Evan E. Santo
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View article: Supplementary Figures S1-S5 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Figures S1-S5 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Figures S1-S5 PDF file - 807K, Baseline FACS data to Figure 3b (S1); Total FOXO3a and phosphorylated FOXO3a levels correlate with apoptosis across a cell line panel following MK-2206 treatment (S2); Genes regulated by PI3K/AK…
View article: Supplementary Methods from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Methods from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Methods PDF file - 114K, Includes Lentiviral constructs, Western blotting & Cell fractionation, Luciferase constructs & reporter assay, Cell Viability Assay, Microarray profiling, and TFBS enrichment analysis. Also includes S…
View article: Supplementary Figure and Table Legends from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Figure and Table Legends from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Figure and Table Legends PDF file - 63K, Legend for Supplementary Figures S1-S5 and Supplementary Table S1
View article: Supplementary Table S1 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Table S1 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Table S1 XLS file - 186K, Genes regulated in the SY5Y microarray experiments
View article: Data from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Data from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Neuroblastoma is a pediatric tumor of the peripheral sympathetic nervous system with a highly variable prognosis. Activation of the phosphoinositide 3-kinase (PI3K)/AKT pathway in neuroblastoma is correlated with poor patient prognosis, bu…
View article: Supplementary Methods from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Methods from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Methods PDF file - 114K, Includes Lentiviral constructs, Western blotting & Cell fractionation, Luciferase constructs & reporter assay, Cell Viability Assay, Microarray profiling, and TFBS enrichment analysis. Also includes S…
View article: Supplementary Figure and Table Legends from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Figure and Table Legends from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Figure and Table Legends PDF file - 63K, Legend for Supplementary Figures S1-S5 and Supplementary Table S1
View article: Supplementary Figures S1-S5 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Figures S1-S5 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Figures S1-S5 PDF file - 807K, Baseline FACS data to Figure 3b (S1); Total FOXO3a and phosphorylated FOXO3a levels correlate with apoptosis across a cell line panel following MK-2206 treatment (S2); Genes regulated by PI3K/AK…
View article: Supplementary Table S1 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Table S1 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Table S1 XLS file - 186K, Genes regulated in the SY5Y microarray experiments
View article: Data from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Data from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Neuroblastoma is a pediatric tumor of the peripheral sympathetic nervous system with a highly variable prognosis. Activation of the phosphoinositide 3-kinase (PI3K)/AKT pathway in neuroblastoma is correlated with poor patient prognosis, bu…
View article: <scp>FOXO3A</scp>‐short is a novel regulator of non‐oxidative glucose metabolism associated with human longevity
<span>FOXO3A</span>‐short is a novel regulator of non‐oxidative glucose metabolism associated with human longevity Open
Intronic single‐nucleotide polymorphisms (SNPs) in FOXO3A are associated with human longevity. Currently, it is unclear how these SNPs alter FOXO3A functionality and human physiology, thereby influencing lifespan. Here, we identify a prima…
View article: Near-Complete Genome Sequences of Vesicular Stomatitis Virus Indiana Laboratory Strains HR and T1026R1 and Plaque Isolates 22-20 and 22-25
Near-Complete Genome Sequences of Vesicular Stomatitis Virus Indiana Laboratory Strains HR and T1026R1 and Plaque Isolates 22-20 and 22-25 Open
We report four near-complete genome sequences of vesicular stomatitis virus (VSV) Indiana obtained with Sanger and Illumina next-generation sequencing, namely, laboratory strains HR (heat resistant) and T1026R1 and isolates 22-20 and 22-25…
View article: <scp>FOXO</scp> protects against age‐progressive axonal degeneration
<span>FOXO</span> protects against age‐progressive axonal degeneration Open
Summary Neurodegeneration resulting in cognitive and motor impairment is an inevitable consequence of aging. Little is known about the genetic regulation of this process despite its overriding importance in normal aging. Here, we identify …
View article: High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition
High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition Open
The anti-apoptotic protein B cell lymphoma/leukaemia 2 (BCL-2) is highly expressed in neuroblastoma and plays an important role in oncogenesis. In this study, the selective BCL-2 inhibitor ABT199 was tested in a panel of neuroblastoma cell…
View article: FOXO3a & haematopoietic stem cells: Goodbye PI3K, hello SIRT1?
FOXO3a & haematopoietic stem cells: Goodbye PI3K, hello SIRT1? Open
This article refers to:Evidence for AKT-independent regulation of FOXO1 and FOXO3 in haematopoietic stem and progenitor cells