Eva Rieser
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View article: LUBAC is required for RIG-I sensing of RNA viruses
LUBAC is required for RIG-I sensing of RNA viruses Open
The ability of cells to mount an interferon response to virus infections depends on intracellular nucleic acid sensing pattern recognition receptors (PRRs). RIG-I is an intracellular PRR that binds short double stranded viral RNAs to trigg…
View article: Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis Open
Metastasis is the major cause of death in cancer patients. Circulating tumor cells need to migrate through the endothelial layer of blood vessels to escape the hostile circulation and establish metastases at distant organ sites. Here, we i…
View article: LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation
LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation Open
The linear ubiquitin chain assembly complex (LUBAC), consisting of SHANK-associated RH-domain–interacting protein (SHARPIN), heme-oxidized IRP2 ubiquitin ligase-1 (HOIL-1), and HOIL-1–interacting protein (HOIP), is a critical regulator of …