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View article: Estimates of Urinary Calcium Excretion in Dogs With and Without Calcium Oxalate Urolithiasis
Estimates of Urinary Calcium Excretion in Dogs With and Without Calcium Oxalate Urolithiasis Open
Background Fractional excretion of calcium (FeCa) and urine calcium‐to‐creatinine ratios (UCaCr) estimate hypercalciuria, but more data are needed on how well they discriminate between dogs with and without CaOx urolithiasis. Objective To …
View article: Differential gene expression analysis in French bulldog high grade oligodendroglioma: breed-associated differences in tumor and tumor microenvironment gene expression
Differential gene expression analysis in French bulldog high grade oligodendroglioma: breed-associated differences in tumor and tumor microenvironment gene expression Open
Background Several canine breeds, including boxers, Boston terriers, and French bulldogs, belong to the same phylogenetic clade and have a higher risk for high-grade oligodendroglioma (HGO) than the general canine population. Despite their…
View article: Epidemiological Evaluation of Neuter Status, Sex, and Breed in Dogs With Cystine Uroliths
Epidemiological Evaluation of Neuter Status, Sex, and Breed in Dogs With Cystine Uroliths Open
Background The majority of cystine uroliths occur in intact male dogs. Androgen‐dependent (Type III) cystinuria is considered the most common cause. Objectives Identify dog breeds in which castration is likely to decrease the risk of cysti…
View article: Association of Diet and Calcium Tartrate Tetrahydrate Uroliths in Dogs
Association of Diet and Calcium Tartrate Tetrahydrate Uroliths in Dogs Open
Background Calcium tartrate tetrahydrate (CTT) uroliths are recently identified in dogs. Objectives To report on the types and prevalence of diets, supplements, and medications containing salts of tartaric acid consumed by dogs with CTT ur…
View article: 458 Defining the impact of short-chain fatty acids on the gut–urinary axis in a naturally occurring canine model of calcium oxalate urolithiasis
458 Defining the impact of short-chain fatty acids on the gut–urinary axis in a naturally occurring canine model of calcium oxalate urolithiasis Open
Objectives/Goals: Short-chain fatty acids (SCFAs) exert protective effects against calcium oxalate (CaOx) urinary stone formation in experimental rodent models, yet these effects are not understood in natural stone formers. This study will…
View article: Expression of osteogenic proteins in kidneys of cats with nephrocalcinosis
Expression of osteogenic proteins in kidneys of cats with nephrocalcinosis Open
Background Nephrocalcinosis is a common pathological finding in cats with chronic kidney disease and nephrolithiasis. Understanding its pathogenesis may identify future therapeutic targets. Hypothesis Nephrocalcinosis is associated with ex…
View article: Biliverdinuria Caused by Exonic BLVRA Deletions in Two Dogs with Green Urine
Biliverdinuria Caused by Exonic BLVRA Deletions in Two Dogs with Green Urine Open
Background/Objectives: In heme degradation, biliverdin reductase catalyzes the conversion of biliverdin to bilirubin. Defects in the biliverdin reductase A gene (BLVRA) causing biliverdinuria are extraordinarily rare in humans, and this in…
View article: Whole blood gene expression analysis of spontaneous hypertriglyceridemia in dogs suggests an underlying pro-thrombotic process
Whole blood gene expression analysis of spontaneous hypertriglyceridemia in dogs suggests an underlying pro-thrombotic process Open
Hypertriglyceridemia (HTG) is influenced by multiple genetic and environmental factors. Spontaneous, idiopathic HTG is common in the Miniature Schnauzer dog and presumed to have a strong genetic influence in this breed. To define genes tha…
View article: Dietary Features Are Associated with Differences in the Urinary Microbiome in Clinically Healthy Adult Dogs
Dietary Features Are Associated with Differences in the Urinary Microbiome in Clinically Healthy Adult Dogs Open
Nutrition plays an important role in shaping the gut microbiome composition, although the impact of diet on the urinary microbiome (i.e., urobiome) remains unknown. The aim of this pilot study was to discover how nutritional features affec…
View article: Increased susceptibility to Mycobacterium avium complex infection in miniature Schnauzer dogs caused by a codon deletion in CARD9
Increased susceptibility to Mycobacterium avium complex infection in miniature Schnauzer dogs caused by a codon deletion in CARD9 Open
Mammals are generally resistant to Mycobacterium avium complex (MAC) infections. We report here on a primary immunodeficiency disorder causing increased susceptibility to MAC infections in a canine breed. Adult Miniature Schnauzers develop…
