Eva Hellsberg
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View article: The Role of Chloride Ions in Serotonin Transport
The Role of Chloride Ions in Serotonin Transport Open
The human serotonin transporter SERT facilitates serotonin (5-HT + ) transport into cells by coupling to Na + co-transport and K + exchange. Although extracellular Cl − is also essential for transport, whether Cl − ions are transported has…
View article: Careful Examination of a Novel Azobenzene Paroxetine Derivative and Its Interactions With Biogenic Amine Transporters
Careful Examination of a Novel Azobenzene Paroxetine Derivative and Its Interactions With Biogenic Amine Transporters Open
The serotonin transporter (SERT) belongs to the family of neurotransmitter sodium symporters (NSS), together with other neurotransmitter transporters for norepinephrine, dopamine, glycine, and GABA. The main physiological role of SERT is t…
View article: Identification of the potassium-binding site in serotonin transporter
Identification of the potassium-binding site in serotonin transporter Open
Clearance of serotonin (5-hydroxytryptamine, 5-HT) from the synaptic cleft after neuronal signaling is mediated by serotonin transporter (SERT), which couples this process to the movement of a Na + ion down its chemical gradient. After rel…
View article: Identification of the potassium binding site in serotonin transporter SERT
Identification of the potassium binding site in serotonin transporter SERT Open
Clearance of serotonin (5-hydroxytryptamine, 5-HT) from the synaptic cleft after neuronal signaling is mediated by serotonin transporter SERT, which couples this process to the movement of a Na + ion down its chemical gradient. After relea…
View article: Allosteric modulators of solute carrier function: a theoretical framework
Allosteric modulators of solute carrier function: a theoretical framework Open
Large-scale drug screening is currently the basis for the identification of new chemical entities. This is a rather laborious approach, because a large number of compounds must be tested to cover the chemical space in an unbiased fashion. …
View article: A structural model of the human serotonin transporter in an outward-occluded state
A structural model of the human serotonin transporter in an outward-occluded state Open
The human serotonin transporter hSERT facilitates the reuptake of its endogenous substrate serotonin from the synaptic cleft into presynaptic neurons after signaling. Reuptake regulates the availability of this neurotransmitter and therefo…
View article: A structural model of the human serotonin transporter in an outward-occluded state: MD simulation data
A structural model of the human serotonin transporter in an outward-occluded state: MD simulation data Open
The uploads contain relevant data to supplement the study https://www.biorxiv.org/content/10.1101/637009v1, where the details of the methods are described. charmm_energy_minimization.inp is the input file that was used to run an energy min…
View article: A structural model of the human serotonin transporter in an outward-occluded state: MD simulation data
A structural model of the human serotonin transporter in an outward-occluded state: MD simulation data Open
The uploads contain relevant data to supplement the study https://www.biorxiv.org/content/10.1101/637009v1, where the details of the methods are described. charmm_energy_minimization.inp is the input file that was used to run an energy min…
View article: A structural model of the human serotonin transporter in an outward-occluded state
A structural model of the human serotonin transporter in an outward-occluded state Open
The human serotonin transporter hSERT facilitates the reuptake of its endogenous substrate serotonin from the synaptic cleft into presynaptic neurons after signaling. Reuptake regulates the availability of this neurotransmitter and therefo…
View article: Correction: From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter
Correction: From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter Open
Correction for 'From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter’ by Barbara Zdrazil et al., Med. Chem. Commun., 2016, 7, 1819–1831.
View article: From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter
From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter Open
Retrieval of consistent SAR data sets is a challenging task. Combining integrated open data sources with workflow tools allows studying selectivity trends of compound series.