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View article: Cross-Linking Mass Spectrometry on P-Glycoprotein
Cross-Linking Mass Spectrometry on P-Glycoprotein Open
The ABC transporter P-glycoprotein (Pgp) has been found to be involved in multidrug resistance in tumor cells. Lipids and cholesterol have a pivotal role in Pgp’s conformations; however, it is often difficult to investigate it with convent…
View article: Proteotranscriptomic Discrimination of Tumor and Normal Tissues in Renal Cell Carcinoma
Proteotranscriptomic Discrimination of Tumor and Normal Tissues in Renal Cell Carcinoma Open
Clear cell renal carcinoma is the most frequent type of kidney cancer, with an increasing incidence rate worldwide. In this research, we used a proteotranscriptomic approach to differentiate normal and tumor tissues in clear cell renal cel…
View article: The ROP2 GTPase Participates in Nitric Oxide (NO)-Induced Root Shortening in Arabidopsis
The ROP2 GTPase Participates in Nitric Oxide (NO)-Induced Root Shortening in Arabidopsis Open
Nitric oxide (NO) is a versatile signal molecule that mediates environmental and hormonal signals orchestrating plant development. NO may act via reversible S-nitrosation of proteins during which an NO moiety is added to a cysteine thiol t…
View article: A novel <scp>BRET</scp> ‐Based <scp>GAP</scp> assay reveals phosphorylation‐dependent regulation of the <scp>RAC</scp> ‐specific <scp>GTPase</scp> activating protein <scp>ARHGAP25</scp>
A novel <span>BRET</span> ‐Based <span>GAP</span> assay reveals phosphorylation‐dependent regulation of the <span>RAC</span> ‐specific <span>GTPase</span> activating protein <span>ARHGAP25</span> Open
ARHGAP25, a RAC‐specific GTPase activating protein (GAP), is an essential regulator of phagocyte effector functions such as phagocytosis, superoxide production, and transendothelial migration. Furthermore, its complex role in tumor behavio…
View article: STABILON, a Novel Sequence Motif That Enhances the Expression and Accumulation of Intracellular and Secreted Proteins
STABILON, a Novel Sequence Motif That Enhances the Expression and Accumulation of Intracellular and Secreted Proteins Open
The dynamic balance of transcriptional and translational regulation together with degron-controlled proteolysis shapes the ever-changing cellular proteome. While a large variety of degradation signals has been characterized, our knowledge …
View article: The Small Heat Shock Protein, HSPB1, Interacts with and Modulates the Physical Structure of Membranes
The Small Heat Shock Protein, HSPB1, Interacts with and Modulates the Physical Structure of Membranes Open
Small heat shock proteins (sHSPs) have been demonstrated to interact with lipids and modulate the physical state of membranes across species. Through these interactions, sHSPs contribute to the maintenance of membrane integrity. HSPB1 is a…
View article: Phosphorylation Pattern of ARHGAP25 Determines its Regulatory Effect in Different Conditions.
Phosphorylation Pattern of ARHGAP25 Determines its Regulatory Effect in Different Conditions. Open
ARHGAP25 is highly phosphorylated in its interdomain region.raw files of in vivo and in vitro phosphorylation analyses191213_14.raw recombinant ARHGAP25 tryptic 191213_17.raw recombinant ARHGAP25 phospho enriched191214_17_WE_2+bioID.raw CO…
View article: Phosphorylation Pattern of ARHGAP25 Determines its Regulatory Effect in Different Conditions.
Phosphorylation Pattern of ARHGAP25 Determines its Regulatory Effect in Different Conditions. Open
ARHGAP25 is highly phosphorylated in its interdomain region.raw files of in vivo and in vitro phosphorylation analyses191213_14.raw recombinant ARHGAP25 tryptic 191213_17.raw recombinant ARHGAP25 phospho enriched191214_17_WE_2+bioID.raw CO…
View article: Phosphorylation Pattern of ARHGAP25 Determines its Regulatory Effect in Different Conditions.
Phosphorylation Pattern of ARHGAP25 Determines its Regulatory Effect in Different Conditions. Open
ARHGAP25 is highly phosphorylated in its interdomain region.raw files of in vivo and in vitro phosphorylation analyses
View article: The Arabidopsis Rho of Plants GTPase ROP1 Is a Potential Calcium-Dependent Protein Kinase (CDPK) Substrate
The Arabidopsis Rho of Plants GTPase ROP1 Is a Potential Calcium-Dependent Protein Kinase (CDPK) Substrate Open
Plant Rho-type GTPases (ROPs) are versatile molecular switches involved in a number of signal transduction pathways. Although it is well known that they are indirectly linked to protein kinases, our knowledge about their direct functional …
View article: Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants
Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants Open
Phytochromes are photoreceptors regulating growth and development in plants. Using the model plant Arabidopsis, we identified a novel signalling pathway downstream of the far-red light-sensing phytochrome, phyA, that depends on the highly …
View article: Author response: Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants
Author response: Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Phytochromes are photorecepto…
View article: Potent Chimeric Antimicrobial Derivatives of the Medicago truncatula NCR247 Symbiotic Peptide
Potent Chimeric Antimicrobial Derivatives of the Medicago truncatula NCR247 Symbiotic Peptide Open
In Rhizobium-legume symbiosis, the bacteria are converted into nitrogen-fixing bacteroids. In many legume species, differentiation of the endosymbiotic bacteria is irreversible, culminating in definitive loss of their cell division ability…
View article: CRK5 Protein Kinase Contributes to the Progression of Embryogenesis of Arabidopsis thaliana
CRK5 Protein Kinase Contributes to the Progression of Embryogenesis of Arabidopsis thaliana Open
The fine tuning of hormone (e.g., auxin and gibberellin) levels and hormone signaling is required for maintaining normal embryogenesis. Embryo polarity, for example, is ensured by the directional movement of auxin that is controlled by var…
View article: Differential phosphorylation of the N‐terminal extension regulates phytochrome B signaling
Differential phosphorylation of the N‐terminal extension regulates phytochrome B signaling Open
Summary Phytochrome B (phyB) is an excellent light quality and quantity sensor that can detect subtle changes in the light environment. The relative amounts of the biologically active photoreceptor (phyB Pfr) are determined by the light co…
View article: The mitogen-activated protein kinase 4-phosphorylated heat shock factor A4A regulates responses to combined salt and heat stresses
The mitogen-activated protein kinase 4-phosphorylated heat shock factor A4A regulates responses to combined salt and heat stresses Open
Heat shock factors regulate responses to high temperature, salinity, water deprivation, or heavy metals. Their function in combinations of stresses is, however, not known. Arabidopsis HEAT SHOCK FACTOR A4A (HSFA4A) was previously reported …
View article: Hsp70-associated chaperones have a critical role in buffering protein production costs
Hsp70-associated chaperones have a critical role in buffering protein production costs Open
Proteins are necessary for cellular growth. Concurrently, however, protein production has high energetic demands associated with transcription and translation. Here, we propose that activity of molecular chaperones shape protein burden, th…
View article: Author response: Hsp70-associated chaperones have a critical role in buffering protein production costs
Author response: Hsp70-associated chaperones have a critical role in buffering protein production costs Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Proteins are necessary for ce…
View article: Extracellular Protein Phosphorylation, the Neglected Side of the Modification
Extracellular Protein Phosphorylation, the Neglected Side of the Modification Open
The very existence of extracellular phosphorylation has been questioned for a long time, although casein phosphorylation was discovered a century ago. In addition, several modification sites localized on secreted proteins or on extracellul…