Eusra Mohammad
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View article: CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release
CDK7 kinase activity promotes RNA polymerase II promoter escape by facilitating initiation factor release Open
Cyclin-dependent kinase 7 (CDK7), part of the general transcription factor TFIIH, promotes gene transcription by phosphorylating the C-terminal domain of RNA polymerase II (RNA Pol II). Here, we combine rapid CDK7 kinase inhibition with mu…
Bioinformatic analysis of multi-omics data elucidates transcriptional cyclin dependent kinase mediated transcriptional regulation Open
Transcriptional regulation is a highly dynamic biological process which is governed by a complex network of proteins for precise expression of a gene. One of the most important regulators of gene expression are cyclin dependent kinases (CD…
View article: CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation
CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation Open
Cyclin-dependent kinase 12 (CDK12) phosphorylates the carboxyl-terminal domain (CTD) of RNA polymerase II (pol II) but its roles in transcription beyond the expression of DNA damage response genes remain unclear. Here, we have used TT-seq …
Additional file 5 of Aberration of the modulatory functions of intronic microRNA hsa-miR-933 on its host gene ATF2 results in type II diabetes mellitus and neurodegenerative disease development Open
Additional file 5: Contingency table of the Chi-square test for finding the statistical significance of the overlapped targets of miR-933 and ATF2.
View article: The Implication of Early Chromatin Changes in X Chromosome Inactivation
The Implication of Early Chromatin Changes in X Chromosome Inactivation Open
During development, the precise relationships between transcription and chromatin modifications often remain unclear. We use the X chromosome inactivation (XCI) paradigm to explore the implication of chromatin changes in gene silencing. Us…