Eva Faurobert
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View article: Junctional adhesion molecule C limits glioblastoma stem-like cell invasion by regulating integrin adhesion at the endothelial interface
Junctional adhesion molecule C limits glioblastoma stem-like cell invasion by regulating integrin adhesion at the endothelial interface Open
While locating in different microenvironments, glioblastoma stem-like cells (GSCs) receive maintenance signals and information to exploit neurovascular tracts. Although the cell adhesion mechanisms to blood vessels have been explored, the …
View article: Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations
Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations Open
View article: Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth
Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth Open
View article: The Junctional Adhesion Molecule C (JAMC) Determines the Invasive Properties of Glioblastoma Stem-Like Cells at the Endothelial Interface
The Junctional Adhesion Molecule C (JAMC) Determines the Invasive Properties of Glioblastoma Stem-Like Cells at the Endothelial Interface Open
View article: Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth
Force-mediated recruitment and reprogramming of healthy endothelial cells drive vascular lesion growth Open
Force-driven cellular interactions are known to play a critical role in cancer cell invasion, but have remained largely unexplored in the context of vascular abnormalities, partly due to a lack of suitable genetic and cellular models. One …
View article: Correction to: VEGF165b, a splice variant of VEGF-A, promotes lung tumor progression and escape from anti-angiogenic therapies through a β1 integrin/VEGFR autocrine loop
Correction to: VEGF165b, a splice variant of VEGF-A, promotes lung tumor progression and escape from anti-angiogenic therapies through a β1 integrin/VEGFR autocrine loop Open
View article: Novel, non-conventional pathways of necroptosis in the heart and other organs: Molecular mechanisms, regulation and inter-organelle interplay
Novel, non-conventional pathways of necroptosis in the heart and other organs: Molecular mechanisms, regulation and inter-organelle interplay Open
View article: Impaired retinoic acid signaling in cerebral cavernous malformations
Impaired retinoic acid signaling in cerebral cavernous malformations Open
View article: β1 integrin monoclonal antibody treatment ameliorates cerebral cavernous malformations
β1 integrin monoclonal antibody treatment ameliorates cerebral cavernous malformations Open
β1 integrins are important in blood vessel formation and function, finely tuning the adhesion of endothelial cells to each other and to the extracellular matrix. The role of integrins in the vascular disease, cerebral cavernous malformatio…
View article: CCM2-deficient endothelial cells undergo a ROCK-dependent reprogramming into senescence-associated secretory phenotype
CCM2-deficient endothelial cells undergo a ROCK-dependent reprogramming into senescence-associated secretory phenotype Open
View article: Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch
Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch Open
Mechanical forces are key stimuli that dynamically adjust vessel distribution and diameter, but the precise mechanisms of force adaptation are unclear. This study identifies a biphasic response to cyclic stretch, consisting of an initial c…
View article: CCM2 deficient endothelial cells undergo a mechano-dependent reprogramming into senescence associated secretory phenotype used to recruit endothelial and immune cells
CCM2 deficient endothelial cells undergo a mechano-dependent reprogramming into senescence associated secretory phenotype used to recruit endothelial and immune cells Open
Cerebral Cavernous Malformations (CCM) is a cerebrovascular disease in which stacks of dilated haemorrhagic capillaries form focally in the brain. Whether and how defective mechanotransduction, cellular mosaicism and inflammation interplay…
View article: CC17 group B Streptococcus exploits integrins for neonatal meningitis development
CC17 group B Streptococcus exploits integrins for neonatal meningitis development Open
Group B Streptococcus (GBS) is the major cause of human neonatal infections. A single clone, designated CC17-GBS, accounts for more than 80% of meningitis cases, the most severe form of the infection. However, the events allowing blood-bor…
View article: Control of SRC molecular dynamics encodes distinct cytoskeletal responses by specifying signaling pathway usage
Control of SRC molecular dynamics encodes distinct cytoskeletal responses by specifying signaling pathway usage Open
Upon activation by different transmembrane receptors, the same signaling protein can induce distinct cellular responses. A way to decipher the mechanisms of such pleiotropic signaling activity is to directly manipulate the decision-making …
View article: Molecular flux control encodes distinct cytoskeletal responses by specifying SRC signaling pathway usage
Molecular flux control encodes distinct cytoskeletal responses by specifying SRC signaling pathway usage Open
Multi-domain signaling proteins sample numerous stimuli to coordinate distinct cellular responses. Understanding the mechanisms of their pleiotropic signaling activity requires to directly manipulate their activity of decision leading to d…
View article: VEGF165b, a splice variant of VEGF-A, promotes lung tumor progression and escape from anti-angiogenic therapies through a β1 integrin/VEGFR autocrine loop
VEGF165b, a splice variant of VEGF-A, promotes lung tumor progression and escape from anti-angiogenic therapies through a β1 integrin/VEGFR autocrine loop Open
View article: Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations
Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations Open
View article: Interrogating the ccm-3 Gene Network
Interrogating the ccm-3 Gene Network Open
Cerebral cavernous malformations (CCMs) are neurovascular lesions caused by mutations in one of three genes (CCM1-3). Loss of CCM3 causes the poorest prognosis, and little is known about how it regulates vascular integrity. The C. elegans …
View article: The CCM1–CCM2 complex controls complementary functions of ROCK1 and ROCK2 that are required for endothelial integrity
The CCM1–CCM2 complex controls complementary functions of ROCK1 and ROCK2 that are required for endothelial integrity Open
Endothelial integrity relies on a mechanical crosstalk between intercellular and cell–matrix interactions. This crosstalk is compromised in hemorrhagic vascular lesions of patients carrying loss-of-function mutations in cerebral cavernous …
View article: Correction: ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2–MRCKα balance
Correction: ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2–MRCKα balance Open
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View article: ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2–MRCKα balance
ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2–MRCKα balance Open
Cell migration is a complex process requiring density and rigidity sensing of the microenvironment to adapt cell migratory speed through focal adhesion and actin cytoskeleton regulation. ICAP-1 (also known as ITGB1BP1), a β1 integrin partn…
View article: Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes
Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes Open
Invadosomes are acto-adhesive structures able to both bind the extracellular matrix (ECM) and digest it. Paxillin family members—paxillin, Hic-5, and leupaxin—are implicated in mechanosensing and turnover of adhesion sites, but the contrib…
View article: β3 integrin–mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner
β3 integrin–mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner Open
Understanding how cells integrate multiple signaling pathways to achieve specific cell differentiation is a challenging question in cell biology. We have explored the physiological presentation of BMP-2 by using a biomaterial that harbors …
View article: Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins.
Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins. Open
Mechanotransduction pathways are activated in response to biophysical stimuli during the development or homeostasis of organs and tissues. In zebrafish, the blood-flow-sensitive transcription factor Klf2a promotes VEGF-dependent angiogenes…
View article: Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins
Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins Open