Eunsil Hahm
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View article: [Expression of Concern] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells
[Expression of Concern] Src homology phosphotyrosyl phosphatase 2 mediates cisplatin‑related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells Open
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the immunohistochemical images shown in Figs. 1E and 5E appeared to show an overlapping section, even though Figs. 1 and 5 were inte…
View article: Type I IFN in Glomerular Disease: Scarring beyond the STING
Type I IFN in Glomerular Disease: Scarring beyond the STING Open
The field of nephrology has recently directed a considerable amount of attention towards the stimulator of interferon genes (STING) molecule since it appears to be a potent driver of chronic kidney disease (CKD). STING and its activator, t…
View article: Type I IFN in Glomerular Disease: Scarring beyond the STING
Type I IFN in Glomerular Disease: Scarring beyond the STING Open
The field of nephrology has recently directed a considerable amount of attention towards the stimulator of interferon genes (STING) molecule since it appears to be a potent driver of chronic kidney disease (CKD). STING and its activator, t…
View article: Myeloid differentiation factor-2/LY96, a potential predictive biomarker of metastasis and poor outcomes in prostate cancer: clinical implications as a potential therapeutic target
Myeloid differentiation factor-2/LY96, a potential predictive biomarker of metastasis and poor outcomes in prostate cancer: clinical implications as a potential therapeutic target Open
View article: Myeloid differentiation factor-2/LY96, a new predictive biomarker of metastasis in prostate cancer: Clinical implications as a potential therapeutic target
Myeloid differentiation factor-2/LY96, a new predictive biomarker of metastasis in prostate cancer: Clinical implications as a potential therapeutic target Open
View article: suPAR links a dysregulated immune response to tissue inflammation and sepsis-induced acute kidney injury
suPAR links a dysregulated immune response to tissue inflammation and sepsis-induced acute kidney injury Open
Acute kidney injury (AKI) secondary to sepsis results in poor outcomes and conventional kidney function indicators lack diagnostic value. Soluble urokinase plasminogen activator receptor (suPAR) is an innate immune-derived molecule implica…
View article: Bone marrow from focal segmental glomerulosclerosis displays activation of inflammatory pathway
Bone marrow from focal segmental glomerulosclerosis displays activation of inflammatory pathway Open
Circulating factors resulting from immune dysfunction have been proposed as one of the causes for increased risk of graft loss associated with recurrence of focal segmental glomerulosclerosis (FSGS) after kidney transplant. However, the pr…
View article: Identification of a Novel Aggressive CD52+ Tumor Cell Subpopulation in Metastatic Prostate Cancer
Identification of a Novel Aggressive CD52+ Tumor Cell Subpopulation in Metastatic Prostate Cancer Open
Metastasis is the primary cause of cancer-related deaths in prostate cancer (PCa) patients. The poor prognosis in metastatic PCa (mPCa) is associated with heterogeneous cell populations contributing to the disease’s progression. Unfortunat…
View article: suPAR, a Circulating Kidney Disease Factor
suPAR, a Circulating Kidney Disease Factor Open
Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation. suPAR levels have been linked to man…
View article: Guanidinylated Apolipoprotein C3 (ApoC3) Associates with Kidney and Vascular Injury
Guanidinylated Apolipoprotein C3 (ApoC3) Associates with Kidney and Vascular Injury Open
Significance Statement Posttranslational guanidinylation of ApoC3, a major constituent of triglyceride-rich lipoproteins, enhances ApoC3′s proinflammatory properties in uremia. Guanidinylated ApoC3 (gApoC3) is generated by guanidine and ur…
View article: MO451GUANIDINYLATED APOLIPOPROTEIN C3 (APOC3) A NOVEL PLAYER IN CKD AND CKD-ASSOCIATED CARDIOVASCULAR DISEASES
MO451GUANIDINYLATED APOLIPOPROTEIN C3 (APOC3) A NOVEL PLAYER IN CKD AND CKD-ASSOCIATED CARDIOVASCULAR DISEASES Open
Background and Aims Cardiovascular diseases (CVD) and chronic kidney diseases (CKD) are highly prevalent in Western populations and account for a substantial proportion of mortality. We found that apolipoprotein C-3 (ApoC3), a constituent …
View article: Nonimmune cell–derived ICOS ligand functions as a renoprotective αvβ3 integrin–selective antagonist
Nonimmune cell–derived ICOS ligand functions as a renoprotective αvβ3 integrin–selective antagonist Open
Soluble urokinase receptor (suPAR) is a circulatory molecule that activates αvβ3 integrin on podocytes, causes foot process effacement, and contributes to proteinuric kidney disease. While active integrin can be targeted by antibodies and …
View article: A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease
A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease Open
View article: Apoptosis and Compensatory Proliferation Signaling Are Coupled by CrkI-Containing Microvesicles
Apoptosis and Compensatory Proliferation Signaling Are Coupled by CrkI-Containing Microvesicles Open
View article: Extrarenal determinants of kidney filter function
Extrarenal determinants of kidney filter function Open
View article: The enhanced tumor inhibitory effects of gefitinib and L-ascorbic acid combination therapy in non-small cell lung cancer cells
The enhanced tumor inhibitory effects of gefitinib and L-ascorbic acid combination therapy in non-small cell lung cancer cells Open
Despite documentation of successful therapy with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in patients with lung cancer, the response rate of patients treated with this therapy remains low. The present study invest…
View article: Unwinding focal segmental glomerulosclerosis
Unwinding focal segmental glomerulosclerosis Open
Focal segmental glomerulosclerosis (FSGS) represents the most common primary glomerular disease responsible for the development of end-stage renal disease (ESRD) in the United States (US). The disease progresses from podocyte injury to chr…
View article: Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease Open