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View article: Vagal nerve stimulation alters task-evoked pupillary responses in older adults but not younger adults in a single-blind sham-controlled crossover trial
Vagal nerve stimulation alters task-evoked pupillary responses in older adults but not younger adults in a single-blind sham-controlled crossover trial Open
Introduction The locus coeruleus (LC) undergoes age-related changes and is involved in Alzheimer’s disease pathogenesis. Vagal nerve stimulation (VNS) may modulate LC activity and could be used therapeutically, but age-related differences …
View article: A leadership ethics curriculum: Bringing mixed-methods interdisciplinary insights to the ethical complexities of health leadership
A leadership ethics curriculum: Bringing mixed-methods interdisciplinary insights to the ethical complexities of health leadership Open
In response to the increasingly complex ethical issues facing health leaders, the Bioethics Department at The Hospital for Sick Children (a Canadian quaternary care paediatric research institution) was asked by senior leadership to develop…
View article: Attention-dependent coupling with forebrain and brainstem neuromodulatory nuclei differs across the lifespan
Attention-dependent coupling with forebrain and brainstem neuromodulatory nuclei differs across the lifespan Open
View article: Age and gender-related patterns of arterial transit time and cerebral blood flow in healthy adults
Age and gender-related patterns of arterial transit time and cerebral blood flow in healthy adults Open
Normal aging has been associated with increased arterial transit time (ATT) and reduced cerebral blood flow (CBF). However, age-related patterns of ATT and CBF and their relationship remain unclear. This is partly due to the lengthy scan t…
View article: Children Use Others’ Talk about Emotions to Make Social Choices
Children Use Others’ Talk about Emotions to Make Social Choices Open
View article: Direct perception of affective valence from vision
Direct perception of affective valence from vision Open
Subjective feelings are thought to arise from conceptual and bodily states. We examine whether the valence of feelings may also be decoded directly from objective ecological statistics of the visual environment. We train a visual valence (…
View article: Attentional priority and limbic activity favor gains over losses
Attentional priority and limbic activity favor gains over losses Open
Prospect theory has suggested that decisions reflect a bias toward avoidance of loss compared to equivalent gains. In our study we examine whether a similar bias is found in decisions regarding whether a loss associated stimulus or a gain …
View article: Taking twelve slow breaths enhances cardiovascular and cognitive plasticity in young and older adults.
Taking twelve slow breaths enhances cardiovascular and cognitive plasticity in young and older adults. Open
Slow controlled breathing is an ancient practice for mental and physiological calm and is often distilled in the present-day advice to ‘take a deep breath.’ However, the effects of slow breathing on cognition and its underlying mechanisms …
View article: Locus coeruleus hyperactivity in middle age may be associated with better cognitive performance
Locus coeruleus hyperactivity in middle age may be associated with better cognitive performance Open
Background Measuring the health of the locus coeruleus (LC), the brainstem site of the first cellular damage in Alzheimer’s Disease (AD) pathogenesis, is of particular interest for early diagnosis. In both rodents and humans (Elman 2017; K…
View article: Locus coeruleus neuromelanin accumulation and dissipation across the lifespan
Locus coeruleus neuromelanin accumulation and dissipation across the lifespan Open
The pigment neuromelanin, produced in the locus coeruleus (LC) as a byproduct of catecholamine synthesis, gives the “blue spot” its name, and both identifies LC neurons and is thought to play an important yet complex role in normal and pat…
View article: Attention-dependent coupling with forebrain and brainstem neuromodulatory nuclei changes across the lifespan
Attention-dependent coupling with forebrain and brainstem neuromodulatory nuclei changes across the lifespan Open
Attentional states continuously reflect the predictability and uncertainty in one’s environment having important consequences for learning and memory. Beyond well known cortical contributions, rapid shifts in attention are hypothesized to …
View article: Direct perception of affective valence from vision
Direct perception of affective valence from vision Open
Affect has been posited as the basic subjective feeling component underlying all experience, arising directly from internal states of the body and the closely related proximal senses. By contrast, in the distal senses such as vision, affec…
