Explanipedia

Spatiotemporal patterns in malignant brain and central nervous system cancer incidence and mortality in the United States Open

G. Bryce Christensen, Evan L. Thacker, Chantel Sloan-Aagard · 2025

Further research should investigate reasons for the sex and state differences in brain cancer incidence and mortality rates and how regional factors contribute to survival.

Label-Guided Imputation via Forest-Based Proximities for Improved Time Series Classification Open

Jake S. Rhodes, Adam G. Rustad, Sofia Maia, Evan L. Thacker, Hyunmi Choi , et al. · 2025

Missing data is a common problem in time series data. Most methods for imputation ignore label information pertaining to the time series even if that information exists. In this paper, we provide a framework for missing data imputation in …

Knowledge about polycystic ovary syndrome (PCOS), body image and depression by PCOS status among a sample of US females Open

Brianna M. Magnusson, Mireya C. Long, Ruth J. Larson, Lexi Maycock, Emma Wood , et al. · 2025

This study adds to the relatively small body of research on PCOS conducted among US females and highlights that knowledge about PCOS in US young adult females is low, regardless of PCOS status.

Association of COVID-19 stimulus receipt and spending with family health Open

Emma M. Reese, Noah Lines, Evan L. Thacker, Michael Barnes · 2025

In this study, we aimed to determine the impact of U.S. government stimulus payments on family health during the COVID-19 pandemic. We hypothesized that receiving stimulus checks is associated with better family health and the effect of st…

Comorbidity Prevalence in Prediabetes and Type 2 Diabetes: A Cross-Sectional Study in a Predominantly Hispanic U.S.–Mexico Border Population Open

R Noriega, Juan Nañez, Emily Hartmann, John D. Beard, Chantel D. Sloan-Aagard , et al. · 2025

Type 2 diabetes and prediabetes are associated with a higher risk of several health conditions. We conducted a cross-sectional study to compare the prevalence of comorbidities among 88,724 adults with prediabetes and 12,071 adults with typ…

Education Levels and Poststroke Cognitive Trajectories Open

Mellanie V. Springer, Rachael T. Whitney, Wen Ye, Emily M. Briceño, Alden L. Gross , et al. · 2025

Importance Acute stroke is associated with accelerated, years-long cognitive decline. Whether education levels are associated with faster cognitive decline after stroke is unclear. Objective To evaluate the association of education level w…

Levels of procoagulant factors and peak thrombin generation in relation to dementia risk in older adults: The Cardiovascular Health Study Open

Laura B. Harrington, Alexa Ehlert, Evan L. Thacker, Nancy S. Jenny, Oscar L. López , et al. · 2025

Levels of procoagulant factors and peak thrombin generation in relation to dementia risk in older adults: The Cardiovascular Health Study Open

Laura B. Harrington, Alexa Ehlert, Evan L. Thacker, Nancy S. Jenny, Oscar L. López , et al. · 2024

2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association Open

Seth S. Martin, Aaron W. Aday, Zaid Almarzooq, Cheryl A.M. Anderson, Pankaj Arora , et al. · 2024

BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core heal…

Hospital-Acquired Infection at Time of Stroke and Cognitive Decline: The Cardiovascular Health Study Open

Kyril L. Cole, Amelia K. Boehme, Evan L. Thacker, W.T. Longstreth, Bruce L. Brown , et al. · 2023

Introduction: Hospital-acquired infections (HAIs) after stroke are associated with additional morbidity and mortality, but whether HAIs increase long-term cognitive decline in stroke patients is unknown. We hypothesized that …

Circulating Omega-3 and Omega-6 Fatty Acids, Cognitive Decline, and Dementia in Older Adults Open

Marcia C. de Oliveira Otto, Jason Wu, Evan L. Thacker, Heidi Lai, Rozenn N. Lemaître , et al. · 2023

Background: Comprising nearly 35% of brain lipids, polyunsaturated fatty acids (PUFA) are essential for optimal brain function. However, the role of PUFA on cognitive health outcomes later in life is largely unknown. Objective: We investig…

Epilepsy, Vascular Risk Factors, and Cognitive Decline in Older Adults Open

Hyunmi Choi, Mitchell S.V. Elkind, W.T. Longstreth, Amelia K. Boehme, Rebekah Hafen , et al. · 2022

Associations of some VRFs with cognitive decline in older adults are stronger in the presence of epilepsy, suggesting a need for greater attention to vascular protection for preserving brain health in older adults with epilepsy.

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association Open

Connie W. Tsao, Aaron W. Aday, Zaid Almarzooq, Álvaro Alonso, Andrea Beaton , et al. · 2022

Background: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health beh…

Hemostatic factor levels and cognitive decline in older adults: The Cardiovascular Health Study Open

Laura B. Harrington, Alexa Ehlert, Evan L. Thacker, Nancy S. Jenny, Oscar L. López , et al. · 2021

Cognitive decline in older adults with epilepsy: The Cardiovascular Health Study Open

Hyunmi Choi, Evan L. Thacker, W.T. Longstreth, Mitchell S.V. Elkind, Amelia K. Boehme · 2020

Objective Cognitive decline is a major concern for older adults with epilepsy. Whether and how much faster older adults with epilepsy experience cognitive decline beyond expected age‐related cognitive change remain unclear. We sought to es…

Toxoplasma gondii seropositivity and serointensity and cognitive function in adults Open

Shawn D. Gale, Lance D. Erickson, Evan L. Thacker, Elizabeth L. Mitchell, Bruce L. Brown , et al. · 2020

Infecting approximately one-third of the world's human population, Toxoplasma gondii has been associated with cognitive function. Here, we sought to further characterize the association between Toxoplasma gondii and cognitive function in a…

