Eva Roth
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View article: P01.07.A ESTABLISHING A SCREENING PLATFORM ON PATIENT-DERIVED ORGANOIDS TO IDENTIFY EFFECTIVE AGENTS TO TREAT GLIOBLASTOMA
P01.07.A ESTABLISHING A SCREENING PLATFORM ON PATIENT-DERIVED ORGANOIDS TO IDENTIFY EFFECTIVE AGENTS TO TREAT GLIOBLASTOMA Open
BACKGROUND Despite aggressive treatments, encompassing surgery, radiotherapy, and chemotherapy, glioblastoma (GBM) presents with poor prognosis and regular recurrence. To improve outcome for recurrent GBM, we established a translational pi…
View article: P02.05.B MAPPING MICROGLIAL DIVERSITY AND TUMOR HETEROGENEITY IN PRIMARY GLIOBLASTOMA AND PATIENT-DERIVED ORGANOIDS
P02.05.B MAPPING MICROGLIAL DIVERSITY AND TUMOR HETEROGENEITY IN PRIMARY GLIOBLASTOMA AND PATIENT-DERIVED ORGANOIDS Open
BACKGROUND Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, marked by extensive inter- and intratumoral heterogeneity and pronounced therapy resistance. Microglia is a major contributor to this complexity…
View article: P18.10.B INTER- AND INTRATUMORAL DRUG RESPONSE HETEROGENEITY IN GLIOBLASTOMA: A COMPARATIVE ORGANOID-BASED ANALYSIS OF TEMOZOLOMIDE AND VORTIOXETINE
P18.10.B INTER- AND INTRATUMORAL DRUG RESPONSE HETEROGENEITY IN GLIOBLASTOMA: A COMPARATIVE ORGANOID-BASED ANALYSIS OF TEMOZOLOMIDE AND VORTIOXETINE Open
BACKGROUND Inter- and intratumoral heterogeneity represents a major obstacle to the effective treatment of glioblastoma (GBM), contributing to therapy resistance and tumor recurrence. Vortioxetine, a multimodal antidepressant, has recently…
View article: A regional computable general equilibrium model for fisheries: results of the EU PECHDEV project
A regional computable general equilibrium model for fisheries: results of the EU PECHDEV project Open
No abstracts are to be cited without prior reference to the author.This paper presents 1-an application of the Computable General Equilibrium (CGE, hereafter) technique to fisheries using data from five EU regions: Bornholm (Denmark), Sale…
View article: Identifying a phenotypic spectrum in FUS-ALS patient-derived fibroblasts
Identifying a phenotypic spectrum in FUS-ALS patient-derived fibroblasts Open
This directory contains data and scripts to reproduce figures reported in: Identifying a phenotypic spectrum in FUS-ALS patient-derived fibroblasts (Kumbier et al. 2023).
View article: Identifying a phenotypic spectrum in FUS-ALS patient-derived fibroblasts
Identifying a phenotypic spectrum in FUS-ALS patient-derived fibroblasts Open
This directory contains data and scripts to reproduce figures reported in: Identifying a phenotypic spectrum in FUS-ALS patient-derived fibroblasts (Kumbier et al. 2023).
View article: Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis
Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis Open
LAT1 supports the regeneration of acinar cells after AP. Female mice lacking LAT1 exhibited more pronounced alterations than male mice, indicating a sexual dimorphism of amino acid metabolism.
View article: Model for leisure boat activities and emissions – implementation for the Baltic Sea
Model for leisure boat activities and emissions – implementation for the Baltic Sea Open
The activities and emissions from leisure boats in the Baltic Sea have been modeled in a comprehensive approach for the first time, using a new simulation model leisure Boat Emissions and Activities siMulator (BEAM). The model utilizes sur…
View article: Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 Open
BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological trans ...
View article: Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015
Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015 Open
BACKGROUND: In September, 2015, the UN General Assembly established the Sustainable Development Goals (SDGs). The SDGs specify 17 universal goals, 169 targets, and 230 indicators leading up to 2030 ...
View article: Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 Open
BACKGROUND: Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological p ...
