Eunice Machuka
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View article: Wastewater Genomic Epidemiology Reveals Socioeconomic Patterns of Pathogen Diversity and Antimicrobial Resistance in Nairobi, Kenya
Wastewater Genomic Epidemiology Reveals Socioeconomic Patterns of Pathogen Diversity and Antimicrobial Resistance in Nairobi, Kenya Open
View article: Next Generation Sequencing and Genetic Analyses Reveal Factors Driving Evolution of Sweetpotato Viruses in Uganda
Next Generation Sequencing and Genetic Analyses Reveal Factors Driving Evolution of Sweetpotato Viruses in Uganda Open
Sweetpotato (Ipomoea batatas L.) is an essential food crop globally, especially for farmers facing resource limitations. Like other crops, sweetpotato cultivation faces significant production challenges due to viral infections. This study …
View article: Complete Genome Sequencing and Comparative Phylogenomics of Nine African Swine Fever Virus (ASFV) Isolates of the Virulent East African p72 Genotype IX without Viral Sequence Enrichment
Complete Genome Sequencing and Comparative Phylogenomics of Nine African Swine Fever Virus (ASFV) Isolates of the Virulent East African p72 Genotype IX without Viral Sequence Enrichment Open
African swine fever virus (ASFV) is endemic to African wild pigs (Phacochoerus and Potamochoerus), in which viral infection is asymptomatic, and Ornithodoros soft ticks. However, ASFV causes a lethal disease in Eurasian domestic pigs (Sus …
View article: Analysis of spatial and temporal risk of Peste des Petits Ruminants Virus (PPRV) outbreaks in endemic settings: A scoping review
Analysis of spatial and temporal risk of Peste des Petits Ruminants Virus (PPRV) outbreaks in endemic settings: A scoping review Open
Background Sustained Peste des petits ruminants (PPR) circulation, as evidenced by surveillance, shows PPR endemicity in Africa and Asia. Regional transmission of PPR is enabled by joining numerous epidemiological factors. Spatial, spatiot…
View article: Wastewater based genomic surveillance reveals circulating pathogenic bacteria and associated resistome in Nairobi-Kenya sewerage system
Wastewater based genomic surveillance reveals circulating pathogenic bacteria and associated resistome in Nairobi-Kenya sewerage system Open
Wastewater-based surveillance (WBS) has become a useful public health tool as an early warning system revealing emergence/re-emergence of pathogenic diseases and spread of antimicrobial resistance (AMR). WBS is crucial in development of ra…
View article: Major Histocompatibility Complex Region and Diversity of the Local Chicken Populations In Niger
Major Histocompatibility Complex Region and Diversity of the Local Chicken Populations In Niger Open
Introduction: The major histocompatibility complex (MHC) of chicken is highly polymorphic, and it is linked to several disease resistance or susceptibility traits. Therefore, the current study aimed to analyze the genetic diversity in the …
View article: DNA sequencing reveals high arbuscular mycorrhizal fungi diversity in the rhizosphere soil of Prunus africana trees in fragmented Afromontane forests
DNA sequencing reveals high arbuscular mycorrhizal fungi diversity in the rhizosphere soil of Prunus africana trees in fragmented Afromontane forests Open
View article: Diversity and functional analysis of rumen and fecal microbial communities associated with dietary changes in crossbreed dairy cattle
Diversity and functional analysis of rumen and fecal microbial communities associated with dietary changes in crossbreed dairy cattle Open
The objective of this study was to investigate the effect of varying roughage and concentrate proportions, in diet of crossbreed dairy cattle, on the composition and associated functional genes of rumen and fecal microbiota. We also explor…
View article: Illumina MiSeq sequencing reveals high arbuscular mycorrhizal fungi diversity in the rhizosphere soil of Prunus africana trees in fragmented Afromontane forests
Illumina MiSeq sequencing reveals high arbuscular mycorrhizal fungi diversity in the rhizosphere soil of Prunus africana trees in fragmented Afromontane forests Open
Purpose Arbuscular mycorrhizal fungi (AMF) play a key role in the phytochemical modulation of medicinal plant species, besides their ecological role in shaping plant communities. Knowledge about the diversity and structure of AMF species a…
View article: Diversity and functional analysis of rumen and fecal microbial communities associated with dietary changes in crossbreed dairy cattle
Diversity and functional analysis of rumen and fecal microbial communities associated with dietary changes in crossbreed dairy cattle Open
The objective of this study was to investigate the effect of varying roughage and concentrate proportions, in diet of crossbreed dairy cattle, on the composition and associated functional genes of rumen and fecal microbiota. We also explor…
View article: Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033)
Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033) Open
Background African swine fever (ASF) is a lethal hemorrhagic disease affecting domestic pigs resulting in up to 100% mortality rates caused by the ASF virus (ASFV). The locally-adapted pigs in South-western Kenya have been reported to be r…
View article: Detection of Antimicrobial Resistance, Pathogenicity, and Virulence Potentials of Non-Typhoidal Salmonella Isolates at the Yaounde Abattoir Using Whole-Genome Sequencing Technique
Detection of Antimicrobial Resistance, Pathogenicity, and Virulence Potentials of Non-Typhoidal Salmonella Isolates at the Yaounde Abattoir Using Whole-Genome Sequencing Technique Open
One of the crucial public health problems today is the emerging and re-emerging of multidrug-resistant (MDR) bacteria coupled with a decline in the development of new antimicrobials. Non-typhoidal Salmonella (NTS) is classified among the M…
View article: Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (Ken-1033)
Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (Ken-1033) Open
Background: African swine fever (ASF) is a lethal hemorrhagic disease affecting domestic pigs resulting in up to 100 % mortality rates caused by the ASF virus (ASFV). The locally-adapted pigs in South-western Kenya have been reported to be…
View article: Haplotype analysis of the mitochondrial DNA <i>d‐loop</i> region reveals the maternal origin and historical dynamics among the indigenous goat populations in east and west of the Democratic Republic of Congo
Haplotype analysis of the mitochondrial DNA <i>d‐loop</i> region reveals the maternal origin and historical dynamics among the indigenous goat populations in east and west of the Democratic Republic of Congo Open
This study aimed at assessing haplotype diversity and population dynamics of three Congolese indigenous goat populations that included Kasai goat (KG), small goat (SG), and dwarf goat (DG) of the Democratic Republic of Congo (DRC). The 116…
View article: Aetiology of lobar pneumonia determined by multiplex molecular analyses of lung and pleural aspirate specimens in the Gambia: findings from population-based pneumonia surveillance
Aetiology of lobar pneumonia determined by multiplex molecular analyses of lung and pleural aspirate specimens in the Gambia: findings from population-based pneumonia surveillance Open
Objectives To determine the causes of lobar pneumonia in rural Gambia. Design and setting Population-based pneumonia surveillance at seven peripheral health facilities and two regional hospitals in rural Gambia. 7-valent pneumococcal conju…
View article: Additional file 10 of Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033)
Additional file 10 of Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033) Open
Additional file 10.
