Evaggelia Liaskou
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View article: Regulation of immune responses in primary biliary cholangitis: a transcriptomic analysis of peripheral immune cells
Regulation of immune responses in primary biliary cholangitis: a transcriptomic analysis of peripheral immune cells Open
Background & Aims: In patients with primary biliary cholangitis (PBC), the serum liver biochemistry measured during treatment with ursodeoxycholic acid—the UDCA response—accurately predicts long-term outcome. Molecular characterization of …
View article: Cirrhosis-associated immune dysfunction: Novel insights in impaired adaptive immunity
Cirrhosis-associated immune dysfunction: Novel insights in impaired adaptive immunity Open
The increasing burden faced from complications of cirrhotic liver disease represents a current international public health concern. Regardless of aetiology, patients with cirrhosis are at increased risk of developing a range of life-threat…
View article: Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis
Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis Open
Background & Aims One important hypothesis in primary sclerosing cholangitis pathophysiology suggests that bacterial products from an inflamed leaky gut lead to biliary inflammation. We aimed to investigate whether circulating markers of b…
View article: Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis–Inflammatory Bowel Disease
Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis–Inflammatory Bowel Disease Open
B cells express an antigen‐specific B‐cell receptor (BCR) and may contribute to liver inflammation by recognizing shared antigens in the gut and liver. Herein, we used high‐throughput BCR sequencing of the immunoglobulin heavy chain, speci…
View article: PWE-046 TH17 cells dominate the colonic mucosal immune response in primary sclerosing cholangitis associated colitis
PWE-046 TH17 cells dominate the colonic mucosal immune response in primary sclerosing cholangitis associated colitis Open
Introduction Primary sclerosing cholangitis (PSC) is an idiopathic chronic cholestatic liver disease associated with ulcerative colitis (UC). PSC is thought to be a consequence of a genetically predisposition, dysregulated immune response …
View article: P038 Th17 cells dominate the colonic mucosal immune response in primary sclerosing cholangitis associated colitis
P038 Th17 cells dominate the colonic mucosal immune response in primary sclerosing cholangitis associated colitis Open
Primary sclerosing cholangitis (PSC) is an idiopathic chronic cholestatic liver disease associated with ulcerative colitis (UC). Evidence suggests that PSC is a consequence of an interplay between a dysregulated immune response and unknown…
View article: PTH-102 Association of gut microbiota with mucosal inflammation in ulcerative colitis
PTH-102 Association of gut microbiota with mucosal inflammation in ulcerative colitis Open
Introduction Disturbance in gut microbiota (dysbiosis) is a characteristic feature of ulcerative colitis (UC). It remains unclear whether this dysbiosis contributes to disease pathogenesis by driving immune dysregulation or is merely secon…
View article: MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure Open
Objective Acute liver failure (ALF) is characterised by overwhelming hepatocyte death and liver inflammation with massive infiltration of myeloid cells in necrotic areas. The mechanisms underlying resolution of acute hepatic inflammation a…
View article: Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner
Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner Open
Objective Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of IBD. This clinical association is linked pathologically to the recruitment of mucosal T cells to the liver, via vascular adhesion protein (VAP)-…
View article: Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis
Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis Open
Anti-GP2 IgA can be hypothesised as a novel marker in large bile duct diseases. In particular, in PSC, anti-GP2 IgA identified a subgroup of patients with severe phenotype and poor survival due to cholangiocarcinoma. Anti-GP2 IgA may there…