View article: Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015 Open
BACKGROUND: Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive asses…
View article: Impact of concomitant medication use on belimumab efficacy and safety in patients with systemic lupus erythematosus
Impact of concomitant medication use on belimumab efficacy and safety in patients with systemic lupus erythematosus Open
Practicing physicians have requested efficacy and safety data for belimumab, when used with specific systemic lupus erythematosus (SLE) medications. This was a post hoc analysis of pooled efficacy and safety data from patients who received…
View article: Model for leisure boat activities and emissions – implementation for the Baltic Sea
Model for leisure boat activities and emissions – implementation for the Baltic Sea Open
The activities and emissions from leisure boats at the Baltic Sea have been modelled in a comprehensive approach for the first time, using a new simulation model leisure boat emissions and activities simulator (BEAM). The model utilizes su…
View article: The Cost of Being Unprepared or the Benefit of the Precautionary Principle? Comparing Cost-Benefit COVID-19 Policies and Outcomes in Scandinavia
The Cost of Being Unprepared or the Benefit of the Precautionary Principle? Comparing Cost-Benefit COVID-19 Policies and Outcomes in Scandinavia Open
The Scandinavian countries of Denmark, Iceland, Norway and Sweden have approached the first months of the 2020 novel coronavirus pandemic with a range of economic and health policies that have resulted in disparate outcomes. Though similar…
View article: Smart and Sustainable eMaintenance: Capabilities for Digitalization of Maintenance
Smart and Sustainable eMaintenance: Capabilities for Digitalization of Maintenance Open
In the era of Industry 4.0, researchers have begun to more thoroughly examine digital maintenance, i.e., eMaintenance, as digitization is increasingly affecting today’s society. This area is particularly interesting in the case of long-lif…
View article: Phylogeny of Cimicidae
Phylogeny of Cimicidae Open
Alignment file Chronogramme under different phylogenetic assumptions GBlock alignment tests, Bayesian analysis of individual gene trees, consenus tree, Maximum Likelihood tree
View article: Phylogeny of Cimicidae
Phylogeny of Cimicidae Open
Alignment file Chronogramme under different phylogenetic assumptions GBlock alignment tests, Bayesian analysis of individual gene trees, consenus tree, Maximum Likelihood tree
View article: Biodiversity and ecosystem services in Nordic coastal ecosystems: an IPBES-like assessment. Volume 1. The general overview.
Biodiversity and ecosystem services in Nordic coastal ecosystems: an IPBES-like assessment. Volume 1. The general overview. Open
This report describes the status and trends of biodiversity and ecosystem services in the Nordic region, the drivers and pressures affecting them, interactions and effects on people and society, and options for governance. The main report …
View article: Biodiversity and ecosystem services in Nordic coastal ecosystems
Biodiversity and ecosystem services in Nordic coastal ecosystems Open
This report contributes to a Nordic IPBES-like assessment of biodiversity and ecosystem services in Nordic coastal areas. It is based on ten geographical cases in the Nordic countries (Denmark, Finland, Iceland, Norway, Sweden) and Faroe I…
View article: Biodiversity and ecosystem services in Nordic coastal ecosystems
Biodiversity and ecosystem services in Nordic coastal ecosystems Open
This study has been inspired by the methods and procedures from the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES), to assess and compare information on biodiversity and ecosystem services in Nordi…
View article: Options for governance, institutional arrangements and private and public decision-making across scales and sectors
Options for governance, institutional arrangements and private and public decision-making across scales and sectors Open
This report describes the status and trends of biodiversity and ecosystem services in the Nordic region, the drivers and pressures affecting them, interactions and effects on people and society, an ...
View article: Using labeled choice experiments to analyze demand structure and market position among seafood products
Using labeled choice experiments to analyze demand structure and market position among seafood products Open
Understanding market competition and consumer preferences are important first steps in developing a business. In a competitive market, the effectiveness of the various elements of a firm's marketing mix depends not only on the absolute val…
View article: Preclinical assessment of novel radiopaque UHMWPE sublaminar wires in a growth-guidance system for early onset scoliosis treatment
Preclinical assessment of novel radiopaque UHMWPE sublaminar wires in a growth-guidance system for early onset scoliosis treatment Open
Surgical treatment of scoliosis, a malformation of the vertebral column in children younger than 10 years, is extremely challenging and often requires multiple operations. Reoperations are necessary to enable the vertebral column and chest…
View article: Framing a Nordic IPBES-like study
Framing a Nordic IPBES-like study Open
Natural resource depletion and adverse impacts from environmental degradation, including loss of biodiversity and ecosystem services and their associated knowledge, add to and exacerbate the list of challenges which humanity faces. In orde…