Eva Geissinger
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View article: Panel Sequencing of Primary Cutaneous B-Cell Lymphoma
Panel Sequencing of Primary Cutaneous B-Cell Lymphoma Open
Background: Primary cutaneous follicular B-cell lymphoma (PCFBCL) represents an indolent subtype of Non-Hodgkin’s lymphomas, being clinically characterized by slowly growing tumors of the skin and common cutaneous relapses, while only exhi…
View article: Treatment of mycosis fungoides with brentuximab vedotin: Assessing <scp>CD30</scp> expression by immunohistochemistry and quantitative real‐time polymerase chain reaction
Treatment of mycosis fungoides with brentuximab vedotin: Assessing <span>CD30</span> expression by immunohistochemistry and quantitative real‐time polymerase chain reaction Open
Brentuximab vedotin (BV), an anti-CD30 antibody conjugated with the cytotoxic agent monomethyl auristatin E (MMAE), has achieved significant therapeutic success in CD30-positive cutaneous T-cell lymphomas (CTCL).1 Microscopic evaluation of…
View article: Targeted Deep Sequencing of Mycosis Fungoides Reveals Intracellular Signaling Pathways Associated with Aggressiveness and Large Cell Transformation
Targeted Deep Sequencing of Mycosis Fungoides Reveals Intracellular Signaling Pathways Associated with Aggressiveness and Large Cell Transformation Open
Introduction: Large-cell transformation (LCT) of mycosis fungoides (MF) has been associated with a higher risk of relapse and progression and, consequently, restricted prognosis. Its molecular pathogenesis has not been elucidated yet. Mate…
View article: Oncogenic Mutations and Gene Fusions in CD30-Positive Lymphoproliferations and Clonally Related Mycosis Fungoides Occurring in the Same Patients
Oncogenic Mutations and Gene Fusions in CD30-Positive Lymphoproliferations and Clonally Related Mycosis Fungoides Occurring in the Same Patients Open
The emergence of a common progenitor cell has been postulated for the association of CD30-positive lymphoproliferative disease (LPD) and mycosis fungoides (MF) within the same patient. Up to now, no comprehensive analysis has yet addressed…
View article: <scp>EBER</scp> in situ hybridization in subcutaneous aluminum granulomas/lymphoid hyperplasia: A diagnostic clue to differentiate injection‐associated lymphoid hyperplasia from other forms of pseudolymphomas and cutaneous lymphomas
<span>EBER</span> in situ hybridization in subcutaneous aluminum granulomas/lymphoid hyperplasia: A diagnostic clue to differentiate injection‐associated lymphoid hyperplasia from other forms of pseudolymphomas and cutaneous lymphomas Open
Background Subcutaneous vaccination or desensitization may induce persistent nodules at the injection sites. Without the knowledge of prior injection, histopathological work‐up may be challenging. Objective Aim of this study was to contrib…
View article: The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression
The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression Open
The transcription factor NRF2 is the major mediator of oxidative stress responses and is closely connected to therapy resistance in tumors harboring activating mutations in the NRF2 pathway. In melanoma, such mutations are rare, and it is …
View article: Neoadjuvant immunotherapy with combined ipilimumab and nivolumab in patients with melanoma with primary or in transit disease
Neoadjuvant immunotherapy with combined ipilimumab and nivolumab in patients with melanoma with primary or in transit disease Open
The introduction of new therapeutic agents has revolutionized the treatment of metastatic melanoma. The approval of adjuvant anti-programmed death-1 monotherapy with nivolumab or pembrolizumab, and dabrafenib plus trametinib has recently s…
View article: T‐cell pseudolymphoma in recurrent herpes simplex virus infection
T‐cell pseudolymphoma in recurrent herpes simplex virus infection Open
Background In cases of herpes virus infection without typical histologic (and clinical) signs it is difficult to achieve the correct diagnosis by histology alone. Some of those cases are prone to be misdiagnosed as cutaneous lymphoma. Meth…
View article: Genomic Profiling Identifies Outcome-Relevant Mechanisms of Innate and Acquired Resistance to Third-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy in Lung Cancer
Genomic Profiling Identifies Outcome-Relevant Mechanisms of Innate and Acquired Resistance to Third-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy in Lung Cancer Open
PURPOSE Third-generation epidermal growth factor receptor ( EGFR) tyrosine kinase inhibitors (TKIs) are effective in acquired resistance (AR) to early-generation EGFR TKIs in EGFR-mutant lung cancer. However, efficacy is marked by interind…
View article: The PROCLIPI international registry of early‐stage mycosis fungoides identifies substantial diagnostic delay in most patients
The PROCLIPI international registry of early‐stage mycosis fungoides identifies substantial diagnostic delay in most patients Open
This confirmed early-stage MF cohort is being followed-up to identify prognostic factors, which may allow better management and improve survival by identifying patients at risk of disease progression. This study design is a useful model fo…
View article: Paraproteinaemia in Primary Cutaneous Marginal Zone Lymphoma
Paraproteinaemia in Primary Cutaneous Marginal Zone Lymphoma Open
Primary cutaneous marginal zone lymphomas (PCMZL) frequently exhibit lymphoplasmacytoid/plasmacytic differentiation, implying the capacity to produce monoclonal immunoglobulins. As these paraproteins are secreted, and thus are measurable i…
View article: First-line therapy of peripheral T-cell lymphoma: extension and long-term follow-up of a study investigating the role of autologous stem cell transplantation
First-line therapy of peripheral T-cell lymphoma: extension and long-term follow-up of a study investigating the role of autologous stem cell transplantation Open
Current guidelines recommend consolidation with autologous stem cell transplantation (autoSCT) after induction chemotherapy for most patients with peripheral T-cell lymphoma (PTCL). This assumption is based on five prospective phase II stu…