Eva d’Hennezel
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View article: Targeted degradation of IKZF2 for cancer immunotherapy
Targeted degradation of IKZF2 for cancer immunotherapy Open
Growing malignant tumors must evade destruction by the immune system, a hurdle some malignancies overcome by attracting immune-suppressive regulatory T-cells (Tregs)1. The IKZF2 (Helios) transcription factor plays a crucial role in maintai…
View article: Signaling Through gp130 Compromises Suppressive Function in Human FOXP3+ Regulatory T Cells
Signaling Through gp130 Compromises Suppressive Function in Human FOXP3+ Regulatory T Cells Open
The CD4+FOXP3+ regulatory T cell (Treg) subset is an indispensable mediator of immune tolerance. While high and stable expression of the transcription factor FOXP3 is considered a hallmark feature of Treg cells, our previous studies have d…
View article: Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling
Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling Open
While the ability for humans to host a complex microbial ecosystem is an essential property of life, the mechanisms allowing for immune tolerance of such a large microbial load are not completely understood and are currently the focus of i…
View article: Coexpression of TIGIT and FCRL3 Identifies Helios+ Human Memory Regulatory T Cells
Coexpression of TIGIT and FCRL3 Identifies Helios+ Human Memory Regulatory T Cells Open
Two distinct subsets of CD4+Foxp3+ regulatory T (Treg) cells have been described based on the differential expression of Helios, a transcription factor of the Ikaros family. Efforts to understand the origin and biological roles of these Tr…