Explanipedia

Spatial fibroblast niches define Crohn’s fistulae Open

Colleen GC McGregor, Xiao Qin, Tarun Gupta, David Fawkner-Corbett, Esther Bridges , et al. · 2025

Crohn’s disease often presents with fistulae, abnormal tunnels that connect the intestine to the skin or other organs. Despite their profound effect on morbidity, the molecular basis of fistula formation remains unclear, largely owing to t…

AI portal tract detection and characterisation for a regional analysis of steatosis and inflammation in MASLD, MASH and AIH Open

Dylan Windell, Alastair Magness, Cayden Beyer, Helena Thomaides Brears, Sarah J. Larkin , et al. · 2025

Aims Annotation of liver biopsies for disease staging is increasingly aided by digital pathology; however, existing systems do not quantify inflammation and steatosis within an anatomical framework. We hypothesise that an artificial intell…

AI portal tract detection and characterisation for a regional analysis of steatosis and inflammation in MASLD, MASH, and AIH Open

Dylan Windell, Alastair Magness, Cayden Beyer, Helena Thomaides‐Brears, Sarah J. Larkin , et al. · 2025

Background & Aims Annotation of liver biopsies, for disease staging is increasingly aided by digital pathology, however existing systems do not quantify inflammation and steatosis within an anatomical framework. We developed an AI system t…

Tracking in situ checkpoint inhibitor-bound target T cells in patients with checkpoint-induced colitis Open

Tarun Gupta, Agne Antanaviciute, Chloe H. Lee, Rosana Ottakandathil Babu, Anna Aulicino , et al. · 2024

The success of checkpoint inhibitors (CPIs) for cancer has been tempered by immune-related adverse effects including colitis. CPI-induced colitis is hallmarked by expansion of resident mucosal IFNγ cytotoxic CD8⁺ T cells, but ho…

CD, or not CD, that is the question: a digital interobserver agreement study in coeliac disease Open

James Denholm, B.A. Schreiber, Florian Jaeckle, Mike N. Wicks, E W Benbow , et al. · 2024

Objective Coeliac disease (CD) diagnosis generally depends on histological examination of duodenal biopsies. We present the first study analysing the concordance in examination of duodenal biopsies using digitised whole-slide images (WSIs)…

HPB P41 Pitfalls in establishing a preoperative diagnosis; correlating the radiological and histopathological findings of suspected intraductal papillary neoplasm of the bile duct (IPNB) Open

Daniel Hughes, Sanchit Turaga, Alex Gordon‐Weeks, Eve Fryer, Doireann M. McWeeney , et al. · 2022

Background Intraductal papillary neoplasm of the bile duct (IPNB) represents a cohort of uncommon biliary tract tumours. It is commonly unrecognised or misdiagnosed in cross sectional imaging of the liver. This rare tumour is of significan…

P20 Technical advances in imaging guided minimally invasive post-mortem CT angiography Open

Cheng Xie, Tina Mackinnon, Peter Cox, Sheena Thomas, Giacomo Galuppi , et al. · 2022

Objective Post-mortem computed tomography (PMCT) is widely used to reduce the requirement for invasive autopsy. The angiographic aspect of the PMCT has been described in centres in England and Europe using different techniques. This study …

RFID analysis of the complexity of cellular pathology workflow—An opportunity for digital pathology Open

Lisa Browning, Kieron White, Darrin Siiankoski, Richard Colling, Derek Roskell , et al. · 2022

Digital pathology (DP) offers potential for time efficiency gains over an analog workflow however, to date, evidence supporting this claim is relatively lacking. Studies available concentrate on specific workflow points such as diagnostic …

Impact of the transition to digital pathology in a clinical setting on histopathologists in training: experiences and perceived challenges within a UK training region Open

Lisa Browning, Lucinda Winter, Rosalin Cooper, Abhisek Ghosh, Thomas Dytor , et al. · 2022

Aims With increasing utility of digital pathology (DP), it is important to consider the experiences of histopathologists in training, particularly in view of the varied access to DP across a training region and the consequent need to remai…

Interferon-Gamma–Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor–Colitis Open

Sarah C. Sasson, Stephanie Slevin, Vincent Cheung, Isar Nassiri, Anna Olsson‐Brown , et al. · 2021

Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort Open

Kento Imajo, Louise Ann Tetlow, Andrea Dennis, Elizabeth Shumbayawonda, Sofia Mouchti , et al. · 2021

Quantitative mpMRI is an effective alternative to liver biopsy for diagnosing NASH and non-alcoholic fatty liver, and thus may offer clinical utility in patient management.

