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View article: Associations of lifestyle factors with amyloid pathology in persons without dementia
Associations of lifestyle factors with amyloid pathology in persons without dementia Open
Background The association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood. Objective The aim of this study was to assess the association of alcohol consumption, smoking behavior, slee…
View article: Gut Microbiome Alterations in Mild Cognitive Impairment: Findings from the ALBION Greek Cohort
Gut Microbiome Alterations in Mild Cognitive Impairment: Findings from the ALBION Greek Cohort Open
Emerging evidence suggests a potential role of gut dysbiosis in neurodegenerative disorders and, in particular, Alzheimer’s disease (AD) pathology and cognitive decline. However, the role of gut microbiome in the early prodromal stages of …
View article: Associations of moderate alcohol intake with cerebrospinal fluid biomarkers of Alzheimer’s disease: data from the ALBION study
Associations of moderate alcohol intake with cerebrospinal fluid biomarkers of Alzheimer’s disease: data from the ALBION study Open
Purpose According to a WHO statement, it has been asserted that there is no safe level of alcohol consumption regarding human health. Nevertheless, the relationship between alcohol consumption and Alzheimer’s disease (AD) pathology remains…
View article: Genetic Prοpensity for Different Aspects of Dementia Pathology and Cognitive Decline in a Community Elderly Population
Genetic Prοpensity for Different Aspects of Dementia Pathology and Cognitive Decline in a Community Elderly Population Open
In the present study, we investigated the association of genetic predisposition with specific dimensions of dementia pathophysiology for global and domain-specific cognitive decline in older adults. The sample was drawn from the Hellenic L…
View article: Depressive Symptoms and Amyloid Pathology
Depressive Symptoms and Amyloid Pathology Open
Importance Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association betwee…
View article: Sleep architecture in Alzheimer’s disease continuum: The deep sleep question
Sleep architecture in Alzheimer’s disease continuum: The deep sleep question Open
As sleep appears to be closely related to cognitive status, we aimed to explore the association between the percentage of deep sleep, cognitive state, and the cerebrospinal fluid (CSF) biomarker amyloid-beta 42 in non-demented individuals.…
View article: Comparison of cerebrospinal fluid and plasma oxidative stress biomarkers
Comparison of cerebrospinal fluid and plasma oxidative stress biomarkers Open
Background Numerous studies have highlighted the role of oxidative stress in Alzheimer's disease (AD) development. Yet, the alignment of systemic and central oxidative stress biomarkers is unclear across diverse populations in the AD conti…
View article: Association of Blood Redox Markers with Alzheimer Disease Biomarkers and Cognitive Performance
Association of Blood Redox Markers with Alzheimer Disease Biomarkers and Cognitive Performance Open
Background Oxidative stress has been implicated in the pathogenesis of Alzheimer’s disease (AD). Nevertheless, whether redox perturbations are associated with cognition and AD pathology in the preclinical AD stages, remains unclear. We exa…
View article: Comparison of cerebrospinal fluid and plasma oxidative stress biomarkers
Comparison of cerebrospinal fluid and plasma oxidative stress biomarkers Open
Background Numerous studies have highlighted the role of oxidative stress in Alzheimer’s disease (AD) development. Yet, the alignment of systemic and central oxidative stress biomarkers is unclear across diverse populations in the AD conti…
View article: Objective Sleep Function is Associated with Hippocampal Subfield Volumes in Community-Dwelling Adults
Objective Sleep Function is Associated with Hippocampal Subfield Volumes in Community-Dwelling Adults Open
Background: Sleep patterns often shift as people age, a phenomenon frequently associated with the onset of neurodegenerative conditions. Additionally, distinct alterations occur in brain structure as individuals grow older, particularly wi…
View article: The Association between Individual Food Groups, Limbic System White Matter Tracts, and Episodic Memory: Initial Data from the Aiginition Longitudinal Biomarker Investigation of Neurodegeneration (ALBION) Study
The Association between Individual Food Groups, Limbic System White Matter Tracts, and Episodic Memory: Initial Data from the Aiginition Longitudinal Biomarker Investigation of Neurodegeneration (ALBION) Study Open