View article: WCN24-1683 THE HOMOLOG OF ANOCTAMIN 4 LIMITS CALCIUM OXALATE CRYSTALLIZATION BY PREVENTING GRAM-NEGATIVE BACTERIA INFECTION IN DROSOPHILA RENAL TUBULES
WCN24-1683 THE HOMOLOG OF ANOCTAMIN 4 LIMITS CALCIUM OXALATE CRYSTALLIZATION BY PREVENTING GRAM-NEGATIVE BACTERIA INFECTION IN DROSOPHILA RENAL TUBULES Open
An anoctamin 4 (ANO4) mutation was identified in dogs with calcium oxalate (CaOx) stones via GWAS, and the content of ANO4 is decreased in urinary extracellular vesicles of human CaOx stone formers. ANO proteins are Ca2+-activated Clchanne…
View article: 431 Defective uromodulin polymerization and peptide excretion in a natural canine model of kidney stones
431 Defective uromodulin polymerization and peptide excretion in a natural canine model of kidney stones Open
OBJECTIVES/GOALS: Using a natural canine model of kidney stone disease, we previously identified a pathogenic variant in the uromodulin gene (UMOD) that imparts a dramatic risk for calcium oxalate (CaOx) stones. This study was designed to …
View article: A Novel CARMIL2 Immunodeficiency Identified in a Subset of Cavalier King Charles Spaniels with Pneumocystis and Bordetella Pneumonia
A Novel CARMIL2 Immunodeficiency Identified in a Subset of Cavalier King Charles Spaniels with Pneumocystis and Bordetella Pneumonia Open
Pet dogs are a valuable natural animal model for studying relationships between primary immunodeficiencies and susceptibility to Pneumocystis and other opportunistic respiratory pathogens. Certain breeds, such as the Cavalier King Charles …
View article: Clustering analysis of lipoprotein profiles to identify subtypes of hypertriglyceridemia in <scp>Miniature Schnauzers</scp>
Clustering analysis of lipoprotein profiles to identify subtypes of hypertriglyceridemia in <span>Miniature Schnauzers</span> Open
Background Hypertriglyceridemia (HTG) is prevalent in Miniature Schnauzers, predisposing them to life‐threatening diseases. Varied responses to management strategies suggest the possibility of multiple subtypes. Hypothesis/Objective To ide…
View article: Sequence Analysis of Six Candidate Genes in Miniature Schnauzers with Primary Hypertriglyceridemia
Sequence Analysis of Six Candidate Genes in Miniature Schnauzers with Primary Hypertriglyceridemia Open
Miniature Schnauzers are predisposed to primary hypertriglyceridemia (HTG). In this study, we performed whole genome sequencing (WGS) of eight Miniature Schnauzers with primary HTG and screened for risk variants in six HTG candidate genes:…
View article: Spontaneous remission and relapse of diabetes mellitus in a male dog
Spontaneous remission and relapse of diabetes mellitus in a male dog Open
An 8‐year‐old male neutered Miniature Schnauzer was diagnosed with diabetes mellitus based on fasting hyperglycemia and glucosuria after a 2‐week history of polydipsia and periuria, in line with the Agreeing Language in Veterinary Endocrin…
View article: Development of a burst wave lithotripsy system for noninvasive fragmentation of ureteroliths in pet cats
Development of a burst wave lithotripsy system for noninvasive fragmentation of ureteroliths in pet cats Open
Background Upper urinary tract stones are increasingly prevalent in pet cats and are difficult to manage. Surgical procedures to address obstructing ureteroliths have short- and long-term complications, and medical therapies ( e.g., fluid …
View article: An ABCC9 Missense Variant Is Associated with Sudden Cardiac Death and Dilated Cardiomyopathy in Juvenile Dogs
An ABCC9 Missense Variant Is Associated with Sudden Cardiac Death and Dilated Cardiomyopathy in Juvenile Dogs Open
Sudden cardiac death in the young (SCDY) is a devastating event that often has an underlying genetic basis. Manchester Terrier dogs offer a naturally occurring model of SCDY, with sudden death of puppies as the manifestation of an inherite…
View article: The impact of urine collection method on canine urinary microbiota detection: a cross-sectional study
The impact of urine collection method on canine urinary microbiota detection: a cross-sectional study Open
Background The urinary tract harbors unique microbial communities that play important roles in urogenital health and disease. Dogs naturally suffer from several of the same urological disorders as humans (e.g., urinary tract infections, ne…
View article: Safety and efficacy of nightly nitrofurantoin as prophylaxis in dogs with recurrent urinary tract infections: 13 cases (2015‐2021)
Safety and efficacy of nightly nitrofurantoin as prophylaxis in dogs with recurrent urinary tract infections: 13 cases (2015‐2021) Open
Objectives To report the protocol, efficacy and adverse events in dogs receiving nightly nitrofurantoin therapy as antimicrobial prophylaxis for recurrent urinary tract infections. Materials and Methods Retrospective case series of dogs pr…
