Evelyn L. Jara
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View article: Critical Role of Iodine and Thyroid Hormones During Pregnancy
Critical Role of Iodine and Thyroid Hormones During Pregnancy Open
Iodine is an essential micronutrient that is required for thyroid hormone (TH) synthesis. However, adequate maternal thyroid function is critical for fetal growth and neurodevelopment. Pregnancy increases iodine requirements due to enhance…
View article: Critical Role of Iodine and Thyroid Hormones During Pregnancy
Critical Role of Iodine and Thyroid Hormones During Pregnancy Open
Iodine is a crucial component of thyroid hormones (THs), specifically triiodothyronine (T3) and thyroxine (T4) and is vital for normal thyroid function. During pregnancy, a deficiency in iodine can result in inadequate production of THs, l…
View article: Female offspring gestated in hypothyroxinemia and infected with human Metapneumovirus (hMPV) suffer a more severe infection and have a higher number of activated CD8+ T lymphocytes
Female offspring gestated in hypothyroxinemia and infected with human Metapneumovirus (hMPV) suffer a more severe infection and have a higher number of activated CD8+ T lymphocytes Open
Maternal thyroid hormones (THs) are essential for the appropriate development of the fetus and especially for the brain. Recently, some studies have shown that THs deficiency can also alter the immune system development of the progeny and …
View article: Therapeutic Potential of Isoflavones with an Emphasis on Daidzein
Therapeutic Potential of Isoflavones with an Emphasis on Daidzein Open
Daidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual‐directional purpose by substituting/hindering with est…
View article: A Mineralocorticoid Receptor Deficiency in Myeloid Cells Reduces Liver Steatosis by Impairing Activation of CD8+ T Cells in a Nonalcoholic Steatohepatitis Mouse Model
A Mineralocorticoid Receptor Deficiency in Myeloid Cells Reduces Liver Steatosis by Impairing Activation of CD8+ T Cells in a Nonalcoholic Steatohepatitis Mouse Model Open
Background and Aims The mineralocorticoid receptor (MR) and renin-angiotensin-aldosterone system (RAAS) are implicated in non-alcoholic liver fatty disease (NALFD). However, inflammatory mechanisms linking MR and RAAS with disease patholog…
View article: Tolerogenic dendritic cell transfer ameliorates systemic lupus erythematosus in mice
Tolerogenic dendritic cell transfer ameliorates systemic lupus erythematosus in mice Open
Summary Current treatments for systemic autoimmune diseases partially improve the health of patients displaying low pharmacological efficacy and systemic immunosuppression. Here, the therapeutic potential of transferring tolerogenic dendri…
View article: Functional Impairment of Mononuclear Phagocyte System by the Human Respiratory Syncytial Virus
Functional Impairment of Mononuclear Phagocyte System by the Human Respiratory Syncytial Virus Open
The mononuclear phagocyte system (MPS) comprises of monocytes, macrophages (MΦ), and dendritic cells (DCs). MPS is part of the first line of immune defense against a wide range of pathogens, including viruses, such as the human respiratory…
View article: Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection
Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection Open
Human Respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are the two major etiological viral agents of lower respiratory tract diseases, affecting mainly infants, young children and the elderly. Although the infection of b…
View article: Hormonal Modulation of Dendritic Cells Differentiation, Maturation and Function: Implications for the Initiation and Progress of Systemic Autoimmunity
Hormonal Modulation of Dendritic Cells Differentiation, Maturation and Function: Implications for the Initiation and Progress of Systemic Autoimmunity Open
Hormonal homeostasis is crucial for keeping a competent and healthy immune function. Several hormones can modulate the function of various immune cells such as dendritic cells (DCs) by influencing the initiation of the immune response and …