Incident prolonged QT interval in midlife and late-life cognitive performance Open

Cláudia Kimie Suemoto, Laura E. Gibbons, Evan L. Thacker, Jonathan Jackson, Claudia L. Satizábal , et al. · 2020

Although many midlife cardiovascular risk factors and cardiac structure and function measures are associated with late-life cognitive decline, incident prolonged QT interval in midlife was not associated with late-life cognitive performanc…

Cognitive Decline in Older Adults After Incident Coronary Heart Disease or After First Receipt of CABG Surgery or PCI Open

Jacqueline Kunzelman, Evan L. Thacker, Rachel Gabor, Monica Scrobotovici, Natalie J. Blades , et al. · 2020

Cardiovascular health and disease are important determinants of cognitive decline Population-based longitudinal studies of this issue are needed \nHypotheses: Incident CHD leads to faster long-term cognitive decline in older adults Among o…

Cardiovascular factors moderate the association of infection burden with cognitive function in young to middle-aged U.S. adults Open

William O. Dawson, Andrew N. Berrett, Lance D. Erickson, Bruce L. Brown, Evan L. Thacker , et al. · 2019

Participants at zero risk for a cardiovascular event in the next 10 years had no differences in processing speed with increasing exposure to infectious disease, whereas participants with higher risk for a cardiovascular event had worse pro…

Transitions From Heart Disease to Cancer as the Leading Cause of Death in US States, 1999–2016 Open

Michael C. Harding, Chantel Sloan, Ray M. Merrill, Tiffany M. Harding, Brian J Thacker , et al. · 2018

State-level data indicated heterogeneity across US states in the predominance of heart disease mortality relative to cancer mortality. Timing and magnitude of transitions toward cancer mortality predominance varied by state.

SUCCESSFUL AGING: CROSS-CULTURAL COMPARISON OF OLDER ADULTS’ LAY PERSPECTIVES Open

Alfred C. Jensen, Kelsie D. Claunch, Marco A. Verdeja, Matthew T. Dungan, Michael C. Goates , et al. · 2018

Biomedical views of successful aging include physiological, psychological and social constructs, but do not capture older adults’ lay perspectives, and omit culture-specific concepts. Therefore, our objective was to determine how older adu…

Toxoplasma gondii seropositivity and substance use in US adults Open

Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Evan L. Thacker, Bruce L. Brown , et al. · 2018

The intracellular parasite Toxoplasma gondii (Nicolle et Manceaux, 1908) infects humans resulting in acute toxoplasmosis, an infection that in immunocompetent people is typically mild but results in persistent latent toxoplasmosis. In that…

Hemostasis biomarkers and incident cognitive impairment: the REGARDS study Open

Sarah Gillett, Leslie A. McClure, Peter Callas, Evan L. Thacker, Fred Unverzagt , et al. · 2018

Atrial Cardiopathy and the Risk of Ischemic Stroke in the CHS (Cardiovascular Health Study) Open

Hooman Kamel, Traci M. Bartz, Mitchell S.V. Elkind, Peter M. Okin, Evan L. Thacker , et al. · 2018

Background and Purpose— Emerging evidence suggests that an underlying atrial cardiopathy may result in thromboembolism before atrial fibrillation (AF) develops. We examined the association between various markers of atrial cardiopathy and …

Long-Term Cognitive Decline After Newly Diagnosed Heart Failure Open

Christa A. Hammond, Natalie J. Blades, Sarwat I. Chaudhry, John A. Dodson, W.T. Longstreth , et al. · 2018

Background: Heart failure (HF) is associated with cognitive impairment. However, we know little about the time course of cognitive change after HF diagnosis, the importance of comorbid atrial fibrillation, or the role of ejection fraction.…

Toxoplasma gondii seropositivity and substance use in US adults: Raw data files for NHANES III and Continuous NHANES Open

Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Evan L. Thacker, Bruce L. Brown , et al. · 2018

See attached Data Description document for a description of the contents of each data file.

Administrative billing codes accurately identified occurrence of electrical cardioversion and ablation/maze procedures in a prospective cohort study of atrial fibrillation patients Open

Alexa Ehlert, Susan R. Heckbert, Kerri L. Wiggins, Evan L. Thacker · 2017

Background Administrative billing codes for electrical cardioversion and ablation/maze procedures may be useful for atrial fibrillation (AF) research if the codes are accurate relative to medical record documentation. Hypothesis Administra…

Usefulness of the American Heart Association's Life Simple 7 to Predict the Risk of Atrial Fibrillation (from the REasons for Geographic And Racial Differences in Stroke [REGARDS] Study) Open

Parveen K. Garg, Wesley T. O’Neal, Adedotun Ogunsua, Evan L. Thacker, George Howard , et al. · 2017

WHAT IS SUCCESSFUL AGING? COMPARING FRAMEWORKS FOR SUCCESSFUL AGING WITH CULTURAL PERSPECTIVES Open

Anne Louise Jensen, Matthew T. Dungan, Michael C. Goates, Evan L. Thacker · 2017

“Successful aging” has different meanings in different cultures. Our purpose was to examine whether published frameworks for successful aging would align with the values and perspectives of older adults across cultures. We identified studi…

Coronary Artery Bypass Graft Surgery and Dementia Risk in the Cardiovascular Health Study Open

Elżbieta Kuźma, Jac Airdrie, Thomas J. Littlejohns, Ilianna Lourida, Jo Thompson Coon , et al. · 2017

Introduction: The association between history of coronary artery bypass graft surgery (CABG) and dementia risk remains unclear. Methods: We conducted a prospective cohort analysis using data on 3155 elderly adults free from prevalent demen…

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