Eva Bezak
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Modelling the impact of tumour hypoxia on proton therapy and concurrent chemotherapy on locally advanced pancreatic cancer—insights from an <i>in silico</i> study Open
Objective. Pancreatic adenocarcinoma (PDAC) is notoriously difficult to treat due to treatment-resistance and the pancreas’ proximity to organs at risks (OARs). Tumour hypoxia further complicates treatment, with substantial intra- and inte…
Antenatal Point‐of‐Care Ultrasound Training and Accreditation: A Cross‐Sectional Survey of Australian Rural Clinicians Open
Objective To explore the perceptions of rural Australian clinicians towards antenatal point‐of‐care ultrasound (APoCUS) training and accreditation, investigating barriers and enablers to continuing professional development (CPD). Methods A…
Development and Evaluation of an Electronic Patient‐Reported Outcome Platform for Children Undergoing Radiation Therapy Open
Introduction Health‐related quality of life (HRQoL) outcomes are not routinely collected in paediatric radiation therapy (RT). This study co‐designed and evaluated an electronic platform to support routine HRQoL assessment using patient‐re…
Impact of substructure radiation dose on health-related quality of life in children with brain tumors: a Pediatric Proton/Photon Consortium Registry (PPCR) study Open
Purpose Cranial irradiation is associated with health-related quality of life (HRQoL) deficits in childhood cancer survivors. We investigated the relationship between radiation dose to brain substructures and HRQoL in children with brain t…
Mechanisms of ATM Inhibitor AZD1390-Mediated Radiosensitization by Comparing DNA DSB Formation and Repair in 4T1 Cells Open
Radioresistant cancers often exhibit upregulated DNA damage response (DDR) proteins including ataxia telangiectasia mutated (ATM), recovering more readily from radiation-induced DNA double-strand breaks (DSBs). ATM inhibitors (ATMi) are th…
Observer Variability in CT Angiography Carotid Segmentation: Assessing Variability to Set Minimum Clinical Performance Open
Background and Purpose This work evaluates carotid atherosclerosis quantification from computed tomography angiography (CTA), by novice and expert human contours. Variability sources are critically assessed to establish the minimum perform…
Healthcare Professional Perspectives on Digital Health‐Related Quality‐of‐Life Assessment in Paediatric Radiation Therapy: A Qualitative Study Open
Introduction Health‐related quality of life (HRQoL) is not routinely evaluated using patient‐reported outcome measures (PROMs) in paediatric radiation therapy (RT). This study aimed to identify barriers and facilitators to HRQoL implementa…
Small-scale bone marrow dosimetry study for 225Ac Open
Our model demonstrated a non-uniform absorbed dose profile to the red marrow due to alpha emissions on the trabecular bone surface. The alpha emissions irradiated less than half of the marrow voxels,while the beta emissions irradiated all …
View article: 3D printed microtissue cassettes enabling high throughput proton radiobiological assays
3D printed microtissue cassettes enabling high throughput proton radiobiological assays Open
The results validate the reliability of the 3D printed cassette in addressing critical radiobiological issues. This methodology enables high throughput irradiation workflow and consequently reduce the time and resource burden for clinical …
Ultrasound of the uterosacral ligaments: A reliability study for diagnosing endometriosis in Australian non‐specialised medical imaging and radiology settings Open
Introduction/Background Uterosacral ligaments (USL) are the most common sites of endometriosis. Transvaginal ultrasound (TVS) demonstrates high diagnostic accuracy for endometriosis of the USLs using standardised technique and characterisa…
View article: A gender breakdown of unexpected benefits generated by work from home in STEM fields − A qualitative analysis of the WiMPBME Task Group survey
A gender breakdown of unexpected benefits generated by work from home in STEM fields − A qualitative analysis of the WiMPBME Task Group survey Open
The findings of the survey show the diversity of perceptions about remote working in STEM fields, while highlighting the importance of considering family dynamics, individual circumstances as well as gender when evaluating varied experienc…
Relationship Between Ultrasound Diagnosis, Symptoms and Pain Scale Score on Examination in Patients with Uterosacral Ligament Endometriosis Open
Background/Objectives: This study investigated patient pain descriptors for transvaginal ultrasound (TVS) diagnostic evaluation of endometriosis for uterosacral ligaments (USLs), including correlation between USL thickness and site-specifi…
Hyperparameter selection for dataset‐constrained semantic segmentation: Practical machine learning optimization Open
