David L. Adelson
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Structures of vertebrate R2 retrotransposon complexes during target-primed reverse transcription and after second-strand nicking Open
R2 retrotransposons are site-specific eukaryotic non–long terminal repeat retrotransposons that copy and paste into gene loci encoding ribosomal RNAs. Recently, we demonstrated that avian A-clade R2 proteins achieve efficient and precise i…
Lineage-Specific Evolution, Structural Diversity, and Activity of R2 Retrotransposons in Animals Open
Retrotransposons play outsized roles in the evolution of gene regulation, genome function, and disease pathogenesis and more recently, have sparked interest as workhorses for new gene therapy approaches. R2 retrotransposons insert site-spe…
Cattle T2T X Chromosome: Insights into Natural Neocentromere Evolution Open
The cattle genome is crucial for understanding ruminant biology, but it remains incomplete. The first telomere-to-telomere haplotype-resolved X chromosome and four autosomes of cattle are presented in a near-complete assembly that is 431 M…
A novel sensitizer reduces EGFR-TKI resistance by regulating the PI3K/Akt/mTOR pathway and autophagy Open
YFSJ reduced the viability of EGFR-TKI-resistant cell lines, reducing resistance to gefitinib. This might be caused by a decrease in the PI3K/Akt/mTOR pathway and an increase in autophagy.
Structures of vertebrate R2 retrotransposon complexes during target-primed reverse transcription and after second strand nicking Open
R2 retrotransposons are model site-specific eukaryotic non-LTR retrotransposons that copy-and-paste into gene loci encoding ribosomal RNAs. Recently we demonstrated that avian A-clade R2 proteins achieve efficient and precise insertion of …
An unmet need for pharmacology: Treatments for radiation-induced gastrointestinal mucositis Open
Gastrointestinal mucositis (GIM) continues to be a significant issue in the management of abdominal cancer radiation treatments and chemotherapy, causing significant patient discomfort and therapy interruption or even cessation. This revie…
Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowth Open
Germline epigenetic programming, including genomic imprinting, substantially influences offspring development. Polycomb Repressive Complex 2 (PRC2) plays an important role in Histone 3 Lysine 27 trimethylation (H3K27me3)-dependent imprinti…
Validating the Target Functions and Synergistic Multi-Target, Multi-Pathway Action Mode of Compound Kushen Injection Using CRISPR/CAS Open
Background and Purpose Due to the complexity of traditional Chinese medicine based on complex mixtures of natural products and their multi-target mechanism of action, the discovery and validation of relevant targets have always been challe…
View article: AMHY and sex determination in egg-laying mammals
AMHY and sex determination in egg-laying mammals Open
The sex chromosomes of egg-laying mammals (monotremes), which lack the sex determining gene SRY, evolved independently to those of all therian mammals. Here we characterise the candidate monotreme sex determining gene, the Y-localised anti…
Multiple horizontal transfer events of a DNA transposon into turtles, fishes, and a frog Open
Horizontal transfer of transposable elements (HTT) has been reported across many species and the impact of such events on genome structure and function has been well described. However, few studies have focused on reptilian genomes, especi…
Differential allelic representation (DAR) identifies candidate eQTLs and improves transcriptome analysis Open
In comparisons between mutant and wild-type genotypes, transcriptome analysis can reveal the direct impacts of a mutation, together with the homeostatic responses of the biological system. Recent studies have highlighted that, when the eff…
View article: RT2T: A Global Collaborative Project to Study Chromosomal Evolution in the Suborder Ruminantia
RT2T: A Global Collaborative Project to Study Chromosomal Evolution in the Suborder Ruminantia Open
The publication of the first complete, haploid telomere-to-telomere (T2T) human genome revealed new insights into the structure and function of the heretofore “invisible” parts of the genome including centromeres, tandem repeat arrays, and…
View article: RT2T: A Global Collaborative Project to Study Chromosomal Evolution in the Suborder Ruminantia
RT2T: A Global Collaborative Project to Study Chromosomal Evolution in the Suborder Ruminantia Open
The publication of the first complete, haploid telomere-to-telomere (T2T) human genome revealed new insights into the structure and function of the heretofore “invisible” parts of the genome including centromeres, tandem repeat arrays, and…
An unmet need for pharmacology: treatments for radiation induced gastrointestinal mucositis. Open
Gastrointestinal mucositis (GIM) continues to be a significant issue in the management of abdominal cancer radiation treatments and chemotherapy, causing significant patient discomfort and therapy interruption or even cessation. This revie…
Fake IDs? Widespread misannotation of DNA transposons as a general transcription factor Open
Accurate annotation of genes and transposable elements (TEs) is vital for understanding genomes, but current annotation pipelines often misannotate TEs as genes. This study reveals how the general transcription factor II-I repeat domain-co…
Jumping between Turtles, Fishes, and a Frog: The Unexpected Horizontal Transfer of a DNA Transposon Open
Horizontal transfer of transposable elements (HTT) has been reported across many species and the impact of such events on genome structure and function has been well described. However, few studies have focused on reptilian genomes, especi…
The genome of medicinal plant<i>Sophora flavescens</i>has undergone significant expansion of both transposons and genes Open
Purpose Sophora flavescens is a medicinal plant in the genus Sophora of the Fabaceae family. The root of S. flavescens is known in China as Kushen and has a long history of wide use in multiple formulations of Traditional Chinese Medicine …
Dataset for the genome of medicinal plant Sophora flavescens has undergone significant expansion of both transposons and genes Open
Sophora flavescens is a medicinal plant in the genus Sophora of the Fabaceae family. The root of S. flavescens is known in China as Kushen and has a long history of wide use in multiple formulations of Traditional Chinese Medicine (TCM). H…
Dataset for the genome of medicinal plant Sophora flavescens has undergone significant expansion of both transposons and genes Open
Sophora flavescens is a medicinal plant in the genus Sophora of the Fabaceae family. The root of S. flavescens is known in China as Kushen and has a long history of wide use in multiple formulations of Traditional Chinese Medicine (TCM). H…
Dataset for the genome of medicinal plant Sophora flavescens has undergone significant expansion of both transposons and genes Open
Sophora flavescens is a medicinal plant in the genus Sophora of the Fabaceae family. The root of S. flavescens is known in China as Kushen and has a long history of wide use in multiple formulations of Traditional Chinese Medicine (TCM). H…
Differential allelic representation (DAR) identifies candidate eQTLs and improves transcriptome analysis Open
In comparisons between mutant and wild-type genotypes, transcriptome analysis can reveal the direct impacts of a mutation, together with the homeostatic responses of the biological system. Recent studies have highlighted that, when homozyg…