Explanipedia

Late‐Onset Asthma Phenotypes by Onset Age: A Cluster Analysis in Swedish Population‐Based Cohorts Open

Daniil Lisik, Helena Bäckman, Rani Basna, Linnéa Hedman, Muwada Bashir Awad Bashir , et al. · 2025

Exposure to vehicle traffic in childhood and lung function in young adulthood—a prospective cohort study in an area with low traffic-flows Open

Nicolás Bermúdez Barón, Helena Bäckman, Linnéa Hedman, Eva Rönmark · 2025

Early Onset Asthma, But Not Aeroallergen Sensitization, Is Associated With Lung Function Impairment in Young Adulthood—A Prospective Cohort Study Open

Joakim Bunne, Linnéa Hedman, Anders Bjerg, Matthew S. Perzanowski, Thomas A.E. Platts‐Mills , et al. · 2025

Background Aeroallergen sensitization is a major factor in asthma, and asthma is associated with impaired lung function. The independent association between sensitization and lung function is unclear. Objectives To examine factors associat…

Late-onset asthma phenotypes by age of onset: a cluster analysis in Swedish population-based cohorts Open

Daniil Lisik, Helena Bäckman, Rani Basna, Linnéa Hedman, Muwada Bashir Awad Bashir , et al. · 2025

Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts Open

Yunus Çolak, James P. Allinson, Maarten van den Berge, Deborah Jarvis, Arnulf Langhammer , et al. · 2025

Background The extent to which airflow obstruction, a key feature of COPD, can be already present in early adulthood is unclear. We investigated the prevalence of airflow obstruction in young adults across European populations. Methods We …

All-cause and cause-specific mortality in respiratory symptom clusters: a population-based multicohort study Open

Daniil Lisik, Helena Bäckman, Hannu Kankaanranta, Rani Basna, Linnéa Hedman , et al. · 2025

Background Respiratory symptoms are common in the general adult population. Increased burden of respiratory symptoms may increase the risk of mortality. We assessed the association between respiratory symptom clusters and mortality. Method…

Self-reported Nickel Allergy among Schoolchildren: Trends in Prevalence, Risk Factors, and Atopic Comorbidity Open

Linnéa Hedman, Malin Lindberg, Berndt Stenberg, Eva Rönmark, Maja Af Klinteberg · 2025

Nickel allergy is common among children. The present study investigated prevalence trends of self-reported nickel allergy, risk factors, and atopic comorbidity among children. Eight-year-old children from Norrbotten County, Sweden, were re…

Allergic rhinitis: Incidence and remission from childhood to young adulthood—A prospective study Open

Styliana Vasileiadou, Emma Goksör, Göran Wennergren, Eva Rönmark, Linnéa Hedman · 2025

Background Longitudinal studies on allergic rhinitis (AR) incidence and remission from childhood to adulthood are limited. This study aimed to estimate AR incidence and remission from age 8 to 19 years and to identify related risk factors.…

Importance of Preserved Ratio Impaired Spirometry as a Risk Factor for Development of COPD, Also in Those Who Do Not Smoke Open

Helena Bäckman, Tomi Myrberg, Linnéa Hedman, Caroline Stridsman, Eva Rönmark , et al. · 2025

In this study, PRISm was associated with transition into AO corresponding to COPD within 1 decade, independent of smoking habits and with similar strength of association among those who have never smoked, who formerly smoked, and who curre…

Computational Phenotyping of Obstructive Airway Diseases: A Systematic Review Open

Muwada Bashir Awad Bashir, Gregorio P. Milani, Valentina De Cosmi, Alessandra Mazzocchi, Guo-Qiang Zhang , et al. · 2025

Variations in phenotyping methods, study settings, participant profiles, and variables contribute to significant differences in characterizing asthma, severe asthma, COPD, ACO, and rhinitis phenotypes across studies. Lack of reproducibilit…

Obesity predicts mortality stronger in adult‐onset asthma than in age‐ and sex‐matched controls Open

Helena Bäckman, Caroline Stridsman, Anne Lindberg, Eva Rönmark, Linnéa Hedman · 2024

Is asthma in children still increasing? 20‐year prevalence trends in northern Sweden Open

Linnéa Hedman, Martin Andersson, Anders Bjerg, Helena Bäckman, Maja Af Klinteberg , et al. · 2024

Background In the present study, we describe prevalence trends of asthma and investigate the association with asthma symptoms, use of asthma medication, and asthma severity among 8‐year‐old children in Norrbotten, Sweden in 1996, 2006, and…

Lung-function trajectories: relevance and implementation in clinical practice Open

Erik Melén, Rosa Faner, James P. Allinson, Dinh Bui, Andrew Bush , et al. · 2024

Level of Education Modifies Asthma Mortality in Norway and Sweden. The Nordic EpiLung Study Open

Helena Bäckman, Laxmi Bhatta, Linnéa Hedman, Ben Brumpton, Iida Vähätalo , et al. · 2024

Asthma was associated with an overall 71% increased all-cause mortality and 5.5% of deaths can be attributed to asthma. Educational levels modified the risk of mortality associated with asthma, with the highest risk among those with primar…

No remission in 60% of those with childhood-onset asthma - A population-based cohort followed from 8 to 28 years of age Open

Linnéa Almqvist, Martin Andersson, Helena Bäckman, Eva Rönmark, Linnéa Hedman · 2024

Stable and high incidence of asthma among adults in northern Sweden during the last decades. Open

