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View article: Proteomic profiling of primary cilia in the developing brain uncovers new regulators of cortical development
Proteomic profiling of primary cilia in the developing brain uncovers new regulators of cortical development Open
In the developing brain, the primary cilia of radial glial cells extend from the surface of the lateral ventricle, serving as the signaling hub to integrate environmental cues critical for brain formation. Dysfunctions in ciliary proteins …
View article: Proximity based proteomics reveals Git1 as a regulator of Smoothened signaling
Proximity based proteomics reveals Git1 as a regulator of Smoothened signaling Open
The GPCR-like protein Smoothened (Smo) plays a pivotal role in the Hedgehog (Hh) pathway. To initiate Hh signaling, active Smo binds to and inhibits the catalytic subunit of PKA in the primary cilium, a process facilitated by G protein-cou…
View article: Hedgehog Signaling in Cortical Development
Hedgehog Signaling in Cortical Development Open
The Hedgehog (Hh) pathway plays a crucial role in embryonic development, acting both as a morphogenic signal that organizes tissue formation and a potent mitogenic signal driving cell proliferation. Dysregulated Hh signaling leads to vario…
View article: Cilium proteomics reveals Numb as a positive regulator of the Hedgehog signaling pathway
Cilium proteomics reveals Numb as a positive regulator of the Hedgehog signaling pathway Open
SUMMARY The transduction of Hedgehog (Hh) signaling relies on the primary cilium, a cell surface organelle serving as a signaling hub for the cell. Using proximity labeling and quantitative proteomics, we identified Numb as a new ciliary p…