Evan Austin
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View article: Light-emitting diode red light attenuates epidermal thickening and keratinocyte proliferation in psoriasis models
Light-emitting diode red light attenuates epidermal thickening and keratinocyte proliferation in psoriasis models Open
Psoriasis is an immune-mediated skin condition that impacts approximately 3% of the United States population, with limited adjunctive therapy options. This study investigates the effects of light emitting diode red light (LED-RL) as a pote…
View article: Visible Blue Light Does Not Induce <scp>DNA</scp> Damage in Human Dermal Fibroblasts
Visible Blue Light Does Not Induce <span>DNA</span> Damage in Human Dermal Fibroblasts Open
Photobiomodulation (PBM) is a noninvasive treatment modality that utilizes light to influence cellular activity. PBM has applications in various dermatological conditions. As blue light (BL, 400–500 nm) therapy gains popularity, concerns a…
View article: Mucocutaneous ulcers in an immunocompromised patient
Mucocutaneous ulcers in an immunocompromised patient Open
A 49-year-old female with systemic lupus erythematosus (SLE) on hydroxychloroquine, prednisone, and mycophenolate mofetil presented with 6 months of nonhealing labial and perianal ulcers. On prior inpatient admission, she received acyclovi…
View article: Blue Light Aminolevulinic Acid Photodynamic Therapy Downregulates Cell Division and Proliferation Pathways in Cutaneous Squamous Cell Carcinoma
Blue Light Aminolevulinic Acid Photodynamic Therapy Downregulates Cell Division and Proliferation Pathways in Cutaneous Squamous Cell Carcinoma Open
5-Aminolevulinic (5-ALA) acid photodynamic therapy (PDT) is a treatment for actinic keratosis and has been studied as a treatment for non-invasive cutaneous squamous cell carcinoma (cSCC). PDT induces apoptosis and necrosis in actinic kera…
View article: Visible red light does not induce DNA damage in human dermal fibroblasts
Visible red light does not induce DNA damage in human dermal fibroblasts Open
Visible red light (RL) therapy is a rapidly expanding treatment option for dermatological conditions, including acne, psoriasis and chronic wounds. It is currently unknown if high fluences of RL induce DNA damage via reactive oxygen specie…
View article: Red Light Phototherapy Using Light-Emitting Diodes Inhibits Melanoma Proliferation and Alters Tumor Microenvironments
Red Light Phototherapy Using Light-Emitting Diodes Inhibits Melanoma Proliferation and Alters Tumor Microenvironments Open
Background Total annual cancer rates have decreased due to improved treatment and prevention. However, the incidence of melanoma is rising, and not all patients respond to immune and targeted approaches. Therefore, we sought to determine t…
View article: Transcriptome analysis of human dermal fibroblasts following red light phototherapy
Transcriptome analysis of human dermal fibroblasts following red light phototherapy Open
Fibrosis occurs when collagen deposition and fibroblast proliferation replace healthy tissue. Red light (RL) may improve skin fibrosis via photobiomodulation, the process by which photosensitive chromophores in cells absorb visible or near…
View article: <scp>High‐fluence</scp> light emitting <scp>diode‐red</scp> light inhibits cell cycle progression in human dermal fibroblasts
<span>High‐fluence</span> light emitting <span>diode‐red</span> light inhibits cell cycle progression in human dermal fibroblasts Open
Skin fibrosis is a debilitating feature of several systemic and dermatologic diseases. While current treatment options carry significant risk of side effects and recurrence, high‐fluence light emitting diode‐generated red light (LED‐RL) is…
View article: Facial rejuvenation using photodynamic therapy with a novel preparation of ALA and hyaluronic acid in young adults
Facial rejuvenation using photodynamic therapy with a novel preparation of ALA and hyaluronic acid in young adults Open
Photodynamic therapy (PDT) is a well-established, non-invasive treatment modality that has shown desirable effects such as improvement of fine lines, dyspigmentation, and other signs of photodamage. Many patients seek to decrease, or rever…
View article: Safety of light emitting diode‐red light on human skin: Two randomized controlled trials
Safety of light emitting diode‐red light on human skin: Two randomized controlled trials Open
Therapeutic applications of light emitting diode‐red light (LED‐RL) are expanding, yet data on its clinical effects are lacking. Our goal was to evaluate the safety of high fluence LED‐RL (≥160 J/cm 2 ). In two phase I, single‐blind, dose …
View article: An <em>In Vitro</em> Approach to Photodynamic Therapy
An <em>In Vitro</em> Approach to Photodynamic Therapy Open
Photodynamic therapy (PDT) is a medical procedure that involves incubation of an exogenously applied photosensitizer (PS) followed by visible light photoactivation to induce cell apoptosis. The Federal Drug Administration has approved PDT …
View article: Light‐emitting diodes in dermatology: A systematic review of randomized controlled trials
Light‐emitting diodes in dermatology: A systematic review of randomized controlled trials Open
Objective In dermatology, patient and physician adoption of light‐emitting diode (LED) medical technology continues to grow as research indicates that LEDs may be used to treat skin conditions. The goal of this systematic review is to crit…