(1) Background: Many studies link food intake with clinical cognitive outcomes, but evidence for brain biomarkers, such as memory-related limbic white matter (WM) tracts, is limited. We examined the association between food groups, limbic …
View article: Cerebral Amyloidosis in Individuals with Subjective Cognitive Decline: From Genetic Predisposition to Actual Cerebrospinal Fluid Measurements
Cerebral Amyloidosis in Individuals with Subjective Cognitive Decline: From Genetic Predisposition to Actual Cerebrospinal Fluid Measurements Open
The possible relationship between Subjective Cognitive Decline (SCD) and dementia needs further investigation. In the present study, we explored the association between specific biomarkers of Alzheimer’s Disease (AD), amyloid-beta 42 (Aβ42…
View article: Distinct gut microbiota profiles may characterize amyloid beta pathology and mild cognitive impairment
Distinct gut microbiota profiles may characterize amyloid beta pathology and mild cognitive impairment Open
Gut microbiome composition has been associated with early preclinical Alzheimer’s disease (AD), as reflected by cerebrospinal fluid (CSF) amyloid beta pathology, and with mild cognitive impairment (MCI). However, the presence of distinct m…
View article: Genetic Predisposition for White Matter Hyperintensities and Risk of Mild Cognitive Impairment and Alzheimer’s Disease: Results from the HELIAD Study
Genetic Predisposition for White Matter Hyperintensities and Risk of Mild Cognitive Impairment and Alzheimer’s Disease: Results from the HELIAD Study Open
The present study investigated the association of genetic predisposition for white matter hyperintensities (WMHs) with incident amnestic mild cognitive impairment (aMCI) or Alzheimer’s disease (AD), as well as whether such an association w…
View article: Exploring Verbal Fluency Strategies among Individuals with Normal Cognition, Amnestic and Non-Amnestic Mild Cognitive Impairment, and Alzheimer’s Disease
Exploring Verbal Fluency Strategies among Individuals with Normal Cognition, Amnestic and Non-Amnestic Mild Cognitive Impairment, and Alzheimer’s Disease Open
Background and Objectives: The present study explored the utilization of verbal fluency (VF) cognitive strategies, including clustering, switching, intrusions, and perseverations, within both semantic (SVF) and phonemic (PVF) conditions, a…
View article: Objective Physical Function in the Alzheimer’s Disease Continuum: Association with Cerebrospinal Fluid Biomarkers in the ALBION Study
Objective Physical Function in the Alzheimer’s Disease Continuum: Association with Cerebrospinal Fluid Biomarkers in the ALBION Study Open
Cognitive and physical decline, both indicators of aging, seem to be associated with each other. The aim of the present study was to investigate whether physical function parameters (walking time and handgrip strength) are related to cereb…
View article: Subjective Cognitive Decline as a predictor of Frailty in older adults: Hellenic Longitudinal Investigation of Aging and Diet study (HELIAD)
Subjective Cognitive Decline as a predictor of Frailty in older adults: Hellenic Longitudinal Investigation of Aging and Diet study (HELIAD) Open
Subjective cognitive decline (SCD) is a self-evaluation of cognitive impairment, in the absence of observed objective cognitive deficits on a neuropsychological assessment. Frailty refers to a multidimensional syndrome where the individual…
View article: Longitudinal Examination of Body Mass Index and Cognitive Function in Older Adults: The HELIAD Study
Longitudinal Examination of Body Mass Index and Cognitive Function in Older Adults: The HELIAD Study Open
Given the increase in the aging population and thus in the prevalence of dementia, the identification of protective factors against cognitive decline is necessary. In a cohort of 1076 non-demented adults ≥ 65 years old (59.7% women) from t…
View article: A Candidate microRNA Profile for Early Diagnosis of Sporadic Alzheimer’s Disease
A Candidate microRNA Profile for Early Diagnosis of Sporadic Alzheimer’s Disease Open
Background: Late-onset or sporadic Alzheimer’s disease (sAD) is a neurodegenerative disease leading to cognitive impairment and memory loss. The underlying pathological changes take place several years prior to the appearance of the first …
View article: Simulating the multicausality of Alzheimer's disease with system dynamics
Simulating the multicausality of Alzheimer's disease with system dynamics Open
