Evan F. Haney
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View article: A scalable reinforcement learning approach for screening large peptide libraries for bioactive peptide discovery
A scalable reinforcement learning approach for screening large peptide libraries for bioactive peptide discovery Open
Bioactive peptides such as anticancer peptides (ACPs) offer a promising therapeutic alternative to small molecules due to their efficiency and selectivity against tumors and minimal toxicity towards healthy human cells. However, their rati…
View article: Synthetic host defense peptide inhibits SARS-CoV-2 replication <i>in vitro</i>
Synthetic host defense peptide inhibits SARS-CoV-2 replication <i>in vitro</i> Open
Although myriads of potential antiviral agents have been tested against SARS-CoV-2, only a handful have proven to be effective in clinical trials. During the COVID-19 pandemic, many known or novel peptides were evaluated for their ability …
View article: Publisher Correction: A machine learning and centrifugal microfluidics platform for bedside prediction of sepsis
Publisher Correction: A machine learning and centrifugal microfluidics platform for bedside prediction of sepsis Open
View article: A machine learning and centrifugal microfluidics platform for bedside prediction of sepsis
A machine learning and centrifugal microfluidics platform for bedside prediction of sepsis Open
Sepsis is a life-threatening organ dysfunction due to a dysfunctional response to infection. Delays in diagnosis have substantial impact on survival. Herein, blood samples from 586 in-house patients with suspected sepsis are used in conjun…
View article: D-enantiomeric antibiofilm peptides effective against anaerobic <i>Cutibacterium acnes</i> biofilm
D-enantiomeric antibiofilm peptides effective against anaerobic <i>Cutibacterium acnes</i> biofilm Open
The emergence of antibiotic resistance, biofilm formation, and internalization by host cells contribute to a high risk of chronic infections, highlighting the necessity to develop novel therapeutic strategies. Identification of natural hos…
View article: The Use of DeepQSAR Models for The Discovery of Peptides with Enhanced Antimicrobial and Antibiofilm Potential
The Use of DeepQSAR Models for The Discovery of Peptides with Enhanced Antimicrobial and Antibiofilm Potential Open
Increasing concerns regarding prolonged antibiotic usage have spurred the search for alternative treatments. Antimicrobial peptides (AMPs), first discovered in the 1980s, have exhibited significant potential against a broad range of bacter…
View article: Design of highly potent anti-biofilm, antimicrobial peptides using explainable artificial intelligence
Design of highly potent anti-biofilm, antimicrobial peptides using explainable artificial intelligence Open
Antimicrobial peptides have emerged as a potential alternative to traditional small molecule antibiotics. They possess broad-spectrum efficacy and increasingly confront the challenges of bacterial resistance, especially the adaptive resist…
View article: Antibiofilm peptides enhance the corrosion resistance of titanium in the presence of Streptococcus mutans
Antibiofilm peptides enhance the corrosion resistance of titanium in the presence of Streptococcus mutans Open
Titanium alloys have gained popularity in implant dentistry for the restoration of missing teeth and related hard tissues because of their biocompatibility and enhanced strength. However, titanium corrosion and infection caused by microbia…
View article: Efficient in planta production of amidated antimicrobial peptides that are active against drug-resistant ESKAPE pathogens
Efficient in planta production of amidated antimicrobial peptides that are active against drug-resistant ESKAPE pathogens Open
Antimicrobial peptides (AMPs) are promising next-generation antibiotics that can be used to combat drug-resistant pathogens. However, the high cost involved in AMP synthesis and their short plasma half-life render their clinical translatio…
View article: Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens
Novel Alligator Cathelicidin As-CATH8 Demonstrates Anti-Infective Activity against Clinically Relevant and Crocodylian Bacterial Pathogens Open
Host defense peptides (HDPs) represent an alternative way to address the emergence of antibiotic resistance. Crocodylians are interesting species for the study of these molecules because of their potent immune system, which confers high re…
View article: Host Response of Human Epidermis to Methicillin-Resistant Staphylococcus aureus Biofilm Infection and Synthetic Antibiofilm Peptide Treatment
Host Response of Human Epidermis to Methicillin-Resistant Staphylococcus aureus Biofilm Infection and Synthetic Antibiofilm Peptide Treatment Open
Bacterial biofilm infections associated with wounded skin are prevalent, recalcitrant, and in urgent need of treatments. Additionally, host responses in the skin to biofilm infections are not well understood. Here we employed a human organ…
View article: Assessing the Activity of Antimicrobial Peptides Against Common Marine Bacteria Located in Rotifer (Brachionus plicatilis) Cultures
Assessing the Activity of Antimicrobial Peptides Against Common Marine Bacteria Located in Rotifer (Brachionus plicatilis) Cultures Open
