Explanipedia

Advanced machine learning techniques for coronary artery disease risk prediction in early middle-aged adults Open

Efrat Monsonego‐Ornan, Eran Feldhay, Εvangelos Εvangelou · 2025

Measurement error correction methods for the effects of ambient air pollution on mortality and morbidity using the UK Biobank cohort: the MELONS study Open

Dimitris Evangelopoulos, D. L. Wood, Barbara K. Butland, Benjamin Barratt, Hanbin Zhang , et al. · 2025

Epidemiological cohort studies associating long-term exposure to ambient air pollution with health outcomes most often do not account for individually assigned exposure measurement error. Here, we implemented Cox proportional hazards model…

Multi-trait association analysis reveals shared genetic loci between Alzheimer’s disease and cardiovascular traits Open

Fotios Koskeridis, Nurun Fancy, Pei Fang Tan, Devendra Meena, Εvangelos Εvangelou , et al. · 2024

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits Open

Jacob M. Keaton, Zoha Kamali, Tian Xie, Ahmad Vaez, Ariel Williams , et al. · 2024

Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure Open

Mahboube Ganji-Arjenaki, Zoha Kamali, Εvangelos Εvangelou, Helen R. Warren, He Gao , et al. · 2024

Our findings provide a solid basis for follow-up studies to further identify genes and mechanisms in myofibroblast cells that underlie the regulation of BP.

Pleiotropic effects of PLEC and C1Q on Alzheimer’s disease and cardiovascular traits Open

Fotios Koskeridis, Nurun Fancy, Pei Fang Tan, Εvangelos Εvangelou, Devendra Meena , et al. · 2024

Several cardiovascular (CV) traits and diseases co-occur with Alzheimer’s disease (AD). We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 1…

Omalizumab for the Treatment of Allergic Rhinitis: A Systematic Review and Meta-Analysis Open

Sophia Tsabouri, Georgios Ntritsos, Fotios Koskeridis, Εvangelos Εvangelou, Petter Olsson , et al. · 2024

Background: Allergic rhinitis (AR), an IgE-mediated inflammatory disease, significantly impacts the quality of life of a considerable proportion of the general population. Omalizumab, a humanized monoclonal antibody against IgE, has been e…

Interactions of obesity, body shape, diabetes and sex steroids with respect to prostate cancer risk in the UK Biobank cohort Open

Sofia Christakoudi, Konstantinos K. Tsilidis, Εvangelos Εvangelou, Elio Ríboli · 2024

Background Obesity and diabetes are associated inversely with low‐grade prostate cancer risk and affect steroid hormone synthesis but whether they modify each other's impact on prostate cancer risk remains unknown. Methods We examined the …

Risk factors for preterm birth: an umbrella review of meta-analyses of observational studies Open

Ioannis Mitrogiannis, Εvangelos Εvangelou, Athina Efthymiou, Theofilos Kanavos, Effrosyni Birbas , et al. · 2023

Multiple long-term conditions in people with psoriasis: a latent class and bidirectional Mendelian randomization analysis Open

Christos V. Chalitsios, Devendra Meena, Maria Manou, Christos Papagiannopoulos, Georgios Markozannes , et al. · 2023

Background Coexisting long-term conditions (LTCs) in psoriasis and their potential causal associations with the disease are not well established. Objectives To determine distinct clusters of LTCs in people with psoriasis and the potential…

Interactions of platelets with obesity in relation to lung cancer risk in the UK Biobank cohort Open

Sofia Christakoudi, Konstantinos K. Tsilidis, Εvangelos Εvangelou, Elio Ríboli · 2023

Background Platelet count (PLT) is associated positively with lung cancer risk but has a more complex association with body mass index (BMI), positive only in women (mainly never smokers) and inverse in men (mainly ever smokers), raising t…

Appraising the Causal Role of Risk Factors in Coronary Artery Disease and Stroke: A Systematic Review of Mendelian Randomization Studies Open

Andrea Georgiou, Loukas Zagkos, Georgios Markozannes, Christos V. Chalitsios, Alexandros‐Georgios Asimakopoulos , et al. · 2023

BACKGROUND Mendelian randomization (MR) offers a powerful approach to study potential causal associations between exposures and health outcomes by using genetic variants associated with an exposure as instrumental variables. In this system…

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification Open

Vasiliki Lagou, Longda Jiang, Anna Ulrich, Liudmila Zudina, Karla Sofia Gutiérrez González , et al. · 2023

Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on ‘around the clock’ glucoregulatory processes. Here we show t…

Association of Blood MicroRNA Expression and Polymorphisms with Cognitive and Biomarker Changes in Older Adults Open

Angélique Sadlon, Petros Takousis, Εvangelos Εvangelou, Inga Prokopenko, Panagiotis Alexopoulos , et al. · 2023

six miRNAs may serve as potential blood biomarker of subclinical cognitive deficits in AD. Polymorphisms within these miRNAs suggest a possible interplay between the amyloid cascade and microglial activation at preclinical stages of AD.

