluorescent probes are frequently selected to obtain adequate infor…
View article: Harnessing Dual Phototherapy and Immune Activation for Cancer Treatment: The Development and Application of BODIPY@F127 Nanoparticles
Harnessing Dual Phototherapy and Immune Activation for Cancer Treatment: The Development and Application of BODIPY@F127 Nanoparticles Open
Conventional phototherapeutic agents are typically used in either photodynamic therapy (PDT) or photothermal therapy (PTT). However, efficacy is often hindered by hypoxia and elevated levels of heat shock proteins in the tumor microenviron…
View article: Inside Front Cover: Supramolecular phthalocyanine assemblies‐enhanced synergistic photodynamic and photothermal therapy guided by photoacoustic imaging
Inside Front Cover: Supramolecular phthalocyanine assemblies‐enhanced synergistic photodynamic and photothermal therapy guided by photoacoustic imaging Open
View article: Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy
Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy Open
Cancer treatment requires precise tumor‐specific targeting at specific sites that allows for high‐resolution diagnostic imaging and long‐term patient‐tailorable cancer therapy; while, minimizing side effects largely arising from non‐target…
View article: A novel AIE-NIR-II nano-contrast agent for monitoring and evaluating kidney transplant
A novel AIE-NIR-II nano-contrast agent for monitoring and evaluating kidney transplant Open