Eun‐A Ko
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View article: Targeting the pentose phosphate pathway mitigates graft-versus-host disease by rewiring alloreactive T cell metabolism
Targeting the pentose phosphate pathway mitigates graft-versus-host disease by rewiring alloreactive T cell metabolism Open
Glycolysis fuels cytotoxic allogeneic T cells in acute graft-versus-host disease (aGvHD), but the downstream role of glucose metabolism in modulating aGvHD remains unclear. Targeting glycolysis or glucose receptors is toxic. Therefore, we …
View article: Mitochondrial Metabolic Reprogramming of Cortical Neurons by Prenatal Exposure to Corticosterone: A Shift from ATP Synthesis to Membrane Potential Maintenance
Mitochondrial Metabolic Reprogramming of Cortical Neurons by Prenatal Exposure to Corticosterone: A Shift from ATP Synthesis to Membrane Potential Maintenance Open
Mitochondrial bioenergetics plays a fundamental role in neuronal development and function. Prenatal exposure to corticosterone in rats (Corti. Pup) has previously been shown to cause delayed neurodevelopment and synaptic plasticity deficit…
View article: Co-Expression of TWIK-Related Acid-Sensitive K+ Channel 1 (TASK-1/KCNK3) and Platelet-Derived Growth Factor Receptor Alpha (PDGFRα/Pdgfra) in Adult Mouse Ovary
Co-Expression of TWIK-Related Acid-Sensitive K+ Channel 1 (TASK-1/KCNK3) and Platelet-Derived Growth Factor Receptor Alpha (PDGFRα/Pdgfra) in Adult Mouse Ovary Open
Background/Objectives: Platelet-derived growth factor receptor alpha (PDGFRα) is a receptor involved in cell growth and differentiation, with unclear roles in ovarian tissues and potential interactions with KCNK3 (potassium two-pore domain…
View article: Co-expression of TWIK-Related acid-Sensitive K+ Channel 1 (TASK-1/KCNK3) and Platelet-Derived Growth Factor Receptor Alpha (PDGFRα/Pdgfra) in Adult Mouse Ovary
Co-expression of TWIK-Related acid-Sensitive K+ Channel 1 (TASK-1/KCNK3) and Platelet-Derived Growth Factor Receptor Alpha (PDGFRα/Pdgfra) in Adult Mouse Ovary Open
Background/Objectives: Platelet-derived growth factor receptor alpha (PDGFRα) is a receptor involved in cell growth and differentiation, with unclear roles in ovarian tissues and potential interactions with potassium two pore domain channe…
View article: Transcriptomic Alteration in the Brain and Gut of Offspring Following Prenatal Exposure to Corticosterone
Transcriptomic Alteration in the Brain and Gut of Offspring Following Prenatal Exposure to Corticosterone Open
Maternal stress during pregnancy can profoundly affect offspring health, increasing the risk of psychiatric disorders, metabolic diseases, and gastrointestinal problems. In this study, the effects of high prenatal corticosterone exposure o…
View article: <scp>HDAC4</scp>/5 Inhibitor, <scp>LMK</scp>‐235 Improves Animal Voluntary Movement in <scp>MPTP</scp>‐Induced Parkinson's Disease Model
<span>HDAC4</span>/5 Inhibitor, <span>LMK</span>‐235 Improves Animal Voluntary Movement in <span>MPTP</span>‐Induced Parkinson's Disease Model Open
Oxidation of dopamine can cause various side effects, which ultimately leads to cell death and contributes to Parkinson's disease (PD). To counteract dopamine oxidation, newly synthesized dopamine is quickly transported into vesicles via v…
View article: The aging-dependent contribution of brain-derived neurotrophic factor (BDNF) to psychiatric and neurodegenerative disorders
The aging-dependent contribution of brain-derived neurotrophic factor (BDNF) to psychiatric and neurodegenerative disorders Open
View article: Transcriptomic evidence for atopic dermatitis as a systemic disease in NC/Nga mice
Transcriptomic evidence for atopic dermatitis as a systemic disease in NC/Nga mice Open
View article: Roles of PDGF/PDGFR signaling in various organs
Roles of PDGF/PDGFR signaling in various organs Open
Platelet-derived growth factors (PDGFs) ligands and their corresponding receptors, PDGF receptor (PDGFR)α and PDGFRβ, play a crucial role in controlling diverse biological functions, including cell growth, viability and migration. These gr…
View article: Insight into noncanonical small noncoding RNAs in Influenza A virus infection
Insight into noncanonical small noncoding RNAs in Influenza A virus infection Open