Introduction In Alzheimer's disease (AD), cognitive decline is driven by various interlinking causal factors. Systems thinking could help elucidate this multicausality and identify opportune intervention targets. Methods We developed a sys…
View article: Daily Energy Intake Distribution and Cognitive Performance in Non-Demented Individuals
Daily Energy Intake Distribution and Cognitive Performance in Non-Demented Individuals Open
Cognitive disorders have become important public health issues around the world. Studies evaluating the association between cognitive decline and food timing are lacking. The objective of this study was to examine the potential association…
View article: The Association of Adherence to the Mediterranean Diet with Depression in Older Adults Longitudinally Taking into Account Cognitive Status: Results from the HELIAD Study
The Association of Adherence to the Mediterranean Diet with Depression in Older Adults Longitudinally Taking into Account Cognitive Status: Results from the HELIAD Study Open
Although research has generally shown a negative association between depression and adherence to the Mediterranean diet (MeDi), the literature related to older adults is controversial, perhaps partially due to the fact that cognitive statu…
View article: Genetically downregulated Interleukin-6 signalling is associated with a lower risk of frailty
Genetically downregulated Interleukin-6 signalling is associated with a lower risk of frailty Open
Background numerous studies point towards a critical role of Interleukin 6 (IL-6) pathway in frailty pathogenesis yet the causal relationship between the two remains elusive. Methods we selected genetic variants near the IL-6 receptor locu…
View article: Cognitive trajectories preluding the imminent onset of Alzheimer’s disease dementia in individuals with normal cognition: results from the HELIAD cohort
Cognitive trajectories preluding the imminent onset of Alzheimer’s disease dementia in individuals with normal cognition: results from the HELIAD cohort Open
Background The cognitive trajectories of cognitively normal (CN) individuals rapidly progressing to Alzheimer’s disease dementia (AD) have not been investigated. Aim To explore the preclinical pattern of cognitive performance heralding the…
View article: Language performance as a prognostic factor for developing Alzheimer’s clinical syndrome and mild cognitive impairment: Results from the population-based HELIAD cohort
Language performance as a prognostic factor for developing Alzheimer’s clinical syndrome and mild cognitive impairment: Results from the population-based HELIAD cohort Open
Objectives: There is limited research on the prognostic value of language tasks regarding mild cognitive impairment (MCI) and Alzheimer’s clinical syndrome (ACS) development in the cognitively normal (CN) elderly, as well as MCI to ACS con…
View article: Initial Data and a Clinical Diagnosis Transition for the Aiginition Longitudinal Biomarker Investigation of Neurodegeneration (ALBION) Study
Initial Data and a Clinical Diagnosis Transition for the Aiginition Longitudinal Biomarker Investigation of Neurodegeneration (ALBION) Study Open
Background and Objectives: This article presents data from the ongoing Aiginition Longitudinal Biomarker Investigation of Neurodegeneration study (ALBION) regarding baseline clinical characterizations and CSF biomarker profiles, as well as…
View article: The Longitudinal Association of Lifestyle with Cognitive Health and Dementia Risk: Findings from the HELIAD Study
The Longitudinal Association of Lifestyle with Cognitive Health and Dementia Risk: Findings from the HELIAD Study Open
The aim of the current study was to investigate whether a Total Lifestyle Index (TLI), including adherence to the Mediterranean diet, sleep duration, physical activity and engagement in activities of daily living, is associated with cognit…
View article: Sex Differences in Frailty Incidence in Greek Community-Dwelling Older People: The HELIAD Study
Sex Differences in Frailty Incidence in Greek Community-Dwelling Older People: The HELIAD Study Open
Differences between the two sexes indicate that when exploring the factors that are related to frailty, studies should provide data disaggregated for men and women.
View article: Longitudinal episodic memory trajectories in older adults with normal cognition
Longitudinal episodic memory trajectories in older adults with normal cognition Open
To determine the longitudinal trajectories and normative standards of episodic memory in older adults. Participants were drawn from the cognitively normal(CN) subgroup of the population-based HELIAD cohort, a fairly representative cohort o…