Evan H. Phillips
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View article: Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia
Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia Open
Cachexia is the wasting of skeletal muscle in cancer and is a major complication that impacts a person’s quality of life. We hypothesized that cachexia is mediated by dysfunction of the vascular system, which is essential for maintaining p…
View article: Increased Multiplexity in Optical Tissue Clearing-Based Three-Dimensional Immunofluorescence Microscopy of the Tumor Microenvironment by Light-Emitting Diode Photobleaching
Increased Multiplexity in Optical Tissue Clearing-Based Three-Dimensional Immunofluorescence Microscopy of the Tumor Microenvironment by Light-Emitting Diode Photobleaching Open
Optical tissue clearing and three-dimensional (3D) immunofluorescence (IF) microscopy is transforming imaging of the complex tumor microenvironment (TME). However, current 3D IF microscopy has restricted multiplexity; only 3 or 4 cellular …
View article: Increased multiplexity in optical tissue clearing-based 3D immunofluorescence microscopy of the tumor microenvironment by LED photobleaching
Increased multiplexity in optical tissue clearing-based 3D immunofluorescence microscopy of the tumor microenvironment by LED photobleaching Open
Optical tissue clearing and three-dimensional (3D) immunofluorescence (IF) microscopy have been transforming imaging of the complex tumor microenvironment (TME). However, current 3D IF microscopy has restricted multiplexity; only three or …
View article: Three‐dimensional spatial quantitative analysis of cardiac lymphatics in the mouse heart
Three‐dimensional spatial quantitative analysis of cardiac lymphatics in the mouse heart Open
Objective Three‐dimensional (3D) microscopy and image data analysis are necessary for studying the morphology of cardiac lymphatic vessels (LyVs) and their association with other cell types. We aimed to develop a methodology for 3D multipl…
View article: Longitudinal Investigation of Aortic Dissection in Mice with Computational Fluid Dynamics
Longitudinal Investigation of Aortic Dissection in Mice with Computational Fluid Dynamics Open
Patients with aortic dissection require lifelong surveillance to monitor disease progression and detect late adverse events such as aneurysmal dilation, malperfusion or refractory pain. The variety and complexity of aortic dissection have …
View article: Multiresolution 3D Optical Mapping of Immune Cell Infiltrates in Mouse Asthmatic Lung
Multiresolution 3D Optical Mapping of Immune Cell Infiltrates in Mouse Asthmatic Lung Open
Asthma is a chronic inflammatory airway disease driven by various infiltrating immune cell types into the lung. Optical microscopy has been used to study immune infiltrates in asthmatic lungs. Confocal laser scanning microscopy (CLSM) iden…
View article: Three-dimensional spatial quantitative analysis of cardiac lymphatics in the mouse heart
Three-dimensional spatial quantitative analysis of cardiac lymphatics in the mouse heart Open
Objective 3D microscopy and image data analysis are necessary for studying the morphology of cardiac lymphatic vessels (LyVs) and association with other cell types. We aimed to develop a methodology for 3D multiplexed lightsheet microscopy…
View article: Neglected Maritime Terrain in the Bay of Bengal: An Examination of the Future of the Andaman and Nicobar Islands
Neglected Maritime Terrain in the Bay of Bengal: An Examination of the Future of the Andaman and Nicobar Islands Open
The Andaman and Nicobar Islands (ANI) are some of the most neglected maritime terrain in the world despite their proximity to one of the busiest maritime chokepoints on Earth. Strategic competition in the Bay of Bengal and around the Strai…
View article: LIGHT enhanced bispecific antibody armed T-cells to treat immunotherapy resistant colon cancer
LIGHT enhanced bispecific antibody armed T-cells to treat immunotherapy resistant colon cancer Open
Increased tumor infiltrating lymphocytes (TIL) are associated with improved patient responses to immunotherapy. As a result, there is interest in enhancing lymphocyte trafficking particularly to colon cancers since the majority are checkpo…
View article: Multiplexed Tissue Tomography
Multiplexed Tissue Tomography Open
View article: Multimodality Imaging-Based Characterization of Regional Material Properties in a Murine Model of Aortic Dissection
Multimodality Imaging-Based Characterization of Regional Material Properties in a Murine Model of Aortic Dissection Open
View article: Molecular phenotyping and image-guided surgical treatment of melanoma using spectrally distinct ultrasmall core-shell silica nanoparticles
Molecular phenotyping and image-guided surgical treatment of melanoma using spectrally distinct ultrasmall core-shell silica nanoparticles Open
Spectrally distinct ultrasmall fluorescence silica particles as multiplexing tools address cancer heterogeneity and aid surgery.