Influenza A virus (IAV) induces acute respiratory infections in birds and various mammals, including humans, and presents a significant global public health concern, with considerable economic consequences. Recently, researchers have shown…
View article: Analysis of platelet-derived growth factor receptor alpha expression in adult mouse testis
Analysis of platelet-derived growth factor receptor alpha expression in adult mouse testis Open
Background: Platelet-derived growth factor receptor alpha (PDGFRα) is essential for various biological processes, including fetal Leydig cell differentiation. The PDGFRαEGFP mouse model, which expresses an eGFP fusion gene under the native…
View article: Corrigendum to: Cardioprotection <i>via</i> mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart
Corrigendum to: Cardioprotection <i>via</i> mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart Open
Jehee Jang, Ki-Woon Kang, Young-Won Kim, Seohyun Jeong, Jaeyoon Park, Jihoon Park, Jisung Moon, Junghyun Jang, Seohyeon Kim, Sunghun Kim, Sungjoo Cho, Yurim Lee, Hyoung Kyu Kim, Jin Han, Eun-A Ko, Sung-Cherl Jung, Jung-Ha Kim, and Jae-Hong…
View article: Cardioprotection via mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart
Cardioprotection via mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart Open
In addition to cellular damage, ischemia-reperfusion (IR) injury induces substantial damage to the mitochondria and endoplasmic reticulum. In this study, we sought to determine whether impaired mitochondrial function owing to IR could be r…
View article: Prenatal treatment with corticosterone via maternal injection induces learning and memory impairments via delaying postsynaptic development in hippocampal <scp>CA1</scp> neurons of rats
Prenatal treatment with corticosterone via maternal injection induces learning and memory impairments via delaying postsynaptic development in hippocampal <span>CA1</span> neurons of rats Open
Previously, we reported that prenatal exposure to high corticosterone induced attention‐deficit hyperactivity disorder (ADHD)‐like behaviors with cognitive deficits after weaning. In the present study, cellular mechanisms underlying cortis…
View article: Insight into the transcriptome of the small intestine in pups born from corticosterone-treated rats
Insight into the transcriptome of the small intestine in pups born from corticosterone-treated rats Open
View article: Age-dependent expression of ion channel genes in rat
Age-dependent expression of ion channel genes in rat Open
Ion channels regulate a large number of cellular functions and their functional role in many diseases makes them potential therapeutic targets. Given their diverse distribution across multiple organs, the roles of ion channels, particularl…
View article: <i>GPCR</i> genes as a predictor of glioma severity and clinical outcome
<i>GPCR</i> genes as a predictor of glioma severity and clinical outcome Open
Objective To undertake a comprehensive analysis of the differential expression of the G protein-coupled receptor ( GPCR) genes in order to construct a GPCR gene signature for human glioma prognosis. Methods This current study investigated …
View article: Testosterone secretion is affected by receptor tyrosine kinase c-Kit and anoctamin 1 activation in mouse Leydig cells
Testosterone secretion is affected by receptor tyrosine kinase c-Kit and anoctamin 1 activation in mouse Leydig cells Open
Receptor tyrosine kinase c-Kit, a marker found on interstitial cells of Cajal (ICCs), is expressed in Leydig cells, which are testicular interstitial cells. The expression of other ICC markers has not yet been reported. In this study, we i…
View article: Targeting Catecholamines to Develop New Drugs for Attention Deficit Hyperactivity Disorder
Targeting Catecholamines to Develop New Drugs for Attention Deficit Hyperactivity Disorder Open
The prevalence of attention deficit hyperactivity disorder (ADHD), a developmental neuropsychiatric disorder, is high among children and adolescents. The pathogenesis of ADHD is mediated with genetic, biological, and environmental factors.…
View article: Transcriptomic insight into the translational value of two murine models in human atopic dermatitis
Transcriptomic insight into the translational value of two murine models in human atopic dermatitis Open