Purpose/aim This paper provides a pedagogical example for systematic machine learning optimization in small dataset image segmentation, emphasizing hyperparameter selections. A simple process is presented for medical physicists to examine …
View article: 3D printed microtissue cassettes enabling high throughput proton radiobiological assays
3D printed microtissue cassettes enabling high throughput proton radiobiological assays Open
Uncertainties on proton relative biological effectiveness (RBE) across the spread out of Bragg peak (SOBP) (typically assumed to be 1.1) may lead to suboptimal treatment plan and unwarranted toxicity to organs-at-risk. Herein, we report a …
Exercise positively impacts global longitudinal strain in women at risk of developing cardiovascular disease Open
Cardiovascular (CV) disease accounts for one third of deaths in females, with hypertension (HTN) and type 2 diabetes mellitus (T2DM) risk factors for its development. Global longitudinal strain (GLS) is a strong prognostic indicator for fu…
Sonographer wellbeing in Australia: Perceptions of job demands and resources in clinical working environments Open
Introduction The concept that job characteristics can have a profound impact on employee wellbeing has been well documented. This manuscript aims to highlight the job demands and resources experienced by Australian sonographers, and those …
DNA Double Strand Break and Response Fluorescent Assays: Choices and Interpretation Open
Accurately characterizing DNA double-stranded breaks (DSBs) and understanding the DNA damage response (DDR) is crucial for assessing cellular genotoxicity, maintaining genomic integrity, and advancing gene editing technologies. Immunofluor…
Modeling the effect of daughter migration on dosimetry estimates for unlabeled actinium‐225 Open
Background Actinium‐225 ( 225 Ac) is an alpha emitting radionuclide which has demonstrated promising results in Targeted Alpha Therapy (TAT). A concern with 225 Ac is that the decay energy can break the bond to the targeting vehicle, resul…
Opportunities in Cancer Therapies: Deciphering the Role of Cancer Stem Cells in Tumour Repopulation Open
Tumour repopulation during treatment is a well acknowledged yet still challenging aspect of cancer management. The latest research results show clear evidence towards the existence of cancer stem cells (CSCs) that are responsible for tumou…
Antenatal ultrasound needs-analysis survey of Australian rural/remote healthcare clinicians: recommendations for improved service quality and access Open
Background Ultrasound is the primary diagnostic tool in pregnancy, capable of identifying high-risk pregnancies and life-threatening conditions, allowing for appropriate management to prevent maternal and fetal morbidity and mortality. Wom…
Simple quantitative planimetric measurement of nigrosome-1 for clinical settings Open
The simple quantitative method, used with subjectively rated nigrosome-1 appearance, may improve confidence in longitudinal clinical reporting, when nigrosome-1 is attenuated. However, further work on the incremental diagnostic value of pl…
How do practitioners prescribe exercise to patients with breast cancer? Professional perspectives on the key considerations for aerobic exercise in patients with breast cancer undergoing chemotherapy Open
This study identifies how professionals approach exercise assessment and prescription in patients with breast cancer undergoing chemotherapy. Findings can guide AEPs in practice when prescribing tailored exercise to breast cancer patients …
Modelling the influence of radiosensitivity on development of second primary cancer in out-of-field organs following proton therapy for paediatric cranial cancer Open
Objective: Radiobiological modelling the risks of second primary cancer (SPC) after proton therapy (PT) for childhood cranial cancer remains largely unknown. Organ-specific dose-response risk factors such as radiosensitivity require explor…
Global status of medical physics human resource – The IOMP survey report Open
There are new findings on number of MPs per million population in different countries, with some expressing adequacy in the total number of MPs, but the data breakdown indicates a shortage in diagnostic X-ray physicists. Future surveys sho…
A Systematic Review of LET-Guided Treatment Plan Optimisation in Proton Therapy: Identifying the Current State and Future Needs Open
The well-known clinical benefits of proton therapy are achieved through higher target-conformality and normal tissue sparing than conventional radiotherapy. However, there is an increased sensitivity to uncertainties in patient motion/setu…
In vitro characterisation of [177Lu]Lu-DOTA-C595 as a novel radioimmunotherapy for MUC1-CE positive pancreatic cancer Open
Background Pancreatic ductal adenocarcinoma (PDAC) continues to be a malignancy with an unmet clinical demand. Development of radioimmunoconjugates which target cancer-specific receptors provides an opportunity for radioimmunotherapy of bo…