Evan C. Lien
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View article: NOTCH3 drives fatty acid oxidation and ferroptosis resistance in aggressive meningiomas
NOTCH3 drives fatty acid oxidation and ferroptosis resistance in aggressive meningiomas Open
Purpose NOTCH3 is increasingly implicated for its oncogenic role in many malignancies, including meningiomas. While prior work has linked NOTCH3 expression to higher-grade meningiomas and treatment resistance, the metabolic phenotype of NO…
View article: An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells
An alternative route for β-hydroxybutyrate metabolism supports cytosolic acetyl-CoA synthesis in cancer cells Open
Cancer cells are exposed to diverse metabolites in the tumour microenvironment that are used to support the synthesis of nucleotides, amino acids and lipids needed for rapid cell proliferation. In some tumours, ketone bodies such as β-hydr…
View article: The glycosyltransferase ALG3 is an AKT substrate that regulates protein N-glycosylation
The glycosyltransferase ALG3 is an AKT substrate that regulates protein N-glycosylation Open
AKT phosphorylates the glycosyltransferase ALG3. The PI3K/AKT signaling pathway is frequently dysregulated in cancer and controls key cellular processes such as survival, proliferation, metabolism, and growth. Protein glycosylation is esse…
View article: NOTCH3 Drives Fatty Acid Oxidation and Ferroptosis Resistance in Aggressive Meningiomas
NOTCH3 Drives Fatty Acid Oxidation and Ferroptosis Resistance in Aggressive Meningiomas Open
PURPOSE NOTCH3 is increasingly implicated for its oncogenic role in many malignancies, including meningiomas. While prior work has linked NOTCH3 expression to higher-grade meningiomas and treatment resistance, the metabolic phenotype of NO…
View article: Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis Open
Nutrient limitation is a characteristic feature of poorly perfused tumors. In contrast to well-perfused tissues, nutrient deficits in tumors perturb cellular metabolic activity, which imposes metabolic constraints on cancer cells. The meta…
View article: Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis Open
Nutrient limitation is a characteristic feature of poorly perfused tumors. In contrast to well-perfused tissues, nutrient deficits in tumors perturb cellular metabolic activity, which imposes metabolic constraints on cancer cells. The meta…
View article: The glycosyltransferase ALG3 is an AKT substrate that regulates protein N-glycosylation
The glycosyltransferase ALG3 is an AKT substrate that regulates protein N-glycosylation Open
The PI3K/AKT signaling pathway is frequently dysregulated in cancer and controls key cellular processes such as survival, proliferation, metabolism and growth. Protein glycosylation is essential for proper protein folding and is also often…
View article: Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis
Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis Open
Nutrient limitation is a characteristic feature of poorly perfused tumors. In contrast to well-perfused tissues, nutrient deficits in tumors perturb cellular metabolic activity, which imposes metabolic constraints on cancer cells. The meta…
View article: Effects of Aging on Glucose and Lipid Metabolism in Mice
Effects of Aging on Glucose and Lipid Metabolism in Mice Open
Aging is accompanied by multiple molecular changes that contribute to aging associated pathologies, such as accumulation of cellular damage and mitochondrial dysfunction. Tissue metabolism can also change with age, in part, because mitocho…
View article: An alternative route for β-hydroxybutyrate metabolism supports fatty acid synthesis in cancer cells
An alternative route for β-hydroxybutyrate metabolism supports fatty acid synthesis in cancer cells Open
Cancer cells are exposed to diverse metabolites in the tumor microenvironment that are used to support the synthesis of nucleotides, amino acids, and lipids needed for rapid cell proliferation 1–3 . Recent work has shown that ketone bodies…
View article: Short-term post-fast refeeding enhances intestinal stemness via polyamines
Short-term post-fast refeeding enhances intestinal stemness via polyamines Open
View article: ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart
ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart Open
Background Metabolic remodeling is a hallmark of the failing heart. Oncometabolic stress during cancer increases the activity and abundance of the ATP-dependent citrate lyase (ACL, Acly ), which promotes histone acetylation and cardiac ada…
View article: The<i>Caenorhabditis elegans</i>bacterial microbiome influences microsporidia infection through nutrient limitation and inhibiting parasite invasion
The<i>Caenorhabditis elegans</i>bacterial microbiome influences microsporidia infection through nutrient limitation and inhibiting parasite invasion Open
Microsporidia are eukaryotic obligate intracellular parasites that infect most animals including humans. To understand how the microbiome can impact microsporidia infection, we tested how bacterial isolates that naturally occur with Caenor…