Petri Räisänen, Helena Bäckman, Linnéa Hedman, Martin Andersson, Caroline Stridsman , et al. · 2024

Background: The prevalence of asthma has increased both among children and adults during the latter half of the 20th century. The prevalence among adults is affected by the incidence of asthma in childhood but also in adulthood. Time trend…

Electronic cigarette use in relation to changes in smokingstatus and respiratory symptoms Open

Linnéa Hedman, Gustaf Lyytinen, Helena Bäckman, Magnus Lundbäck, Caroline Stridsman , et al. · 2024

E-cigarette use was associated with persistent tobacco smoking and reporting respiratory symptoms. We found no association between e-cigarette use and tobacco smoking cessation, reduction of number of tobacco cigarettes smoked per day or r…

The interplay between obesity and blood neutrophils in adult-onset asthma Open

Helena Bäckman, Sofia Winsa Lindmark, Linnéa Hedman, Hannu Kankaanranta, Katja Warm , et al. · 2024

All-cause and cause-specific mortality by spirometric pattern and sex – a population-based cohort study Open

Helena Bäckman, Sami Sawalha, Ulf Nilsson, Linnéa Hedman, Caroline Stridsman , et al. · 2024

Background: Chronic airway obstruction (CAO) and restrictive spirometry pattern (RSP) are associated with mortality, but sex-specific patterns of all-cause and specific causes of death have hardly been evaluated. Objectives: To study the p…

Occupational exposure to vapors, gasses, dusts, and fumes in relation to causes of death during 24 years in Helsinki, Finland Open

Juuso Jalasto, Ritva Luukkonen, Ari Lindqvist, Arnulf Langhammer, Hannu Kankaanranta , et al. · 2023

Decreasing prevalence of atopic dermatitis in Swedish schoolchildren: three repeated population-based surveys Open

Maja Af Klinteberg, Anna Winberg, Martin Andersson, Eva Rönmark, Linnéa Hedman · 2023

Background The prevalence of atopic dermatitis (AD) has increased over several decades and now affects about one-fifth of all children in high-income countries (HICs). While the increase continues in lower-income countries, the prevalence …

Severity of adult-onset asthma - a matter of blood neutrophils and severe obesity Open

Sofia Winsa‐Lindmark, Caroline Stridsman, Axel Sahlin, Linnéa Hedman, Nikolai Stenfors , et al. · 2023

This study indicates that in adult-onset asthma, primarily non-type-2 characteristics such as obesity and blood neutrophils associate with poor asthma control and higher doses of inhaled corticosteroids.

Phenotyping asthma with airflow obstruction in middle-aged and older adults: a CADSET clinical research collaboration Open

Xander Bertels, Ahmed Edris, Judith García‐Aymerich, Rosa Faner, Howraman Meteran , et al. · 2023

Background The prevalence and clinical profile of asthma with airflow obstruction (AO) remain uncertain. We aimed to phenotype AO in population- and clinic-based cohorts. Methods This cross-sectional multicohort study included adults ≥50 y…

Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 Open

Eva Rönmark, Joakim Bunne, Anders Bjerg, Matthew S. Perzanowski, Anna Winberg , et al. · 2023

The prevalence of allergic sensitization increased from 1996 to 2006 but plateaued in the next decade, whereas the risk factor pattern remained stable. The diverging trends of associations between allergic sensitization and asthma and AR s…

Lung Function Trajectories and Associated Mortality among Adults with and without Airway Obstruction Open

Helena Bäckman, Anders Blomberg, Anders Lundquist, Viktor Strandkvist, Sami Sawalha , et al. · 2023

Rationale: Spirometry is essential for diagnosis and assessment of prognosis in patients with chronic obstructive pulmonary disease (COPD). Objectives: To identify FEV₁ trajectories and their determinants on the ba…

Age-related differences in associations between uncontrolled asthma, comorbidities and biomarkers in adult-onset asthma Open

Katja Warm, Linnéa Hedman, Caroline Stridsman, Anne Lindberg, Eva Rönmark , et al. · 2023

In adult-onset asthma, comorbidities were strongly associated with uncontrolled asthma among older adults, while clinical biomarkers including eosinophils and neutrophils in blood were associated with uncontrolled asthma among middle-aged.

Underdiagnosis and misclassification of COPD in Sweden – A Nordic Epilung study Open

Malin Axelsson, Helena Bäckman, Bright I. Nwaru, Caroline Stridsman, Lowie E.G.W. Vanfleteren , et al. · 2023

Obesity associates with increased all-cause and cardiovascular mortality in adults with asthma Open

Axel Sturesson, Linnéa Hedman, Caroline Stridsman, Anne Lindberg, Eva Rönmark , et al. · 2023

Electronic cigarettes in relation to changes in smoking habits and respiratory symptoms : a population-based cohort study Open

Linnéa Hedman, Gustaf Lyytinen, Helena Bäckman, Magnus Lundbäck, Caroline Stridsman , et al. · 2023

reports of data from original research.• Policy Case Studies -brief articles on policy development at a regional or national level.• Study Protocols -Articles describing a research protocol of a study.• Methodology Papers -Papers that pres…

Interaction of smoking and social status on the risk of respiratory outcomes in a Swedish adult population: A Nordic Epilung study Open

Muwada Bashir Awad Bashir, Rani Basna, Linnéa Hedman, Helena Bäckman, Linda Ekerljung , et al. · 2023

Beyond their independent roles, socioeconomic status and smoking interact in defining the risk of respiratory diseases. Clearer understanding of this interaction can help to identify population subgroups at most need of public health inter…

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