Eva M. Stevenson
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View article: No evidence that circulating HIV-specific immune responses contribute to persistent inflammation and immune activation in persons on long-term ART
No evidence that circulating HIV-specific immune responses contribute to persistent inflammation and immune activation in persons on long-term ART Open
OBJECTIVE: People with HIV (PWH) have persistently elevated levels of inflammation and immune activation despite suppressive antiretroviral therapy (ART), with specific biomarkers showing associations with non-AIDS-defining morbidities and…
View article: Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins
Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins Open
Viruses employ a variety of strategies to escape or counteract immune responses, including depletion of cell surface major histocompatibility complex class I (MHC-I), that would ordinarily present viral peptides to CD8 + cytotoxic T cells.…
View article: No evidence that circulating HIV-specific immune responses contribute to persistent inflammation and immune activation in persons on long-term ART
No evidence that circulating HIV-specific immune responses contribute to persistent inflammation and immune activation in persons on long-term ART Open
Objective: People with HIV (PWH) have persistently elevated levels of inflammation and immune activation despite suppressive antiretroviral therapy (ART), with specific biomarkers showing associations with non-AIDS-defining morbidities and…
View article: Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins
Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins Open
Viruses employ a variety of strategies to escape or counteract immune responses, including depletion of cell surface major histocompatibility complex class I (MHC-I), that would ordinarily present viral peptides to CD8+ cytotoxic T cells. …
View article: SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells
SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells Open
Efforts to cure HIV have focused on reactivating latent proviruses to enable elimination by CD8+ cytotoxic T-cells. Clinical studies of latency reversing agents (LRA) in individuals treated with antiretroviral therapy (ART) have shown incr…
View article: No Evidence that Ongoing HIV-Specific Immune Responses Contribute to Persistent Inflammation and Immune Activation in Persons on Long-Term ART
No Evidence that Ongoing HIV-Specific Immune Responses Contribute to Persistent Inflammation and Immune Activation in Persons on Long-Term ART Open
Background People with HIV (PWH) have persistently elevated levels of inflammation and immune activation despite suppressive antiretroviral therapy (ART), with specific biomarkers showing associations with non-AIDS-defining morbidities and…
View article: Characterizing the Relationship Between Neutralization Sensitivity and env Gene Diversity During ART Suppression
Characterizing the Relationship Between Neutralization Sensitivity and env Gene Diversity During ART Suppression Open
Although antiretroviral therapy (ART) successfully suppresses HIV-1 replication, ART-treated individuals must maintain therapy to avoid rebound from an integrated viral reservoir. Strategies to limit or clear this reservoir are urgently ne…
View article: A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies
A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies Open
HIV-specific CD8+ T cells partially control viral replication and delay disease progression, but they rarely provide lasting protection, largely due to immune escape. Here, we show that engrafting mice with memory CD4+ T cells from HIV+ do…
View article: HIV-specific T cell responses reflect substantive in vivo interactions with antigen despite long-term therapy
HIV-specific T cell responses reflect substantive in vivo interactions with antigen despite long-term therapy Open
Antiretroviral therapies (ARTs) abrogate HIV replication; however, infection persists as long-lived reservoirs of infected cells with integrated proviruses, which reseed replication if ART is interrupted. A central tenet of our current und…
View article: SARS-CoV-2–specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein
SARS-CoV-2–specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein Open
T-cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been described in recovered patients, and may be important for immunity following infection and vaccination as well as for the development of an adoptive…
View article: HIV-specific T-cell responses reflect substantive in vivo interactions with infected cells despite long-term therapy
HIV-specific T-cell responses reflect substantive in vivo interactions with infected cells despite long-term therapy Open
Antiretroviral therapies (ART) durably suppress HIV replication to undetectable levels – however, infection persists in the form of long-lived reservoirs of infected cells with integrated proviruses, that re-seed systemic replication if AR…
View article: 4308 DEEP-PRIMED IL-15 SUPERAGONIST IMPROVES ANTIVIRAL EFFICACY OF HIV-SPECIFIC CD8<sup>+</sup> T-CELLS IN HUMANIZED MOUSE MODEL
4308 DEEP-PRIMED IL-15 SUPERAGONIST IMPROVES ANTIVIRAL EFFICACY OF HIV-SPECIFIC CD8<sup>+</sup> T-CELLS IN HUMANIZED MOUSE MODEL Open
OBJECTIVES/GOALS: HIV-specific CD8 + T-cells play a critical role in partially controlling viral replication in infected-individuals, but ultimately fail to eliminate infection. Enhancing these T-cell responses through lymphocyte engineeri…
View article: T cells with high PD-1 expression are associated with lower HIV-specific immune responses despite long-term antiretroviral therapy
T cells with high PD-1 expression are associated with lower HIV-specific immune responses despite long-term antiretroviral therapy Open
PD-1 T cells persist in blood despite prolonged suppression on ART, correlate with HIV DNA levels, and are associated with lower HIV-specific T-cell responses but not CMV-specific or EBV-specific responses, suggesting that these cells are …