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View article: Microplastics and Their Impact on Reproduction—Can we Learn From the C. elegans Model?
Microplastics and Their Impact on Reproduction—Can we Learn From the C. elegans Model? Open
Biologically active environmental pollutants have significant impact on ecosystems, wildlife, and human health. Microplastic (MP) and nanoplastic (NP) particles are pollutants that are present in the terrestrial and aquatic ecosystems at v…
View article: Modelling the functional genomics of Parkinson’s disease in<i>Caenorhabditis elegans</i>:<i>LRRK2</i>and beyond
Modelling the functional genomics of Parkinson’s disease in<i>Caenorhabditis elegans</i>:<i>LRRK2</i>and beyond Open
For decades, Parkinson’s disease (PD) cases have been genetically categorised into familial, when caused by mutations in single genes with a clear inheritance pattern in affected families, or idiopathic, in the absence of an evident monoge…
View article: Inhibition of the activin receptor improves cardiac remodelling in the ercc1 mouse model of accelerated ageing
Inhibition of the activin receptor improves cardiac remodelling in the ercc1 mouse model of accelerated ageing Open
Introduction In the heart, ageing is associated with pathological remodelling due to an increase of DNA damage, oxidative stress and fibrosis that impairs function, often leading to heart failure. Ageing is also associated with activation …
View article: The Machado–Joseph disease deubiquitylase ataxin‐3 interacts with LC3C/GABARAP and promotes autophagy
The Machado–Joseph disease deubiquitylase ataxin‐3 interacts with LC3C/GABARAP and promotes autophagy Open
The pathology of spinocerebellar ataxia type 3, also known as Machado‐Joseph disease, is triggered by aggregation of toxic ataxin‐3 (ATXN3) variants containing expanded polyglutamine repeats. The physiological role of this deubiquitylase, …
View article: Repair or destruction—an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis
Repair or destruction—an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis Open
Cellular differentiation, developmental processes, and environmental factors challenge the integrity of the proteome in every eukaryotic cell. The maintenance of protein homeostasis, or proteostasis, involves folding and degradation of dam…