View article: Affine image registration of arterial spin labeling MRI using deep learning networks
Affine image registration of arterial spin labeling MRI using deep learning networks Open
Convolutional neural networks (CNN) have demonstrated good accuracy and speed in spatially registering high signal-to-noise ratio (SNR) structural magnetic resonance imaging (sMRI) images. However, some functional magnetic resonance imagin…
View article: Nonlinear changes in pupillary attentional orienting responses across the lifespan
Nonlinear changes in pupillary attentional orienting responses across the lifespan Open
View article: Community research liaison role in increasing participation of African Americans in cognitive research: A case study
Community research liaison role in increasing participation of African Americans in cognitive research: A case study Open
Background Racial and ethnic underrepresentation in aging research and need for effective recruitment strategies is well documented. A Community Research Liaison (CRL) role created under a NIA award is demonstrating the value of embedding …
View article: Locus Coeruleus Bold Activity is Reduced in Older Adults and Associated with Changes in Attention and Memory
Locus Coeruleus Bold Activity is Reduced in Older Adults and Associated with Changes in Attention and Memory Open
View article: Interaction of cholinergic disruption and age on cognitive flexibility in rats
Interaction of cholinergic disruption and age on cognitive flexibility in rats Open
Healthy aging is associated with a functional reduction of the basal forebrain (BF) system that supplies the neurochemical acetylcholine (ACh) to the cortex, and concomitant challenges to cognition. It remains unclear how aging and ACh los…
View article: Wrinkles in subsecond time perception are synchronized to the heart
Wrinkles in subsecond time perception are synchronized to the heart Open
The role of the heart in the experience of time has been long theorized but empirical evidence is scarce. Here we examined the interaction between fine-grained cardiac dynamics and the momentary experience of subsecond intervals. Participa…
View article: Older adults’ views on training tools to prevent cognitive decline
Older adults’ views on training tools to prevent cognitive decline Open
Computerized training platforms could be an accessible means for older adults to maintain cognitive health, and several such tools are already commercially available. However, it remains unclear whether older adults’ use these tools if tra…
View article: Face-to-face learning enhances the social transmission of information
Face-to-face learning enhances the social transmission of information Open
Learning from others provides the foundation for culture and the advancement of knowledge. Learning a new visuospatial skill from others represents a specific challenge—overcoming differences in perspective so that we understand what someo…
View article: Differential color tuning of the mesolimbic reward system
Differential color tuning of the mesolimbic reward system Open
View article: Attention and cardiac phase boost judgments of trust
Attention and cardiac phase boost judgments of trust Open
Fluctuations in mental and bodily states have both been shown to be associated with negative affective experience. Here we examined how momentary fluctuations in attentional and cardiac states combine to regulate the perception of positive…
View article: Differential temporal salience of earning and saving
Differential temporal salience of earning and saving Open
View article: Cholinergic Modulation of Frontoparietal Cortical Network Dynamics Supporting Supramodal Attention
Cholinergic Modulation of Frontoparietal Cortical Network Dynamics Supporting Supramodal Attention Open
A critical function of attention is to support a state of readiness to enhance stimulus detection, independent of stimulus modality. The nucleus basalis magnocellularis (NBM) is the major source of the neurochemical acetylcholine (ACh) for…
View article: Segregation of the human basal forebrain using resting state functional MRI
Segregation of the human basal forebrain using resting state functional MRI Open
The basal forebrain (BF) is poised to play an important neuromodulatory role in brain regions important to cognition due to its broad projections and complex neurochemistry. While significant in vivo work has been done to elaborate BF func…
View article: Functional segregation of the human basal forebrain using resting state neuroimaging
Functional segregation of the human basal forebrain using resting state neuroimaging Open
The basal forebrain (BF) is poised to play an important neuromodulatory role in brain re-gions important to cognition due to its broad projections and complex neurochemistry. While significant in vivo work has been done to elaborate BF fun…
View article: Eve De Rosa Faculty Bio
Eve De Rosa Faculty Bio Open