Explanipedia

Adaptation to ex vivo culture reduces human hematopoietic stem cell activity independently of the cell cycle Open

Carys Johnson, Matthew Williams, Kendig Sham, Serena Belluschi, Wenjuan Ma , et al. · 2024

Loss of long-term hematopoietic stem cell (LT-HSC) function ex vivo hampers the success of clinical protocols that rely on culture. However, the kinetics and mechanisms through which this occurs remain incompletely characterized. In this s…

The Nucleosome Remodelling and Deacetylation complex coordinates the transcriptional response to lineage commitment in pluripotent cells Open

Bertille Montibus, Ramy Ragheb, Evangelia Diamanti, Sara‐Jane Dunn, Nicola Reynolds , et al. · 2023

As cells exit the pluripotent state and begin to commit to a specific lineage they must activate genes appropriate for that lineage while silencing genes associated with pluripotency and preventing activation of lineage-inappropriate genes…

The Nucleosome Remodelling and Deacetylation complex coordinates the transcriptional response to lineage commitment in pluripotent cells Open

Bertille Montibus, Ramy Ragheb, Evangelia Diamanti, Sara‐Jane Dunn, Nicola Reynolds , et al. · 2023

As cells exit the pluripotent state and begin to commit to a specific lineage they must activate genes appropriate for that lineage while silencing genes associated with pluripotency and preventing activation of lineage-inappropriate genes…

Adaptation to<i>ex vivo</i>culture drives human haematopoietic stem cell loss of repopulation capacity in a cell cycle independent manner Open

Carys Johnson, Kendig Sham, Serena Belluschi, Xiaonan Wang, Winnie Lau , et al. · 2022

Loss of long-term haematopoietic stem cell function (LT-HSC) hampers the success of ex vivo HSC gene therapy and expansion procedures, but the kinetics and the mechanisms by which this occurs remain incompletely characterized. Here through…

Endothelial-specific Gata3 expression is required for hematopoietic stem cell generation Open

Nada Zaidan, Leslie Nitsche, Evangelia Diamanti, Rebecca Hannah, A Fidanza , et al. · 2022

To generate sufficient numbers of transplantable hematopoietic stem cells (HSCs) in vitro, a detailed understanding of how this process takes place in vivo is essential. The endothelial-to-hematopoietic transition (EHT), which culminates i…

Anti-IgE-gerichtete Therapie der Urtikaria in der dermatologischen Praxis Open

Evangelia Diamanti, Julia Föhr, Andria Papageorgiou, Matthias Herbst, Sigbert Jahn · 2022

Zosterimpfung unter Biologikatherapie Open

Sigbert Jahn, Evangelia Diamanti, Tatjana Heller, Antria Papageorgiou, Matthias Herbst · 2021

Endothelial-specific Gata3 expression is required for haematopoietic stem cell generation Open

Nada Zaidan, Evangelia Diamanti, Leslie Nitsche, A Fidanza, Nicola K. Wilson , et al. · 2021

To generate sufficient numbers of transplantable haematopoietic stem cells (HSCs) in vitro , a detailed understanding of how this process takes place in vivo is essential. The endothelial-to-haematopoietic transition (EHT), which culminate…

Therapie der atopischen Dermatitis mit Dupilumab Open

Sigbert Jahn, Julia Föhr, Evangelia Diamanti, Matthias Herbst · 2021

Einsatz von Biologika in der dermatologischen Praxis Open

Sigbert Jahn, Matthias Herbst, Evangelia Diamanti · 2021

Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures Open

Caroline A. Oedekoven, Miriam Belmonte, Daniel Bode, Fiona Hamey, Mairi Shepherd , et al. · 2021

Advances in the isolation and gene expression profiling of single hematopoietic stem cells (HSCs) have permitted in-depth resolution of their molecular program. However, long-term HSCs can only be isolated to near purity from adult mouse b…

Therapie der atopischen Dermatitis mit Dupilumab: Eine retrospektive Kohortenanalyse aus der dermatologischen Praxis Open

Sigbert Jahn, Julia Föhr, Evangelia Diamanti, Matthias Herbst · 2021

Single‐cell molecular profiling provides a high‐resolution map of basophil and mast cell development Open

Fiona Hamey, Winnie Lau, Iwo Kuciński, Xiaonan Wang, Evangelia Diamanti , et al. · 2020

Background Basophils and mast cells contribute to the development of allergic reactions. Whereas these mature effector cells are extensively studied, the differentiation trajectories from hematopoietic progenitors to basophils and mast cel…

Single-cell molecular profiling provides a high-resolution map of basophil and mast cell differentiation Open

Fiona Hamey, Winnie Lau, Iwo Kuciński, Xiaonan Wang, Evangelia Diamanti , et al. · 2019

Differentiation of hematopoietic stem and progenitor cells ensure a continuous supply of mature blood cells. Recent models of differentiation are represented as a landscape, in which individual progenitors traverse a continuum of multipote…

Expanded potential stem cell media as a tool to study human developmental hematopoiesis in vitro Open

Adam C. Wilkinson, David Ryan, Iwo Kuciński, Wei Wang, Jian Yang , et al. · 2019

Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency Open

Tüzer Kalkan, Susanne Bornelöv, Carla Mulas, Evangelia Diamanti, Tim Lohoff , et al. · 2019

Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors Open

Serena Belluschi, Emily F. Calderbank, Valerio Ciaurro, Blanca Pijuan-Sala, Antonella Santoro , et al. · 2018

A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice Open

Joakim S. Dahlin, Fiona Hamey, Blanca Pijuan-Sala, Mairi Shepherd, Winnie Lau , et al. · 2018

Key Points Single-cell transcriptional landscape of 44 802 hematopoietic stem/progenitor cells defines entry points to 8 different blood lineages. Comparison with 13 815 c-Kit mutant cells identifies pleiotropic changes in cell type abunda…

A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation Open

Sonia Nestorowa, Fiona Hamey, Blanca Pijuan-Sala, Evangelia Diamanti, Mairi Shepherd , et al. · 2016

Key Points An expression map of HSPC differentiation from single-cell RNA sequencing of HSPCs provides insights into blood stem cell differentiation. A user-friendly Web resource provides access to single-cell gene expression profiles for …

Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells Open

Tiago Faial, Andreia S. Bernardo, Sasha Mendjan, Evangelia Diamanti, Daniel Ortmann , et al. · 2015

The transcription factor brachyury (T, BRA) is one of the first markers of gastrulation and lineage specification in vertebrates. Despite its wide use and importance in stem cell and developmental biology, its functional genomic targets in…

Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations Open

Nicola K. Wilson, David G. Kent, Florian Buettner, Mona Shehata, Iain C. Macaulay , et al. · 2015

Decoding the regulatory network of early blood development from single-cell gene expression measurements Open

Victoria Moignard, Steven Woodhouse, Laleh Haghverdi, Andrew J. Lilly, Yosuke Tanaka , et al. · 2015

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