View article: Development of a Burst Wave Lithotripsy System for Noninvasive Fragmentation of Ureteroliths in Pet Cats
Development of a Burst Wave Lithotripsy System for Noninvasive Fragmentation of Ureteroliths in Pet Cats Open
Background: Upper urinary tract stones are increasingly prevalent in pet cats and are difficult to manage. Surgical procedures to address obstructing ureteroliths have short- and long-term complications, and medical therapies ( e.g. fluid …
View article: Characterization of the urogenital microbiome in Miniature Schnauzers with and without calcium oxalate urolithiasis
Characterization of the urogenital microbiome in Miniature Schnauzers with and without calcium oxalate urolithiasis Open
Background Calcium oxalate (CaOx) uroliths are common in dogs. Humans with CaOx urolithiasis exhibit alterations of the urinary and urogenital microbiomes that might mediate urolith formation. Detection of urogenital microbes associated wi…
View article: Targeted sequencing of candidate gene regions for myelofibrosis in dogs
Targeted sequencing of candidate gene regions for myelofibrosis in dogs Open
Background Myelofibrosis often lacks an identifiable cause in dogs. In humans, most primary myelofibrosis cases develop secondary to driver mutations in JAK2 , CALR , or MPL . Objectives To determine the prevalence of variants in JAK2, CAL…
View article: Prevalence and Predictors of Radiographically Apparent Upper Urinary Tract Urolithiasis in Eight Dog Breeds Predisposed to Calcium Oxalate Urolithiasis and Mixed Breed Dogs
Prevalence and Predictors of Radiographically Apparent Upper Urinary Tract Urolithiasis in Eight Dog Breeds Predisposed to Calcium Oxalate Urolithiasis and Mixed Breed Dogs Open
Data on upper urinary tract (UUT) uroliths in dogs are important to understanding their etiology. The aim of this retrospective case-control study was to determine the prevalence and identify predictors of radiographically apparent UUT uro…
View article: Effect of urine‐specific gravity on performance of bacteriuria in predicting urine culture results
Effect of urine‐specific gravity on performance of bacteriuria in predicting urine culture results Open
Objective To determine the effect of urine‐specific gravity (USG) on using microscopic evaluation of bacteriuria to predict urine culture results in dogs and cats. Materials and Methods We performed a retrospective medical record review of…
View article: Multiple variants in XDH and MOCOS underlie xanthine urolithiasis in dogs
Multiple variants in XDH and MOCOS underlie xanthine urolithiasis in dogs Open
Hereditary xanthinuria is a rare autosomal recessive disease caused by missense and loss of function variants in the xanthine dehydrogenase (XDH) or molybdenum cofactor sulfurase (MOCOS) genes. The aim of this study was to uncover variants…
View article: Efficacy of medical dissolution for suspected struvite cystoliths in dogs
Efficacy of medical dissolution for suspected struvite cystoliths in dogs Open
Background Medical dissolution of struvite uroliths in dogs is commonly recommended, but data on success rates and complications are limited. Objectives To evaluate the efficacy of medical dissolution for suspected struvite cystoliths in d…
View article: MP07-06 CALCIUM OXALATE STONES, BLOOD IONIZED CALCIUM, AND HYPERCALCIURIA ARE ASSOCIATED WITH GENES AFFECTING ARACHIDONIC ACID METABOLISM IN A DOG MODEL
MP07-06 CALCIUM OXALATE STONES, BLOOD IONIZED CALCIUM, AND HYPERCALCIURIA ARE ASSOCIATED WITH GENES AFFECTING ARACHIDONIC ACID METABOLISM IN A DOG MODEL Open
You have accessJournal of UrologyStone Disease: Basic Research & Pathophysiology (MP07)1 Sep 2021MP07-06 CALCIUM OXALATE STONES, BLOOD IONIZED CALCIUM, AND HYPERCALCIURIA ARE ASSOCIATED WITH GENES AFFECTING ARACHIDONIC ACID METABOLISM IN A…
View article: Association analysis of dopamine transporter gene (<i>SLC6A3</i>) variants with risk for seizures and aggression in Border Collies
Association analysis of dopamine transporter gene (<i>SLC6A3</i>) variants with risk for seizures and aggression in Border Collies Open
Genotyping results are presented in the manuscript Table 1.
View article: Retrospective analysis of the effects of <i>Blastomyces</i> antigen concentration in urine and radiographic findings on survival in dogs with blastomycosis
Retrospective analysis of the effects of <i>Blastomyces</i> antigen concentration in urine and radiographic findings on survival in dogs with blastomycosis Open
Background The Blastomyces antigen concentration in urine (BACU) test is used to diagnose blastomycosis and monitor treatment in dogs. It is unknown if a higher BACU is associated with shorter survival. Objectives To determine if the magni…