Evan N. Smith
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View article: Filling in the gap: Hippocampal CA1 neuronal counts and volumes in female cognitive controls
Filling in the gap: Hippocampal CA1 neuronal counts and volumes in female cognitive controls Open
CA1 is a subfield in the human hippocampus that is particularly vulnerable to hypoxia. Previous stereological studies on CA1 have examined primarily male samples, leaving female total neuron counts not represented or underrepresented in to…
View article: TARP ɣ-8 is a target of ethanol that regulates self-administration and relapse in mice
TARP ɣ-8 is a target of ethanol that regulates self-administration and relapse in mice Open
Background Behavioral pathologies that characterize alcohol use disorder (AUD) are driven by the powerful reinforcing, or rewarding, properties of the drug. We have shown that glutamate AMPA receptor (AMPAR) activity is both necessary and …
View article: Locus coeruleus tau validates and informs high-resolution MRI in aging and at earliest Alzheimer’s pathology stages
Locus coeruleus tau validates and informs high-resolution MRI in aging and at earliest Alzheimer’s pathology stages Open
View article: Negative modulation of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner in male mice
Negative modulation of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner in male mice Open
View article: Inhibition of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 (TARP γ-8) blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner
Inhibition of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 (TARP γ-8) blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner Open
Rationale The development and progression of alcohol use disorder (AUD) is widely viewed as maladaptive neuroplasticity. The transmembrane alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) regulatory protein γ8 (TA…
View article: Alcohol Drinking Exacerbates Neural and Behavioral Pathology in the 3xTg-AD Mouse Model of Alzheimer’s Disease
Alcohol Drinking Exacerbates Neural and Behavioral Pathology in the 3xTg-AD Mouse Model of Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that represents the most common cause of dementia in the United States. Although the link between alcohol use and AD has been studied, preclinical research has potential …
View article: The Calgary Brain Bank
The Calgary Brain Bank Open
With the financial assistance from two donors, we have established a neurodegenerative disease brain bank at the University of Calgary. At autopsy, tissues from anatomically specific regions are frozen in liquid nitrogen vapour and stored …