View article: Additional file 5 of Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033)
Additional file 5 of Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033) Open
Additional file 5.
View article: Additional file 7 of Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033)
Additional file 7 of Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033) Open
Additional file 7.
View article: Additional file 8 of Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033)
Additional file 8 of Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033) Open
Additional file 8.
View article: Additional file 4 of Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033)
Additional file 4 of Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033) Open
Additional file 4.
View article: Additional file 9 of Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033)
Additional file 9 of Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033) Open
Additional file 9.
View article: Additional file 6 of Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033)
Additional file 6 of Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033) Open
Additional file 6.
View article: Detection of antimicrobial resistance, pathogenicity, and virulence potentials of non-typhoidal <i>Salmonella</i> isolates at the Yaounde abattoir using whole genome sequencing technique
Detection of antimicrobial resistance, pathogenicity, and virulence potentials of non-typhoidal <i>Salmonella</i> isolates at the Yaounde abattoir using whole genome sequencing technique Open
One of the crucial public health problems today is emerging and re-emerging of multidrug-resistant bacterial pathogens coupled with a decline in the development of new antimicrobials. Non-typhoidal Salmonella is classified among the multid…
View article: Molecular survey of cattle ticks in Burundi: First report on the presence of the invasive Rhipicephalus microplus tick
Molecular survey of cattle ticks in Burundi: First report on the presence of the invasive Rhipicephalus microplus tick Open
A recent research study on prevalence of tick-borne pathogens in Burundi reported high prevalence and endemicity of Theileria parva , Anaplasma marginale and Babesia bigemina infections in cattle. Detailed information about tick species in…
View article: African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa
African Swine Fever Virus (ASFV): Biology, Genomics and Genotypes Circulating in Sub-Saharan Africa Open
African swine fever (ASF) is a highly infectious and fatal haemorrhagic disease of pigs that is caused by a complex DNA virus of the genus Asfivirus and Asfarviridae African suids family. The disease is among the most devastating pig disea…
View article: Comparative Analysis of SLA-1, SLA-2, and DQB1 Genetic Diversity in Locally-Adapted Kenyan Pigs and Their Wild Relatives, Warthogs
Comparative Analysis of SLA-1, SLA-2, and DQB1 Genetic Diversity in Locally-Adapted Kenyan Pigs and Their Wild Relatives, Warthogs Open
Swine leukocyte antigen (SLA) plays a central role in controlling the immune response by discriminating self and foreign antigens and initiating an immune response. Studies on SLA polymorphism have demonstrated associations between SLA all…
View article: The Etiology of Childhood Pneumonia in The Gambia
The Etiology of Childhood Pneumonia in The Gambia Open
Background: Pneumonia remains the leading cause of death in young children globally. The changing epidemiology of pneumonia requires up-to-date data to guide both case management and prevention programs. The Gambia study site contributed a…
View article: Aetiology of Lobar Pneumonia Determined by Multiplex Molecular Analyses of Lung and Pleural Aspirate Specimens in The Gambia
Aetiology of Lobar Pneumonia Determined by Multiplex Molecular Analyses of Lung and Pleural Aspirate Specimens in The Gambia Open
Background Pneumonia aetiology generally relies on insensitive blood cultures or an assumption that organisms in the pharynx are causal. We determined the causes of lobar pneumonia in rural Gambia using lung aspiration. Methods Pneumonia s…
View article: The first genotype II African swine fever virus isolated in Africa provides insight into the current Eurasian pandemic
The first genotype II African swine fever virus isolated in Africa provides insight into the current Eurasian pandemic Open
African swine fever (ASF) caused by the African swine fever virus (ASFV) is ranked by OIE as the most important source of mortality in domestic pigs globally and is indigenous to African wild suids and soft ticks. Despite two ASFV genotype…
View article: Molecular epidemiology of Brucella species in mixed livestock-human ecosystems in Kenya
Molecular epidemiology of Brucella species in mixed livestock-human ecosystems in Kenya Open
Brucellosis, caused by several species of the genus Brucella , is a zoonotic disease that affects humans and animal species worldwide. Information on the Brucella species circulating in different hosts in Kenya is largely unknown, thus lim…