Eva Hesius
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View article: CD151 interacts with integrin beta 2 in B cell lymphomas
CD151 interacts with integrin beta 2 in B cell lymphomas Open
CD151 is a broadly expressed four-transmembrane protein (tetraspanin) that interacts with laminin‐binding integrins like integrin alpha 3 (ITGA3). CD151 drives tumor development and expression correlates with poor prognosis in solid cancer…
View article: Clonal Relationship and Mutation Analysis in Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia Associated With Diffuse Large B-cell Lymphoma
Clonal Relationship and Mutation Analysis in Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia Associated With Diffuse Large B-cell Lymphoma Open
Patients with lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) occasionally develop diffuse large B-cell lymphoma (DLBCL). This mostly results from LPL/WM transformation, although clonally unrelated DLBCL can also arise. L…
View article: Reclassification of diffuse large B cell lymphoma to large B cell lymphoma with <i>IRF4</i> rearrangement in an adult population
Reclassification of diffuse large B cell lymphoma to large B cell lymphoma with <i>IRF4</i> rearrangement in an adult population Open
Aims Large B cell lymphoma with IRF4 rearrangement (LBCL‐IRF4) is a new entity in the 2017 revised World Health Organisation (WHO) classification that was initially mainly reported in children. After identification of a 79‐year‐old patient…
View article: Detection of second primary lymphoma in late diffuse large B-cell lymphoma recurrences
Detection of second primary lymphoma in late diffuse large B-cell lymphoma recurrences Open
Approximately one-third of diffuse large B-cell lymphoma (DLBCL) patients relapse, who often require salvage chemotherapy followed by autologous stem cell transplantation. In most cases, the clonal relationship between the first diagnosis …
View article: Monoclonal gammopathy of renal significance presenting with cryoglobulinaemia type I associated severe thrombotic microangiopathy
Monoclonal gammopathy of renal significance presenting with cryoglobulinaemia type I associated severe thrombotic microangiopathy Open
We report a 53-year-old man who presented with acute renal failure. His medical history revealed a spondyloarthropathy, for which secukinumab was started recently, and a monoclonal gammopathy of unknown significance. Kidney function deteri…
View article: IRF8 is a transcriptional activator of CD37 expression in diffuse large B-cell lymphoma
IRF8 is a transcriptional activator of CD37 expression in diffuse large B-cell lymphoma Open
Diffuse large B-cell lymphoma (DLBCL) represents the most common form of non-Hodgkin lymphoma (NHL) that is still incurable in a large fraction of patients. Tetraspanin CD37 is highly expressed on mature B lymphocytes, and multiple CD37-ta…