Eun‐Sil Park
YOU?
Author Swipe
View article: Crimean-Congo Hemorrhagic Fever Virus among Goats, Southern Bhutan
Crimean-Congo Hemorrhagic Fever Virus among Goats, Southern Bhutan Open
We conducted serosurveillance for Crimean-Congo hemorrhagic fever virus (CCHFV) among goats in southern Bhutan. Testing serum samples from 472 goats for CCHFV-specific IgG using an indirect fluorescent antibody test and ELISA, we found CCH…
View article: Bivalent single-domain antibodies show potent mpox virus neutralization through M1R antigen
Bivalent single-domain antibodies show potent mpox virus neutralization through M1R antigen Open
Despite the recent mpox outbreak raising global concerns, no fully validated antiviral treatment exists, highlighting the urgent need for effective therapeutics. Here, by taking advantage of the preparation technology for single-domain (VH…
View article: Evolutionary and structural basis of SLAMF1 utilization in morbilliviruses—Implications for host range and cross-species transmission
Evolutionary and structural basis of SLAMF1 utilization in morbilliviruses—Implications for host range and cross-species transmission Open
Morbilliviruses, including measles virus (MV), canine distemper virus (CDV), peste des petits ruminants virus, and cetacean morbillivirus pose a significant threat to humans and animals. While the host range of morbilliviruses is generally…
View article: Comparison of the induction of neutralizing antibodies against Bas congo virus using several vaccine modalities
Comparison of the induction of neutralizing antibodies against Bas congo virus using several vaccine modalities Open
The Bas-Congo virus (BASV) is a novel rhabdovirus that causes viral hemorrhagic fever in 2009. Since BASV has not been isolated, there is limited information on BASV, and potential therapeutics or vaccines have not yet been developed. In t…
View article: Oz Virus Infection in 6 Animal Species, Including Macaques, Bears, and Companion Animals, Japan
Oz Virus Infection in 6 Animal Species, Including Macaques, Bears, and Companion Animals, Japan Open
Oz virus (OZV) was isolated from an Amblyomma tick in Japan and shown to cause lethal viral myocarditis in humans. However, the natural reservoirs and the distribution of OZV remain unknown. We describe epidemiologic studies conducted by u…
View article: Evolutionary and structural basis of SLAM utilization in morbilliviruses – Its implications for host range and cross-species transmission
Evolutionary and structural basis of SLAM utilization in morbilliviruses – Its implications for host range and cross-species transmission Open
Morbilliviruses, including measles virus (MV), canine distemper virus (CDV), and cetacean morbillivirus, pose a significant threat to humans and animals. While the host range of morbilliviruses is generally well-defined, severe cross-speci…
View article: Transboundary Movement of Yezo Virus via Ticks on Migratory Birds, Japan, 2020–2021
Transboundary Movement of Yezo Virus via Ticks on Migratory Birds, Japan, 2020–2021 Open
Migratory birds carry ticks harboring various pathogens, including the zoonotic Yezo virus. In Hokkaido, Japan, we collected ticks from migratory birds during 2020-2021. Eight of 385 pools, comprising 2,534 ticks, tested positive for Yezo …
View article: The comparison of pathogenicity among SARS-CoV-2 variants in domestic cats
The comparison of pathogenicity among SARS-CoV-2 variants in domestic cats Open
View article: Surveillance of SARS-CoV-2 Infection in Rodent Populations in Tokyo, Japan
Surveillance of SARS-CoV-2 Infection in Rodent Populations in Tokyo, Japan Open
The persistence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among wildlife populations poses a potential risk for the emergence of novel variants. Therefore, monitoring SARS-CoV-2 infections in animals is crucial. As ur…
View article: Characterization of human tibrovirus envelope glycoproteins
Characterization of human tibrovirus envelope glycoproteins Open
Tibroviruses are novel rhabdoviruses detected in humans, cattle, and arthropods. Four tibroviruses are known to infect humans: Bas-Congo virus (BASV), Ekpoma virus 1 (EKV-1), Ekpoma virus 2, and Mundri virus. However, since none of them ha…
View article: Stability of Bas-Congo virus neutralising antibodies in serum samples during long-term storage—Authors’ reply
Stability of Bas-Congo virus neutralising antibodies in serum samples during long-term storage—Authors’ reply Open
