Eva Rollerová
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View article: PEG-Polymeric Nanocarriers Alleviate the Immunosuppressive Effects of Free 4-Thiazolidinone-Based Chemotherapeutics on T Lymphocyte Function and Cytokine Production
PEG-Polymeric Nanocarriers Alleviate the Immunosuppressive Effects of Free 4-Thiazolidinone-Based Chemotherapeutics on T Lymphocyte Function and Cytokine Production Open
The drug complexation with novel PEGylated carriers is a promising way for efficient therapeutic development.
View article: Gold and titania nanoparticles accumulated in the body induce late toxic effects and alterations in transcriptional and miRNA landscape
Gold and titania nanoparticles accumulated in the body induce late toxic effects and alterations in transcriptional and miRNA landscape Open
Conventional toxicological methods and integrated transcriptomic analysis were used to comprehensively assess the potential health hazard of residual metal nanoparticles accumulated in the body due to poor solubility.
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View article: Titanium Dioxide Nanoparticles Modulate Systemic Immune Response and Increase Levels of Reduced Glutathione in Mice after Seven-Week Inhalation
Titanium Dioxide Nanoparticles Modulate Systemic Immune Response and Increase Levels of Reduced Glutathione in Mice after Seven-Week Inhalation Open
Titanium dioxide nanoparticles (TiO2 NPs) are used in a wide range of applications. Although inhalation of NPs is one of the most important toxicologically relevant routes, experimental studies on potential harmful effects of TiO2 NPs usin…
View article: Biological Analyses of the Effects of TiO2 and PEG-b-PLA Nanoparticles on Three-Dimensional Spheroid-Based Tumor
Biological Analyses of the Effects of TiO2 and PEG-b-PLA Nanoparticles on Three-Dimensional Spheroid-Based Tumor Open
The aim of our study was to monitor the antiproliferative/ cytotoxic and genotoxic effects of both, poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA) and titanium dioxide (TiO2) nanoparticles on the tumor (HT-29, MCF-7, U118MG) and…
View article: Copper Oxide Nanoparticles Stimulate the Immune Response and Decrease Antioxidant Defense in Mice After Six-Week Inhalation
Copper Oxide Nanoparticles Stimulate the Immune Response and Decrease Antioxidant Defense in Mice After Six-Week Inhalation Open
Copper oxide nanoparticles (CuO NPs) are increasingly used in various industry sectors. Moreover, medical application of CuO NPs as antimicrobials also contributes to human exposure. Their toxicity, including toxicity to the immune system …
View article: Pharmacokinetics, Biodistribution, and Biosafety of PEGylated Gold Nanoparticles In Vivo
Pharmacokinetics, Biodistribution, and Biosafety of PEGylated Gold Nanoparticles In Vivo Open
Despite the obvious advantages of gold nanoparticles for biomedical applications, controversial and incomplete toxicological data hamper their widespread use. Here, we present the results from an in vivo toxicity study using gold nanoparti…
View article: The use of <i>ex vivo</i> ovary culture for assessment of alterations in steroidogenesis following neonatal exposure to poly(ethylene glycol)-<i>block-</i>polylactide methyl ether or titanium dioxide nanoparticles in Wistar rats
The use of <i>ex vivo</i> ovary culture for assessment of alterations in steroidogenesis following neonatal exposure to poly(ethylene glycol)-<i>block-</i>polylactide methyl ether or titanium dioxide nanoparticles in Wistar rats Open
Objectives. Rapid development and widespread application of different types of nanoparticles (NPs) may result in increased exposure of humans and animals to NPs. Recently, reproductive toxicity due to NP exposure has become a major compone…
View article: Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?
Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing? Open
The unique properties of nanomaterials (NMs) are beneficial in numerous industrial and medical applications. However, they could also induce unintended effects. Thus, a proper strategy for toxicity testing is essential in human hazard and …
View article: Adverse eff ects of polymeric nanoparticle poly(ethylene glycol)- block-polylactide methyl ether (PEG-b-PLA) on steroid hormone secretion by porcine granulosa cells
Adverse eff ects of polymeric nanoparticle poly(ethylene glycol)- block-polylactide methyl ether (PEG-b-PLA) on steroid hormone secretion by porcine granulosa cells Open
Objectives. Development of nanoparticles (NPs) for biomedical applications, including medical imaging and drug delivery, is currently undergoing a dramatic expansion. Diverse effects of different type NPs relating to mammalian reproductive…
View article: Effect of Neonatal Exposure to Poly(Ethylene Glycol)‐<i>block</i>‐Poly(Lactic Acid) Nanoparticles on Oxidative State in Infantile and Adult Female Rats
Effect of Neonatal Exposure to Poly(Ethylene Glycol)‐<i>block</i>‐Poly(Lactic Acid) Nanoparticles on Oxidative State in Infantile and Adult Female Rats Open
Our goal was to evaluate the potential health risk of the polymeric NP, poly(ethylene glycol)‐ block ‐poly(lactic acid) (PEG‐ b ‐PLA), from the view of redox imbalance of the organism in two different life stages. Female Wistar rats were n…