Associations of obesity and body shape with erythrocyte and reticulocyte parameters in the UK Biobank cohort Open

Sofia Christakoudi, Konstantinos K. Tsilidis, Εvangelos Εvangelou, Elio Ríboli · 2023

A novel polygenic risk score model based on the protein interactions: An application on psoriasis Open

Charalabos Antonatos, Fotios Koskeridis, Christiana M. Ralliou, Yiannis Vasilopoulos, Εvangelos Εvangelou · 2023

Background Polygenic Risk Scores (PRS) have been widely applied for predicting an individual’s genetic risk to a phenotype. Here, we develop a biologically-driven PRS in the UK BioBank cohort through validated protein interactions (PPI) an…

Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure Open

Mateusz Siedliński, Lorenzo Carnevale, Xiaoguang Xu, Daniela Carnevale, Εvangelos Εvangelou , et al. · 2023

Background and aims Observational studies have linked elevated blood pressure (BP) to impaired cognitive function. However, the functional and structural changes in the brain that mediate the relationship between BP elevation and cognitive…

Risk factors for preterm labor: An Umbrella Review of meta-analyses of observational studies Open

Ioannis Mitrogiannis, Εvangelos Εvangelou, Athina Efthymiou, Theofilos Kanavos, Effrosyni Birbas , et al. · 2023

Preterm birth defined as delivery before 37 gestational weeks, is a leading cause of neonatal and infant morbidity and mortality. Understanding its multifactorial nature may improve prediction, prevention and the clinical management. We pe…

Correlation of Lymphocyte Subpopulations, Clinical Features and Inflammatory Markers during Severe COVID-19 Onset Open

Angelos Liontos, Alexandros‐Georgios Asimakopoulos, Γεώργιος Μαρκόπουλος, Dimitrios Biros, Lazaros Athanasiou , et al. · 2023

Background: Dysregulation of the immune response in the course of COVID-19 has been implicated in critical outcomes. Lymphopenia is evident in severe cases and has been associated with worse outcomes since the early phases of the pandemic.…

Sex differences in the associations of body size and body shape with platelets in the UK Biobank cohort Open

Sofia Christakoudi, Konstantinos K. Tsilidis, Εvangelos Εvangelou, Elio Ríboli · 2023

Background Obesity is accompanied by low-grade inflammation and leucocytosis and increases the risk of venous thromboembolism. Associations with platelet count, however, are unclear, because several studies have reported positive associati…

Association of patient characteristics with clinical outcomes in a cohort of hospitalised patients with SARS-CoV-2 infection in a Greek referral centre for COVID-19 – Corrigendum Open

Iro Rapti, Alexandros‐Georgios Asimakopoulos, Angelos Liontos, Maria Kosmidou, Eirini Christaki , et al. · 2023

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Mediterranean diet related metabolite profiles and cognitive performance Open

Christopher Papandreou, Christos Papagiannopoulos, Myrto Koutsonida, Afroditi Kanellopoulou, Georgios Markozannes , et al. · 2022

Pleiotropic genetic architecture and novel loci for C-reactive protein levels Open

Fotios Koskeridis, Εvangelos Εvangelou, Saredo Said, Joseph J. Boyle, Paul Elliott , et al. · 2022

Lp(a) is not associated with arterial stiffness: a Mendelian randomization study Open

Alexandros Simistiras, D Delialis, Georgios Georgiopoulos, Dimitrios Bampatsias, Eleni Maneta , et al. · 2022

Background Deeper understanding of the potential causal relationship between Lp(a) and vascular injury will provide further insight to related pathways to be monitored and targeted by emerging treatments. Accumulating evidence supports the…

Mediterranean diet related metabolite profiles and cognitive performance in a Greek population Open

Christopher Papandreou, Christos Papagiannopoulos, Myrto Koutsonida, Afroditi Kanellopoulou, Georgios Markozannes , et al. · 2022

Background Evidence suggests that adherence to the Mediterranean diet (MedDiet) affects human metabolism and may contribute to better cognitive performance. However, the underlying mechanisms are not clear. Objective We generated a metabol…

Health outcomes in primary care: a 20-year evidence map of randomized controlled trials Open

Αριστέα Μίσσιου, Christos Lionis, Εvangelos Εvangelou, Athina Tatsioni · 2022

Objective To quantify the different types of health outcomes assessed as primary outcomes in randomized controlled trials (RCTs) in the primary care (PC) setting during the last 20 years and identify whether potential gaps exist in specifi…

Author Correction: Genetic analysis of over half a million people characterises C-reactive protein loci Open

Saredo Said, Raha Pazoki, Ville Karhunen, Urmo Võsa, Symen Ligthart , et al. · 2022

Associations of body shape phenotypes with sex steroids and their binding proteins in the UK Biobank cohort Open

Sofia Christakoudi, Elio Ríboli, Εvangelos Εvangelou, Konstantinos K. Tsilidis · 2022

Associations of sex steroids and their binding proteins with body shape are unclear, because waist and hip circumference are correlated strongly with body size. We defined body shape using “a body shape index” (ABSI) and hip index (HI), wh…

A multi-omics approach identifies a blood-based miRNA signature of cognitive decline in two large observational trials Open

Angélique Sadlon, Petros Takousis, Εvangelos Εvangelou, Inga Prokopenko, Panagiotis Alexopoulos , et al. · 2022

Identifying individuals before the onset of overt symptoms is a key prerequisite for the prevention of Alzheimer’s disease (AD). A wealth of data reports dysregulated microRNA (miRNA) expression in the blood of individuals with AD, but evi…

Associations of body shape index (ABSI) and hip index with liver, metabolic, and inflammatory biomarkers in the UK Biobank cohort Open

Sofia Christakoudi, Elio Ríboli, Εvangelos Εvangelou, Konstantinos K. Tsilidis · 2022

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