Eunice Lee
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View article: Single-cell analysis of temporal immune cell dynamics in alopecia areata reveals a causal role for clonally expanded CD8+ T cells in disease
Single-cell analysis of temporal immune cell dynamics in alopecia areata reveals a causal role for clonally expanded CD8+ T cells in disease Open
Alopecia areata (AA) is an immune-mediated hair loss disorder characterized by the infiltration of immune cells, including clonally expanded CD8+ T cells into lesional skin. To explore the link between CD8+ T cell clonality and disease pat…
View article: Pressure injury pain over time among nursing home residents,
Pressure injury pain over time among nursing home residents, Open
While VRS and PAINAD scores exhibited a relationship, their agreement was limited. Documentation of PrI pain on the Minimum Data Set (MDS) was found to be inadequate. Notably, 40 % of participants reported higher levels of PrI pain in the …
View article: Investigating disparities in smoking cessation treatment for veterans with multiple sclerosis: A national analysis
Investigating disparities in smoking cessation treatment for veterans with multiple sclerosis: A national analysis Open
Background and aims Smoking is a risk factor for multiple sclerosis (MS) development, symptom burden, decreased medication efficacy, and increased disease‐related mortality. Veterans with MS (VwMS) smoke at critically high rates; however, …
View article: Measurement Equivalence Test on Family Cohesion Scale: Comparison Models for White, Black, Hispanic, and Asian College or University Students in the U.S.
Measurement Equivalence Test on Family Cohesion Scale: Comparison Models for White, Black, Hispanic, and Asian College or University Students in the U.S. Open
Cohesion measure launched from the Family Adaptability and Cohesion Evaluation Scale (FACES) is a well-known instrument to assess family functioning. It is essential to perform a measurement equivalence test of cohesion targeting racially …
View article: Functional interrogation of lymphocyte subsets in alopecia areata using single-cell RNA sequencing
Functional interrogation of lymphocyte subsets in alopecia areata using single-cell RNA sequencing Open
Alopecia areata (AA) is among the most prevalent autoimmune diseases, but the development of innovative therapeutic strategies has lagged due to an incomplete understanding of the immunological underpinnings of disease. Here, we performed …
View article: Race/ethnicity-stratified fine-mapping of the MHC locus reveals genetic variants associated with late-onset asthma
Race/ethnicity-stratified fine-mapping of the MHC locus reveals genetic variants associated with late-onset asthma Open
Introduction: Asthma is a chronic disease of the airways that impairs normal breathing. The etiology of asthma is complex and involves multiple factors, including the environment and genetics, especially the distinct genetic architecture a…
View article: PS06 The beast beneath the blisters: assessment of depression and anxiety in patients with immunobullous disorders in a tertiary referral centre
PS06 The beast beneath the blisters: assessment of depression and anxiety in patients with immunobullous disorders in a tertiary referral centre Open
Immunobullous diseases can be disabling in the acute phase, causing widespread painful or pruritic skin and mucosal lesions. The subsequent psychological consequences of these disorders have not been fully evaluated. We treated a 53-year-o…
View article: Smoking Prevalence and Correlates among Chinese Immigrants: A Secondary Data Analysis Study
Smoking Prevalence and Correlates among Chinese Immigrants: A Secondary Data Analysis Study Open
Purpose: This study aimed to (1) identify the smoking prevalence among Chinese immigrants and (2) explore associations between their current smoking behaviors and demographic factors, psychological distress, and health utilization factors.…
View article: Air pollution and traffic noise interact to affect cognitive health in older Mexican Americans
Air pollution and traffic noise interact to affect cognitive health in older Mexican Americans Open
Our study indicates that PM2.5 and NO2 air pollution adversely affect cognition in elderly Mexican Americans. Our findings also suggest that air pollutants may interact with traffic-related noise exposure to affect cognitive function in vu…
View article: Questionnaire-Based Polyexposure Assessment Outperforms Polygenic Scores for Classification of Type 2 Diabetes in a Multiancestry Cohort
Questionnaire-Based Polyexposure Assessment Outperforms Polygenic Scores for Classification of Type 2 Diabetes in a Multiancestry Cohort Open
OBJECTIVE Environmental exposures may have greater predictive power for type 2 diabetes than polygenic scores (PGS). Studies examining environmental risk factors, however, have included only individuals with European ancestry, limiting the…
View article: Questionnaire-based polyexposure assessment outperforms polygenic scores for classification of type 2 diabetes in a multi-ancestry cohort
Questionnaire-based polyexposure assessment outperforms polygenic scores for classification of type 2 diabetes in a multi-ancestry cohort Open
Objective. Environmental exposures may have greater predictive power for type 2 diabetes than polygenic scores (PGS). Studies examining environmental risk factors, however, have included only individuals with European ancestry, limitin…
View article: Questionnaire-based polyexposure assessment outperforms polygenic scores for classification of type 2 diabetes in a multi-ancestry cohort
Questionnaire-based polyexposure assessment outperforms polygenic scores for classification of type 2 diabetes in a multi-ancestry cohort Open