Rotifers are used as the first feed for marine fish larvae and are grown in large cultures that have high loads of organic matter and heterotrophic bacteria; these bacteria are passed on to the developing fish larvae and can potentially le…
View article: Addressing Antibiotic Failure—Beyond Genetically Encoded Antimicrobial Resistance
Addressing Antibiotic Failure—Beyond Genetically Encoded Antimicrobial Resistance Open
Antibiotic failure can be defined as any clinical situation where treatment with antibiotics fails to cure the patient and remove the infection. Genetically-determined antibiotic resistance certainly contributes to antibiotic failure in th…
View article: Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures
Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures Open
Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for dentistry. Here, different scaffolds were tested for use during the pulp revascularization process, inc…
View article: Human organoid biofilm model for assessing antibiofilm activity of novel agents
Human organoid biofilm model for assessing antibiofilm activity of novel agents Open
View article: Cathelicidin Host Defense Peptides and Inflammatory Signaling: Striking a Balance
Cathelicidin Host Defense Peptides and Inflammatory Signaling: Striking a Balance Open
Host-defense peptides (HDPs) are vital components of innate immunity in all vertebrates. While their antibacterial activity toward bacterial cells was the original focus for research, their ability to modulate immune and inflammatory proce…
View article: EcDBS1R6: A novel cationic antimicrobial peptide derived from a signal peptide sequence
EcDBS1R6: A novel cationic antimicrobial peptide derived from a signal peptide sequence Open
View article: EcDBS1R6: A new broad-spectrum cationic antibacterial peptide derived from a signal peptide sequence
EcDBS1R6: A new broad-spectrum cationic antibacterial peptide derived from a signal peptide sequence Open
Bacterial infections represent a major worldwide health problem, with an special highlight on Gram-negative bacteria, which were assigned by the World Health Organization (WHO) as the most critical priority for development of novel antimic…
View article: Reassessing the Host Defense Peptide Landscape
Reassessing the Host Defense Peptide Landscape Open
Current research has demonstrated that small cationic amphipathic peptides have strong potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and anti-inflammatories. Although traditionally termed antimicr…
View article: Bone Environment Influences Irreversible Adhesion of a Methicillin-Susceptible Staphylococcus aureus Strain
Bone Environment Influences Irreversible Adhesion of a Methicillin-Susceptible Staphylococcus aureus Strain Open
Prosthesis and joint infections are an important threat in public health, especially due to the development of bacterial biofilms and their high resistance to antimicrobials. Biofilm-associated infections increase mortality and morbidity r…
View article: Critical Assessment of Methods to Quantify Biofilm Growth and Evaluate Antibiofilm Activity of Host Defence Peptides
Critical Assessment of Methods to Quantify Biofilm Growth and Evaluate Antibiofilm Activity of Host Defence Peptides Open
Biofilms are multicellular communities of bacteria that can adhere to virtually any surface. Bacterial biofilms are clinically relevant, as they are responsible for up to two-thirds of hospital acquired infections and contribute to chronic…
View article: In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design
In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design Open
View article: Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms
Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms Open
View article: Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides
Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides Open
View article: Anticancer activities of bovine and human lactoferricin-derived peptides
Anticancer activities of bovine and human lactoferricin-derived peptides Open
Lactoferrin (LF) is a mammalian host defense glycoprotein with diverse biological activities. Peptides derived from the cationic region of LF possess cytotoxic activity against cancer cells in vitro and in vivo. Bovine lactoferricin (LFcin…
View article: An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities
An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities Open
View article: An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities
An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities Open
View article: Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma
Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma Open
View article: A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells
A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells Open
Cationic antimicrobial peptides ( AMP s) possess fast and broad‐spectrum activity against both Gram‐negative and Gram‐positive bacteria, as well as fungi. It has become increasingly evident that many AMP s, including those that derive from…
View article: High throughput screening methods for assessing antibiofilm and immunomodulatory activities of synthetic peptides
High throughput screening methods for assessing antibiofilm and immunomodulatory activities of synthetic peptides Open