Evan Masutani
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View article: Characteristics of left ventricular dysfunction in repaired tetralogy of Fallot: A multi-institutional deep learning analysis of regional strain and dyssynchrony
Characteristics of left ventricular dysfunction in repaired tetralogy of Fallot: A multi-institutional deep learning analysis of regional strain and dyssynchrony Open
Patients with rTOF demonstrate four unique patterns of LV dysfunction. Most commonly, but not exclusively, LV dysfunction is characterized by septal wall motion abnormalities and severely reduced septal strain. Patients with this pattern o…
View article: Vinculin Haploinsufficiency Impairs Integrin-Mediated Costamere Remodeling to Changing Microenvironments
Vinculin Haploinsufficiency Impairs Integrin-Mediated Costamere Remodeling to Changing Microenvironments Open
View article: Heterogeneous expression of alternatively spliced lncRNA mediates vascular smooth cell plasticity
Heterogeneous expression of alternatively spliced lncRNA mediates vascular smooth cell plasticity Open
9p21.3 locus polymorphisms have the strongest correlation with coronary artery disease, but as a noncoding locus, disease connection is enigmatic. The lncRNA ANRIL found in 9p21.3 may regulate vascular smooth muscle cell (VSMC) phenotype t…
View article: Deep learning phase error correction for cerebrovascular 4D flow MRI
Deep learning phase error correction for cerebrovascular 4D flow MRI Open
Background phase errors in 4D Flow MRI may negatively impact blood flow quantification. In this study, we assessed their impact on cerebrovascular flow volume measurements, evaluated the benefit of manual image-based correction, and assess…
View article: Deep Learning Synthetic Strain: Quantitative Assessment of Regional Myocardial Wall Motion at MRI
Deep Learning Synthetic Strain: Quantitative Assessment of Regional Myocardial Wall Motion at MRI Open
The deep learning algorithm had comparable performance with subspecialty radiologists in inferring myocardial velocity from cine SSFP images and identifying myocardial wall motion abnormalities at rest in patients with ischemic heart disea…
View article: Deep Learning Phase Error Correction for Cerebrovascular 4D Flow MRI
Deep Learning Phase Error Correction for Cerebrovascular 4D Flow MRI Open
Background and Purpose Background phase errors in 4D Flow MRI may negatively impact blood flow quantification. In this study, we assessed their impact on cerebrovascular flow volume measurements, evaluated the benefit of manual image-based…
View article: Radiologist-supervised Transfer Learning: Improving Radiographic Localization of Pneumonia and Prognostication of Patients With COVID-19.
Radiologist-supervised Transfer Learning: Improving Radiographic Localization of Pneumonia and Prognostication of Patients With COVID-19. Open
Radiologist-supervised transfer learning can enhance the ability of CNNs to localize and quantify the severity of disease. Closed-loop systems incorporating radiologists may be beneficial for continued improvement of artificial intelligenc…
View article: Deep Learning Automated Background Phase Error Correction for Abdominopelvic 4D Flow MRI
Deep Learning Automated Background Phase Error Correction for Abdominopelvic 4D Flow MRI Open
Background Four-dimensional (4D) flow MRI has the potential to provide hemodynamic insights for a variety of abdominopelvic vascular diseases, but its clinical utility is currently impaired by background phase error, which can be challengi…
View article: High shear stress enhances endothelial permeability in the presence of the risk haplotype at 9p21.3
High shear stress enhances endothelial permeability in the presence of the risk haplotype at 9p21.3 Open
Single nucleotide polymorphisms (SNPs) are exceedingly common in non-coding loci, and while they are significantly associated with a myriad of diseases, their specific impact on cellular dysfunction remains unclear. Here, we show that when…
View article: Clinical Performance and Role of Expert Supervision of Deep Learning for Cardiac Ventricular Volumetry: A Validation Study
Clinical Performance and Role of Expert Supervision of Deep Learning for Cardiac Ventricular Volumetry: A Validation Study Open
Fully automated ventricular segmentation by the tested algorithm provides contours and ventricular volumes that could be used to aid expert segmentation, but can benefit from expert supervision, particularly to resolve errors at the basal …
View article: Deep Learning Single-Frame and Multiframe Super-Resolution for Cardiac MRI
Deep Learning Single-Frame and Multiframe Super-Resolution for Cardiac MRI Open
Background Cardiac MRI is limited by long acquisition times, yet faster acquisition of smaller-matrix images reduces spatial detail. Deep learning (DL) might enable both faster acquisition and higher spatial detail via super-resolution. Pu…
View article: 4D Flow Vorticity Visualization Predicts Regions of Quantitative Flow Inconsistency for Optimal Blood Flow Measurement
4D Flow Vorticity Visualization Predicts Regions of Quantitative Flow Inconsistency for Optimal Blood Flow Measurement Open
Cardiac output and blood flow are essential MRI measurements in the evaluation of structural heart disease. Vorticity visualization may be used to help guide optimal location for flow quantification.© RSNA, 2020See also the commentary by M…
View article: Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease
Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease Open
X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia (XMEN) disease are caused by deficiency of the magnesium transporter 1 (MAGT1) gene. We studied 23 patients with XMEN, 8 of whom were EBV naive. We observed lymp…
View article: Deep Learning–based Prescription of Cardiac MRI Planes
Deep Learning–based Prescription of Cardiac MRI Planes Open
DL-based anatomic localization is a feasible strategy for planning cardiac MRI planes. This approach can produce imaging planes comparable to those defined by ground truth landmarks.© RSNA, 2019 Supplemental material is available for th…
View article: Magnesium transporter 1 (MAGT1) deficiency causes selective defects in N-linked glycosylation and expression of immune-response genes
Magnesium transporter 1 (MAGT1) deficiency causes selective defects in N-linked glycosylation and expression of immune-response genes Open
View article: Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming
Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming Open
Lower vertebrate and neonatal mammalian hearts exhibit the remarkable capacity to regenerate through the reprogramming of pre-existing cardiomyocytes. However, how cardiac injury initiates signaling pathways controlling this regenerative r…
View article: Author response: Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming
Author response: Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming Open
View article: Volumetric segmentation‐free method for rapid visualization of vascular wall shear stress using 4D flow MRI
Volumetric segmentation‐free method for rapid visualization of vascular wall shear stress using 4D flow MRI Open
Purpose To develop a rapid segmentation‐free method to visualize and compute wall shear stress (WSS) throughout the aorta using 4D Flow MRI data. WSS is the drag force‐per‐area the vessel endothelium exerts on luminal blood; abnormal level…
View article: Recurrent rhinovirus infections in a child with inherited MDA5 deficiency
Recurrent rhinovirus infections in a child with inherited MDA5 deficiency Open
MDA5 is a cytosolic sensor of double-stranded RNA (ds)RNA including viral byproducts and intermediates. We studied a child with life-threatening, recurrent respiratory tract infections, caused by viruses including human rhinovirus (HRV), i…
View article: The effect of microbial colonization on the host proteome varies by gastrointestinal location
The effect of microbial colonization on the host proteome varies by gastrointestinal location Open
Endogenous intestinal microbiota have wide-ranging and largely uncharacterized effects on host physiology. Here, we used reverse-phase liquid chromatography-coupled tandem mass spectrometry to define the mouse intestinal proteome in the st…