We thank Lifeng Zhao and colleagues for raising potential issues in our Article1Munyeku-Bazitama Y Okitale-Talunda P Hattori T et al.Seroprevalence of Bas-Congo virus in Mangala, Democratic Republic of the Congo: a population-based cross-s…
View article: Construction of Vero cell-adapted rabies vaccine strain by five amino acid substitutions in HEP-Flury strain
Construction of Vero cell-adapted rabies vaccine strain by five amino acid substitutions in HEP-Flury strain Open
Rabies virus (RABV) causes fatal neurological disease. Pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) using inactivated-virus vaccines are the most effective measures to prevent rabies. In Japan, HEP-Flury, the viral s…
View article: Draft genome sequence of <i>Yersinia pseudotuberculosis</i> isolated from a wild rat in Japan
Draft genome sequence of <i>Yersinia pseudotuberculosis</i> isolated from a wild rat in Japan Open
We report a draft genome sequence of Yersinia pseudotuberculosis isolated from the spleen of a wild rat from Mikura-shima Island, Japan. The bacterium was identified as serotype O:4b using PCR-based O-genotyping. These genomic data provide…
View article: Seroprevalence of Bas-Congo virus in Mangala, Democratic Republic of the Congo: a population-based cross-sectional study
Seroprevalence of Bas-Congo virus in Mangala, Democratic Republic of the Congo: a population-based cross-sectional study Open
Japan Agency for Medical Research and Development (AMED) and Japan International Cooperation Agency (JICA) under the Science and Technology Research Partnership for Sustainable Development (SATREPS) and Japan Program for Infectious Disease…
View article: Interplay of IGF1R and estrogen signaling regulates hematopoietic stem and progenitor cells
Interplay of IGF1R and estrogen signaling regulates hematopoietic stem and progenitor cells Open
Tissue stem cells often exhibit developmental stage-specific and sexually dimorphic properties, but the underlying mechanism remains largely elusive. By characterizing IGF1R signaling in hematopoietic cells, here we report that its disrupt…
View article: Lethal severe fever with thrombocytopenia syndrome virus infection causes systemic germinal centre failure and massive T cell apoptosis in cats
Lethal severe fever with thrombocytopenia syndrome virus infection causes systemic germinal centre failure and massive T cell apoptosis in cats Open
Introduction Severe fever with thrombocytopenia syndrome (SFTS) is a fatal viral disease characterized by high fever, thrombocytopenia, leukopenia, and multi-organ haemorrhage. Disruption of the humoral immune response and decreased lympho…
View article: Establishment of serological neutralizing tests using pseudotyped viruses for comprehensive detection of antibodies against all 18 lyssaviruses
Establishment of serological neutralizing tests using pseudotyped viruses for comprehensive detection of antibodies against all 18 lyssaviruses Open
Rabies is a fatal zoonotic, neurological disease caused by rabies lyssavirus (RABV) and other lyssaviruses. In this study, we established novel serological neutralizing tests (NT) based on vesicular stomatitis virus pseudotypes possessing …
View article: High Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus Infection among the Dog Population in Thailand
High Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus Infection among the Dog Population in Thailand Open
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonotic disease caused by the SFTS virus (SFTSV). In Thailand, three human cases of SFTS were reported in 2019 and 2020, but there was no report of SFTSV infecti…
View article: Pet Animals Were Infected with SARS-CoV-2 from Their Owners Who Developed COVID-19: Case Series Study
Pet Animals Were Infected with SARS-CoV-2 from Their Owners Who Developed COVID-19: Case Series Study Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among pets owned by coronavirus disease 2019 (COVID-19) patients has been reported around the world. However, how often the animals are exposed to SARS-CoV-2 by their o…
View article: Identification of IMP Dehydrogenase as a Potential Target for Anti-Mpox Virus Agents
Identification of IMP Dehydrogenase as a Potential Target for Anti-Mpox Virus Agents Open
Mpox is a zoonotic disease caused by infection with the mpox virus, and a worldwide outbreak occurred in May 2022. The smallpox vaccine has recently been approved for clinical use against mpox in the United States.