View article: Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking
Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking Open
Ferroptosis is a form of cell death caused by lipid peroxidation that is emerging as a target for cancer therapy, highlighting the need to identify factors that govern ferroptosis susceptibility. Lipid peroxidation occurs primarily on phos…
View article: A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments Open
Blocking the import of nutrients essential for cancer cell proliferation represents a therapeutic opportunity, but it is unclear which transporters to target. Here we report a CRISPR interference/activation screening platform to systematic…
View article: NF1 deficiency drives metabolic reprogramming in ER+ breast cancer
NF1 deficiency drives metabolic reprogramming in ER+ breast cancer Open
NF1 deficiency drives metabolic reprogramming in ER+ breast cancer. This reprogramming is characterized by oxidative ATP constraints, glutamine TCA influx, and lipid pool expansion, and these metabolic changes introduce novel metabolic-to-…
View article: Effects of aging on glucose and lipid metabolism in mice
Effects of aging on glucose and lipid metabolism in mice Open
Aging is accompanied by multiple molecular changes that contribute to aging-associated pathologies, such as accumulation of cellular damage and mitochondrial dysfunction. Tissue metabolism can also change with age, in part because mitochon…
View article: <i>NF1</i>deficiency drives metabolic reprogramming in ER+ breast cancer
<i>NF1</i>deficiency drives metabolic reprogramming in ER+ breast cancer Open
Objective NF1 is a tumor suppressor gene and its protein product, neurofibromin, is the key negative regulator of the RAS pathway. NF1 is one of the top driver mutations in sporadic breast cancer such that 27% of breast cancers exhibit dam…
View article: Tumor lipid metabolism: a mechanistic link between diet and cancer progression
Tumor lipid metabolism: a mechanistic link between diet and cancer progression Open
View article: A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments Open
Blocking the import of nutrients essential for cancer cell proliferation represents a therapeutic opportunity, but it is unclear which transporters to target. Here, we report a CRISPRi/a screening platform to systematically interrogate the…
View article: Upregulation of Receptor Tyrosine Kinase Activity and Stemness as Resistance Mechanisms to Akt Inhibitors in Breast Cancer
Upregulation of Receptor Tyrosine Kinase Activity and Stemness as Resistance Mechanisms to Akt Inhibitors in Breast Cancer Open
The PI3K/Akt pathway is frequently deregulated in human cancers, and multiple Akt inhibitors are currently under clinical evaluation. Based on the experience from other molecular targeted therapies, however, it is likely that acquired resi…
View article: PI3K drives the de novo synthesis of coenzyme A from vitamin B5
PI3K drives the de novo synthesis of coenzyme A from vitamin B5 Open
In response to hormones and growth factors, the class I phosphoinositide-3-kinase (PI3K) signalling network functions as a major regulator of metabolism and growth, governing cellular nutrient uptake, energy generation, reducing cofactor p…
View article: Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited Open
View article: Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression
Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression Open
Pancreatic ductal adenocarcinoma (PDA) tumor cells are deprived of oxygen and nutrients and therefore must adapt their metabolism to ensure proliferation. In some physiological states, cells rely on ketone bodies to satisfy their metabolic…
View article: Low glycaemic diets alter lipid metabolism to influence tumour growth
Low glycaemic diets alter lipid metabolism to influence tumour growth Open
View article: Pancreatic β cells put the glutamine engine in reverse
Pancreatic β cells put the glutamine engine in reverse Open
View article: REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks
REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks Open
Significance Mutagenic translesion synthesis (TLS) increases cell survival after DNA damage by bypassing lesions that normally block DNA replication but introduces mutations. In cancer cells, REV1/POLζ-dependent mutagenic TLS can contribut…
View article: Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma
Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma Open
Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between cell types within a mixed population can be challenging due to the rapid turnover o…
View article: Author response: Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma
Author response: Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Tumors are composed of many d…
View article: Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited Open
It is not well understood how physiological environmental conditions and nutrient availability influence cancer cell proliferation. Production of oxidized biomass, which requires regeneration of the cofactor NAD+, can limit cancer cell pro…