Objective. Environmental exposures may have greater predictive power for type 2 diabetes than polygenic scores (PGS). Studies examining environmental risk factors, however, have included only individuals with European ancestry, limitin…
View article: Induction of T cell exhaustion by JAK1/3 inhibition in the treatment of alopecia areata
Induction of T cell exhaustion by JAK1/3 inhibition in the treatment of alopecia areata Open
Alopecia areata (AA) is an autoimmune disease caused by T cell-mediated destruction of the hair follicle (HF). Therefore, approaches that effectively disrupt pathogenic T cell responses are predicted to have therapeutic benefit for AA trea…
View article: A Review of the Impact of the Covid-19 Pandemic on Food Insecurity
A Review of the Impact of the Covid-19 Pandemic on Food Insecurity Open
During the COVID-19 pandemic, food insecurity increased despite legislation that put more resources into Federal Nutrition Assistance Programs. I gathered information by reviewing the literature on food insecurity during the COVID-19 pande…
View article: Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82
Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82 Open
Alopecia areata is a complex genetic disease that results in hair loss due to the autoimmune-mediated attack of the hair follicle. We previously defined a role for both rare and common variants in our earlier GWAS and linkage studies. Here…
View article: Cumulative Exposure to Neighborhood Conditions and Substance Use Initiation among Low-Income Latinx and African American Adolescents
Cumulative Exposure to Neighborhood Conditions and Substance Use Initiation among Low-Income Latinx and African American Adolescents Open
Purpose: While previous research underscores the important role that neighborhood contexts play for child and adolescent health and well-being, how these neighborhood contexts influence substance use initiation among adolescents from low-i…
View article: Cross-Cultural Instrument Adaptation and Validation of Health Beliefs About Cancer Screening
Cross-Cultural Instrument Adaptation and Validation of Health Beliefs About Cancer Screening Open
Background The uptake of cancer screening is significantly associated with participants’ health beliefs about cancer screening. Scales measuring health beliefs of cancer screening are available; however, the scales that were developed and …
View article: Ozone Exposure, Outdoor Physical Activity, and Incident Type 2 Diabetes in the SALSA Cohort of Older Mexican Americans
Ozone Exposure, Outdoor Physical Activity, and Incident Type 2 Diabetes in the SALSA Cohort of Older Mexican Americans Open
Our findings suggest that ambient exposure contributes to the development of type 2 diabetes, particularly among those with higher levels of leisure-time outdoor physical activity. Policies and strategies are needed to reduce exposure to…
View article: Trajectory of smoking behavior change among Chinese immigrant smokers
Trajectory of smoking behavior change among Chinese immigrant smokers Open
Background The incidence and mortality rates of smoking-associated lung cancer are high among Chinese immigrant smokers. Coming from a country with different smoking policies, culture, and economic background than the U.S., Chinese smokers…
View article: Native American Ancestry and Air Pollution Interact to Impact Bronchodilator Response in Puerto Rican Children with Asthma
Native American Ancestry and Air Pollution Interact to Impact Bronchodilator Response in Puerto Rican Children with Asthma Open
Objective: Asthma is the most common chronic disease in children. Short-acting bronchodilator medications are the most commonly prescribed asthma treatment worldwide, regardless of disease severity. Puerto Rican children display the highe…
View article: Associations between ambient air pollution and Alzheimer pathologic change in humans: A secondary analysis of IDEAS study data
Associations between ambient air pollution and Alzheimer pathologic change in humans: A secondary analysis of IDEAS study data Open
Background Amyloid accumulation is a defining feature of Alzheimer’s Disease (AD) and is a risk factor for cognitive decline and dementia. Previous cerebrospinal fluid and autopsy studies in humans have showed that brain β‐amyloid patholog…
View article: Metabolic dysfunction modifies the influence of traffic-related air pollution and noise exposure on late-life dementia and cognitive impairment
Metabolic dysfunction modifies the influence of traffic-related air pollution and noise exposure on late-life dementia and cognitive impairment Open
Background: Cognitive impairment has been linked to traffic-related air pollution and noise exposure as well as to metabolic syndrome or some of its individual components. Here, we investigate whether the presence of metabolic dysfunction …
View article: Association Between Ambient Air Pollution and Amyloid Positron Emission Tomography Positivity in Older Adults With Cognitive Impairment
Association Between Ambient Air Pollution and Amyloid Positron Emission Tomography Positivity in Older Adults With Cognitive Impairment Open
This study found that higher PM2.5 concentrations appeared to be associated with brain Aβ plaques. These findings suggest the need to consider airborne toxic pollutants associated with Aβ pathology in public health policy decisions and to …
View article: Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function
Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function Open
Bronchodilator (BD) drugs are commonly prescribed for treatment and management of obstructive lung function present with diseases such as asthma. Administration of BD medication can partially or fully restore lung function as measured by p…