Evan P. Troendle
YOU?
Author Swipe
View article: 3D electron microscopy reveals novel ultrastructural changes in the diabetic retinal neurovascular unit
3D electron microscopy reveals novel ultrastructural changes in the diabetic retinal neurovascular unit Open
View article: Scavenging acrolein with 2-HDP preserves neurovascular integrity in a rat model of diabetic retinal disease
Scavenging acrolein with 2-HDP preserves neurovascular integrity in a rat model of diabetic retinal disease Open
View article: Combining analysis of individual and wastewater whole genome sequencing improves SARS-CoV-2 surveillance
Combining analysis of individual and wastewater whole genome sequencing improves SARS-CoV-2 surveillance Open
Effective pathogen surveillance is critical for public health decision-making, with both individual and environmental monitoring playing essential roles. While wastewater (WW) and individual whole genome sequencing (WGS) have been used to …
View article: Permeability Benchmarking: Guidelines for Comparing <i>in Silico</i>, <i>in Vitro</i>, and <i>in Vivo</i> Measurements
Permeability Benchmarking: Guidelines for Comparing <i>in Silico</i>, <i>in Vitro</i>, and <i>in Vivo</i> Measurements Open
Permeability is a measure of the degree to which cells can transport molecules across biological barriers. Units of permeability are distance per unit time (typically cm/s), where accurate measurements are needed to define drug delivery in…
View article: Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Nav1.6 complex in nucleus accumbens neurons
Enhanced motivated behavior mediated by pharmacological targeting of the FGF14/Nav1.6 complex in nucleus accumbens neurons Open
View article: SARS-CoV-2 introductions to the island of Ireland: a phylogenetic and geospatiotemporal study of infection dynamics
SARS-CoV-2 introductions to the island of Ireland: a phylogenetic and geospatiotemporal study of infection dynamics Open
View article: Wastewater monitoring of human and avian influenza A viruses in Northern Ireland: a genomic surveillance study
Wastewater monitoring of human and avian influenza A viruses in Northern Ireland: a genomic surveillance study Open
Department of Health for Northern Ireland.
View article: A least-squares-fitting procedure for an efficient preclinical ranking of passive transport across the blood–brain barrier endothelium
A least-squares-fitting procedure for an efficient preclinical ranking of passive transport across the blood–brain barrier endothelium Open
View article: SARS-CoV-2 introductions to the island of Ireland
SARS-CoV-2 introductions to the island of Ireland Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had an unprecedented impact on the people of Ireland as waves of infection spread across the island during the global coronavirus disease 2019 (COVID-19) pandemic. Viral whol…
View article: Geometrically reconstructing confocal microscopy images for modelling the retinal microvasculature as a 3D cylindrical network
Geometrically reconstructing confocal microscopy images for modelling the retinal microvasculature as a 3D cylindrical network Open
Microvascular networks can be modelled as a network of connected cylinders. Presently, however, there are limited approaches with which to recover these networks from biomedical images. We have therefore developed and implemented computer …
View article: Investigation of heterocellular features of the mouse retinal neurovascular unit by 3D electron microscopy
Investigation of heterocellular features of the mouse retinal neurovascular unit by 3D electron microscopy Open
The retina has a complex structure with a diverse collection of component cells that work together to facilitate vision. The retinal capillaries supplying the nutritional requirements to the inner retina have an intricate system of neural,…
View article: The Role of Lipoxidation in the Pathogenesis of Diabetic Retinopathy
The Role of Lipoxidation in the Pathogenesis of Diabetic Retinopathy Open
Lipids can undergo modification as a result of interaction with reactive oxygen species (ROS). For example, lipid peroxidation results in the production of a wide variety of highly reactive aldehyde species which can drive a range of disea…
View article: An experimentally validated approach to calculate the blood-brain barrier permeability of small molecules
An experimentally validated approach to calculate the blood-brain barrier permeability of small molecules Open
Drug development for the treatment of central nervous system (CNS) diseases is extremely challenging, in large part due to the difficulty in crossing the blood-brain barrier (BBB). Here we develop and experimentally validate a new in silic…
View article: Simulation-Guided Rational <i>de Novo</i> Design of a Small Pore-Forming Antimicrobial Peptide
Simulation-Guided Rational <i>de Novo</i> Design of a Small Pore-Forming Antimicrobial Peptide Open
In the age of failing small-molecule antibiotics, tapping the near-infinite structural and chemical repertoire of antimicrobial peptides (AMPs) offers one of the most promising routes toward developing next-generation antibacterial compoun…
View article: Predicting drug delivery efficiency into tumor tissues through molecular simulation of transport in complex vascular networks
Predicting drug delivery efficiency into tumor tissues through molecular simulation of transport in complex vascular networks Open
View article: Predicting Drug Delivery Efficiency into Tumor Tissues through Molecular Simulation of Transport in Complex Vascular Networks
Predicting Drug Delivery Efficiency into Tumor Tissues through Molecular Simulation of Transport in Complex Vascular Networks Open