View article: Potential Anti-Mpox Virus Activity of Atovaquone, Mefloquine, and Molnupiravir, and Their Potential Use as Treatments
Potential Anti-Mpox Virus Activity of Atovaquone, Mefloquine, and Molnupiravir, and Their Potential Use as Treatments Open
Background Mpox virus (MPXV) is a zoonotic orthopoxvirus and caused an outbreak in 2022. Although tecovirimat and brincidofovir are approved as anti-smallpox drugs, their effects in mpox patients have not been well documented. In this stud…
View article: Identification of inosine monophosphate dehydrogenase as a potential target for anti-monkeypox virus agents
Identification of inosine monophosphate dehydrogenase as a potential target for anti-monkeypox virus agents Open
Monkeypox virus (MPXV) is a neglected zoonotic pathogen that caused a worldwide outbreak in May 2022. Given the lack of an established therapy, the development of an anti-MPXV strategy is of vital importance. To identify drug targets for t…
View article: Distinct niche structures and intrinsic programs of fallopian tube and ovarian surface epithelial cells
Distinct niche structures and intrinsic programs of fallopian tube and ovarian surface epithelial cells Open
View article: Lethal Disease in Dogs Naturally Infected with Severe Fever with Thrombocytopenia Syndrome Virus
Lethal Disease in Dogs Naturally Infected with Severe Fever with Thrombocytopenia Syndrome Virus Open
Severe fever with the thrombocytopenia syndrome virus (SFTSV) causes fatal disease in humans, cats, and cheetahs. In this study, the information on seven dogs with SFTS was summarized. All dogs showed anorexia, high fever, leukopenia, and …
View article: Potential anti-monkeypox virus activity of atovaquone, mefloquine, and molnupiravir, and their potential use as treatments
Potential anti-monkeypox virus activity of atovaquone, mefloquine, and molnupiravir, and their potential use as treatments Open
Monkeypox virus (MPXV) is a zoonotic orthopoxvirus that causes smallpox-like symptoms in humans and caused an outbreak in May 2022 that led the WHO to declare global health emergency. In this study, from a screening of approved-drug librar…
View article: Reverse Genetics System for Heartland Bandavirus: NSs Protein Contributes to Heartland Bandavirus Virulence
Reverse Genetics System for Heartland Bandavirus: NSs Protein Contributes to Heartland Bandavirus Virulence Open
Heartland bandavirus (HRTV) is a tick-borne virus identified in the United States in 2009. HRTV causes fever, fatigue, decreased appetite, headache, nausea, diarrhea, and muscle or joint pain in humans.
View article: Vaccination-infection interval determines cross-neutralization potency to SARS-CoV-2 Omicron after breakthrough infection by other variants
Vaccination-infection interval determines cross-neutralization potency to SARS-CoV-2 Omicron after breakthrough infection by other variants Open
View article: Oncogenic Events Dictate the Types and Locations of Gynecological Malignancies Originating from Krt8+ Mesothelial and Müllerian-Derived Epithelial Cells
Oncogenic Events Dictate the Types and Locations of Gynecological Malignancies Originating from Krt8+ Mesothelial and Müllerian-Derived Epithelial Cells Open
Ovarian and uterine cancers are the most prevalent types of gynecological malignancies originating from mesothelial and/or Müllerian-derived epithelial cells. Recent genomic studies have identified common mutations in them that affect sign…
View article: Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8+ T cell responses
Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8+ T cell responses Open
View article: Roles of raccoons in the transmission cycle of severe fever with thrombocytopenia syndrome virus
Roles of raccoons in the transmission cycle of severe fever with thrombocytopenia syndrome virus Open
The present study investigated severe fever with thrombocytopenia syndrome virus (SFTSV) infection in raccoons in Wakayama Prefecture from 2007 to 2019. To perform surveillance, an enzyme-linked immunosorbent assay (ELISA) was established,…