View article: Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans
Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans Open
Reduced lower-limb blood flow has been shown to lead to asymmetrical abdominal aortic aneurysms (AAAs) but the mechanism of action is not fully understood. Therefore, small animal ultrasound (Vevo2100, FUJIFILM VisualSonics) was used to lo…
View article: Early pathological characterization of murine dissecting abdominal aortic aneurysms
Early pathological characterization of murine dissecting abdominal aortic aneurysms Open
We report here on the early pathology of a well-established murine model of dissecting abdominal aortic aneurysms (AAAs). Continuous infusion of angiotensin II (AngII) into apolipoprotein E-deficient mice induces the formation of aortic di…
View article: B fibers are the best predictors of cardiac activity during Vagus nerve stimulation
B fibers are the best predictors of cardiac activity during Vagus nerve stimulation Open
View article: Development and growth trends in angiotensin II-induced murine dissecting abdominal aortic aneurysms
Development and growth trends in angiotensin II-induced murine dissecting abdominal aortic aneurysms Open
Abdominal aortic aneurysms are pathological dilations that can suddenly rupture, causing more than 15,000 deaths in the U.S. annually. Current treatment focuses on observation until an aneurysm's size warrants surgical intervention. Thus, …
View article: Criminal Convictions, Incarceration, and the Right to Vote in South Carolina
Criminal Convictions, Incarceration, and the Right to Vote in South Carolina Open
View article: Conference Calendar
Conference Calendar Open
View article: Angiotensin II Infusion Does Not Cause Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Rats
Angiotensin II Infusion Does Not Cause Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Rats Open
The apolipoprotein E-deficient (apoE-/-) mouse model has advanced our understanding of cardiovascular disease mechanisms and experimental therapeutics. This spontaneous model recapitulates aspects of human atherosc…
View article: Melanocortin-1 Receptor-Targeting Ultrasmall Silica Nanoparticles for Dual-Modality Human Melanoma Imaging
Melanocortin-1 Receptor-Targeting Ultrasmall Silica Nanoparticles for Dual-Modality Human Melanoma Imaging Open
The poor prognosis associated with malignant melanoma has not changed substantially over the past 30 years. Targeted molecular therapies, such as immunotherapy, have shown promise but suffer from resistance and off-target toxicities, under…
View article: Cancer-Targeting Ultrasmall Silica Nanoparticles for Clinical Translation: Physicochemical Structure and Biological Property Correlations
Cancer-Targeting Ultrasmall Silica Nanoparticles for Clinical Translation: Physicochemical Structure and Biological Property Correlations Open
Although a large body of literature exists on the potential use of nanoparticles for medical applications, the number of probes translated into human clinical trials is remarkably small. A major challenge of particle probe development and …
View article: <i>In Vivo</i> Multiscale and Spatially-Dependent Biomechanics Reveals Differential Strain Transfer Hierarchy in Skeletal Muscle
<i>In Vivo</i> Multiscale and Spatially-Dependent Biomechanics Reveals Differential Strain Transfer Hierarchy in Skeletal Muscle Open
Biological tissues have a complex hierarchical architecture that spans organ to subcellular scales and comprises interconnected biophysical and biochemical machinery. Mechanotransduction, gene regulation, gene protection, and structure-fun…
View article: Multi-Modality Imaging Enables Detailed Hemodynamic Simulations in Dissecting Aneurysms in Mice
Multi-Modality Imaging Enables Detailed Hemodynamic Simulations in Dissecting Aneurysms in Mice Open
A multi-modality imaging-based modeling approach was used to study complex unsteady hemodynamics and lesion growth in a dissecting abdominal aortic aneurysm model. We combined in vivo ultrasound (geometry and flow) and in vitro optical coh…
View article: In vivo photoacoustic lipid imaging in mice using the second near-infrared window
In vivo photoacoustic lipid imaging in mice using the second near-infrared window Open
Photoacoustic imaging has emerged as a promising technique to improve preclinical and clinical imaging by providing users with label-free optical contrast of tissue. Here, we present a proof-of-concept study for noninvasive in vivo …
View article: In Vivo Analysis Of Angiotensin II-Induced Hypertension And Vascular Disease In Rats
In Vivo Analysis Of Angiotensin II-Induced Hypertension And Vascular Disease In Rats Open
Murine models of abdominal aortic aneurysms (AAA) are commonly used to study the pathogenesis of this disease. Rats are often used in laboratory studies because of their size and because they are more physiologically similar to humans than…
View article: Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves
Bond-selective photoacoustic imaging by converting molecular vibration into acoustic waves Open
View article: Imaging of Small Animal Peripheral Artery Disease Models: Recent Advancements and Translational Potential
Imaging of Small Animal Peripheral Artery Disease Models: Recent Advancements and Translational Potential Open
Peripheral artery disease (PAD) is a broad disorder encompassing multiple forms of arterial disease outside of the heart. As such, PAD development is a multifactorial process with a variety of manifestations. For example, aneurysms are pat…
View article: Label‐free <i>in vivo</i> imaging of peripheral nerve by multispectral photoacoustic tomography
Label‐free <i>in vivo</i> imaging of peripheral nerve by multispectral photoacoustic tomography Open
Unintentional surgical damage to nerves is mainly due to poor visualization of nerve tissue relative to adjacent structures. Multispectral photoacoustic tomography can provide chemical information with specificity and ultrasonic spatial re…
View article: Morphological and Biomechanical Differences in the Elastase and AngII<i>apoE</i><sup><i>−/−</i></sup>Rodent Models of Abdominal Aortic Aneurysms
Morphological and Biomechanical Differences in the Elastase and AngII<i>apoE</i><sup><i>−/−</i></sup>Rodent Models of Abdominal Aortic Aneurysms Open
An abdominal aortic aneurysm (AAA) is a potentially fatal cardiovascular disease with multifactorial development and progression. Two preclinical models of the disease (elastase perfusion and angiotensin II infusion in apolipoprotein-E-def…