P298 Checkpoint inhibitor colitis: insights from bench and bedside Open

Tarun Gupta, Agne Antanaviciute, Anna Aulicino, Vincent Cheung, Anna Olsson‐Brown , et al. · 2021

Aims Immune checkpoint blockade (ICB) is the mainstay of treatment for metastatic melanoma and lung adenocarcinoma, and their use is growing in cancer. Immune checkpoint blockade induced colitis (ICB colitis) presents a management challeng…

P257 Real world experience of the new ACR-EULAR classification criteria for IgG4-related disease Open

Rory Peters, Harry Martin, Aleena Virdee, Eve Fryer, Helen Bungay , et al. · 2021

Introduction IgG4-related hepatopancreatobiliary disease (IgG4-HPB) is part of a complex fibro-inflammatory systemic condition. It is critical to distinguish IgG4-HPB from malignant and inflammatory disease mimics to guide long-term manage…

Correspondence on ‘The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease' Open

Rory Peters, Harry Martin, Aleena Virdee, Eve Fryer, Helen Bungay , et al. · 2020

Coronial autopsies identify the indirect effects of COVID-19 Open

Robert Pell, Eve Fryer, Sanjiv Manek, Lucinda Winter, Ian S D Roberts · 2020

A multi-disciplinary approach to igG4 related disease aids in diagnosis and management Open

Rory Peters, George Goodchild, Harry Martin, Tamsin Cargill, Adetokunbo Fadipe , et al. · 2020

Role of digital pathology in diagnostic histopathology in the response to COVID-19: results from a survey of experience in a UK tertiary referral hospital Open

Lisa Browning, Eve Fryer, Derek Roskell, Kieron White, Richard Colling , et al. · 2020

The COVID-19 pandemic has challenged our diagnostic services at a time when many histopathology departments already faced a diminishing workforce and increasing workload. Digital pathology (DP) has been hailed as a potential solution to at…

Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way? Open

Vincent Cheung, Tarun Gupta, Anna Olsson‐Brown, Sreedhar Subramanian, Sarah C. Sasson , et al. · 2020

Background Immune checkpoint inhibitors (ICI) improve survival but cause immune-related adverse events (irAE). We sought to determine if CTCAE classification, IBD biomarkers/endoscopic/histological scores correlate with irAE colitis outcom…

Su1185 IMMUNE CHECKPOINT INHIBITOR-RELATED COLITIS ASSESSMENT AND PROGNOSIS: CAN UCEIS, MAYO AND NANCY INDEX SCORING POINT THE WAY? Open

Vincent Cheung, Tarun Gupta, Anna Olsson‐Brown, Sreedhar Subramanian, Sarah C. Sasson , et al. · 2020

Experience from the first UK inter-regional specialist multidisciplinary meeting in the diagnosis and management of IgG4-related disease Open

George Goodchild, Rory JR Peters, Tamsin Cargill, Harry Martin, Adetokunbo Fadipe , et al. · 2020

Immunoglobulin G4-related disease (IgG4-RD) is a complex multisystem fibro-inflammatory disorder, requiring diagnostic differentiation from malignancy and other immune-mediated conditions, and careful management to minimise glucocorticoid-…

Pulmonary hyalinising granuloma: a rare and elusive cause of multiple lung nodules Open

Ivan Tang, Alastair Moore, Eve Fryer, Annemarie Sykes · 2020

A 72-year-old woman was referred with incidentally detected multiple lung nodules, one of which was identified as 18 F-fluorodeoxyglucose (FDG)-avid on positron emission tomography. Extensive workup followed, including numerous radiographs…

PTU-100 The role of a multi-regional specialist multi-disciplinary meeting in diagnosis and management of igg4-related disease Open

George Goodchild, Rory Peters, Tamsin Cargill, Adetokunbo Fadipe, Maria Leando , et al. · 2019

Introduction IgG4-related disease (IgG4-RD) is a complex multi-system fibroinflammatory disorder, often presenting to the gastroenterologist as autoimmune pancreatitis (AIP) and sclerosing cholangitis (IgG4-SC). It requires careful diagnos…

Lupus causing small bowel obstruction Open

Yunfei Yang, Anne-Marie Bartsch, Eve Fryer, Daniel Hancu · 2018

A 20-year-old female patient was admitted to hospital in 2015 with 1 year history of recurrent abdominal pain, distension, borborygmi and nausea. The patient had a background of systemic lupus erythematous (SLE) diagnosed 4 years before, w…

Exophytic cystic liver lesion: an unusual presentation of a hepatocellular carcinoma in a young female Open

Tom A. Gardiner, David Nasralla, Eve Fryer, Helen Bungay, Michael Silva · 2017

Hepatocellular carcinoma (HCC) is one of the most common malignant primary liver tumours. However, primary hepatic carcinomas are rare in young adults, accounting for approximately 1% of tumours in people below the age of 20. Hepatitis B v…

Interobserver Variability in Histologic Evaluation of Liver Fibrosis Using Categorical and Quantitative Scores Open

Michael Pavlides, Jacqueline Birks, Eve Fryer, David Delaney, Nikita Sarania , et al. · 2017

These results suggest that DIA-CPA is the most robust method for assessing liver fibrosis followed by visual-CPA. Categorical scores perform less well than both the quantitative CPA scores assessed here.

Altered expression of epithelial-to-mesenchymal transition proteins in extraprostatic prostate cancer Open

Clare Verrill, Lucia Cerundolo, Chad M. McKee, Michael J. White, Christiana Kartsonaki , et al. · 2015

Epithelial to mesenchymal transition (EMT) of cancer cells involves loss of epithelial polarity and adhesiveness, and gain of invasive and migratory mesenchymal behaviours. EMT occurs in prostate cancer (PCa) but it is unknown whether this…

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