View article: Prenatal Exposure to High Cortisol Induces ADHD-like Behaviors with Delay in Spatial Cognitive Functions during the Post-weaning Period in Rats
Prenatal Exposure to High Cortisol Induces ADHD-like Behaviors with Delay in Spatial Cognitive Functions during the Post-weaning Period in Rats Open
High levels of cortisol in blood are frequently observed in patients with major depressive disorders and increased cortisol level induces depressivelike symptoms in animal models. However, it is still unclear whether maternal cortisol leve…
View article: Nobiletin Exhibits Neuroprotective Effects against Mitochondrial Complex I Inhibition via Regulating Apoptotic Signaling
Nobiletin Exhibits Neuroprotective Effects against Mitochondrial Complex I Inhibition via Regulating Apoptotic Signaling Open
Nobiletin, a polymethoxylated flavonoid found in citrus, has been studied because of its modulatory functions in cellular signaling cascades, and effects to prevent mitochondrial calcium overload and neuronal cell death. Particularly, we p…
View article: Expression of Alpha-type Platelet-derived Growth Factor Receptor–influenced Genes Predicts Clinical Outcome in Glioma
Expression of Alpha-type Platelet-derived Growth Factor Receptor–influenced Genes Predicts Clinical Outcome in Glioma Open
View article: Expression of potassium channel genes predicts clinical outcome in lung cancer
Expression of potassium channel genes predicts clinical outcome in lung cancer Open
Lung cancer is the most common cause of cancer deaths worldwide and several molecular signatures have been developed to predict survival in lung cancer. Increasing evidence suggests that proliferation and migration to promote tumor growth …
View article: SPORTS1.0: A Tool for Annotating and Profiling Non-coding RNAs Optimized for rRNA- and tRNA-derived Small RNAs
SPORTS1.0: A Tool for Annotating and Profiling Non-coding RNAs Optimized for rRNA- and tRNA-derived Small RNAs Open
High-throughput RNA-seq has revolutionized the process of small RNA (sRNA) discovery, leading to a rapid expansion of sRNA categories. In addition to the previously well-characterized sRNAs such as microRNAs (miRNAs), Piwi-interacting RNA …
View article: SPORTS1.0: A Tool for Annotating and Profiling Non-Coding RNAs Optimized for rRNA- and tRNA-Derived Small RNAs
SPORTS1.0: A Tool for Annotating and Profiling Non-Coding RNAs Optimized for rRNA- and tRNA-Derived Small RNAs Open
High-throughput RNA-seq has revolutionized the process of small RNA (sRNA) discovery, leading to a rapid expansion of sRNA categories. In addition to the previously well-characterized sRNAs such as microRNAs (miRNAs), piwi-interacting RNAs…
View article: Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility
Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility Open
Microtubules position ion channels close to each other to ensure autoregulation of vascular tone in cerebral arteries.
View article: The angiotensin II receptor type 1b is the primary sensor of intraluminal pressure in cerebral artery smooth muscle cells
The angiotensin II receptor type 1b is the primary sensor of intraluminal pressure in cerebral artery smooth muscle cells Open
Key points The angiotensin II receptor type 1b (AT 1 R b ) is the primary sensor of intraluminal pressure in cerebral arteries. Pressure or membrane‐stretch induced stimulation of AT 1 R b activates the TRPM4 channel and results in inward …
View article: Additional file 2: Table S1. of Ethylene induces combinatorial effects of histone H3 acetylation in gene expression in Arabidopsis
Additional file 2: Table S1. of Ethylene induces combinatorial effects of histone H3 acetylation in gene expression in Arabidopsis Open
Primers for ChIP-qPCR and qPCR. Table S2. list of genome wide genes with differential histone markers in seedlings treated with air. Table S3. list of genome wide genes with differential histone markers in seedlings treated with ethylene. …
View article: The role of TASK-1 and TRPV1 channels in the male reproductive system
The role of TASK-1 and TRPV1 channels in the male reproductive system Open
The mammalian testis is a highly organized organ essential for male reproduction. Its structure comprises seminiferous tubules lined with Sertoli cells, which support spermatogenesis, surrounded by peritubular myoid cells. Within the conne…