Explanipedia

Durable complete response of advanced hepatocellular carcinoma using cannabis oil: a report of two cases Open

Pieter F. van den Berg, Simeon J. S. Ruiter, Jules J.G. Slangen, Derk Jan A. de Groot, Evert van den Broek , et al. · 2025

Genome‐Wide <span>DNA</span> Methylation and Copy Number Alterations in Gastrointestinal Stromal Tumors Open

Tony G. Kleijn, Baptiste Ameline, Roos F. Bleckman, Wierd Kooistra, Evert van den Broek , et al. · 2025

Gastrointestinal stromal tumors (GISTs) span a broad clinical spectrum, from indolent neoplasms to life‐threatening metastatic tumors. A persistent limitation of current risk stratification systems is that a subset of GISTs is graded as lo…

Preoperative Anemia as a Prognostic Risk Factor for Inferior Oncological Survival Following Resection for Pancreatic Ductal Adenocarcinoma Open

Monique M.E.M. Bos, N. Helge Meyer, Allard G Wijma, Karl Khatib-Chahidi, Evert van den Broek , et al. · 2025

Objectives: A significant proportion of patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC) are anemic at the time of resection. In these patients, blood transfusions are omitted because of their potential negative impa…

2202P Large cell neuroendocrine carcinoma (LCNEC) subtyping based on NEUROD1, ASCL1, POU2F3 and YAP1 expression Open

Frank W J Heijboer, Jules L. Derks, Nicole Rijnsburger, B.C.M. Hermans, Lisa M. Hillen , et al. · 2023

The impact of standardized structured reporting of pathology reports for breast cancer care Open

J. A. A. Snoek, Irıs D. Nagtegaal, Sabine Siesling, Evert van den Broek, H.-J. van Slooten , et al. · 2022

We demonstrate that SR has led to more complete pathology reports, which meets the needs for precision of information in breast cancer care. This is expected to improve communication and discussions between specialists regarding parameters…

Molecular pathways in post-colonoscopy versus detected colorectal cancers: results from a nested case–control study Open

Roel Bogie, Chantal M. C. le Clercq, Quirinus J.M. Voorham, Martijn Cordes, Daoud Sie , et al. · 2021

Fusion transcripts and their genomic breakpoints in polyadenylated and ribosomal RNA–minus RNA sequencing data Open

Youri Hoogstrate, Malgorzata A. Komor, René Böttcher, Job van Riet, Harmen J.G. van de Werken , et al. · 2021

Background Fusion genes are typically identified by RNA sequencing (RNA-seq) without elucidating the causal genomic breakpoints. However, non–poly(A)-enriched RNA-seq contains large proportions of intronic reads that also span genomic brea…

Epidermal growth factor receptor targeted fluorescence molecular imaging for postoperative lymph node assessment in patients with oral cancer Open

Jasper Vonk, Jaron G. de Wit, Floris J. Voskuil, Yang Tang, Wouter TR Hooghiemstra , et al. · 2021

In most oral cancer patients, surgical treatment includes resection of the primary tumor combined with excision of lymph nodes (LNs), either for staging or for treatment. All LNs harvested during surgery require tissue processing and subse…

Molecular pathways in post-colonoscopy versus detected colorectal cancers: results from a nested case-control study Open

Roel Bogie, Chantal M. C. le Clercq, Quirinus J.M. Voorham, Martijn Cordes, Daoud Sie , et al. · 2021

Background Post-colonoscopy colorectal cancers (PCCRCs) pose a challenge in clinical practice. PCCRCs occur due to a combination of procedural and biological causes. Specific features of lesions may contribute for this. In a nested case-co…

Detection of fusion transcripts and their genomic breakpoints from RNA sequencing data Open

Youri Hoogstrate, Malgorzata A. Komor, René Böttcher, Job van Riet, Harmen J.G. van de Werken , et al. · 2021

Spliced fusion-transcripts are typically identified by RNA-seq without elucidating the causal genomic breakpoints. However, non poly(A)-enriched RNA-seq contains large proportions of intronic reads spanning also genomic breakpoints. Using …

Prognostic value of microvessel density in stage II and III colon cancer patients: a retrospective cohort study Open

Sjoerd H. den Uil, Evert van den Broek, Veerle M.H. Coupé, Thomas T. Vellinga, Pien M. Delis‐van Diemen , et al. · 2019

MACROD2 expression predicts response to 5-FU-based chemotherapy in stage III colon cancer Open

Evert van den Broek, Sjoerd H. den Uil, Veerle M.H. Coupé, Pien M. Delis‐van Diemen, Anne S. Bolijn , et al. · 2018

These data indicate that low nuclear expression of MACROD2 is associated with poor prognosis of patients with stage III MSS primary colon cancer who were treated with 5-FU-based adjuvant chemotherapy.

Genomic subtypes of pulmonary large cell neuroendocrine carcinoma (LCNEC) may predict chemotherapy outcome Open

Jules L. Derks, Noémie Leblay, Robert Jan van Suylen, Erik Thunnissen, Michael A. den Bakker , et al. · 2017

GeneBreak: detection of recurrent DNA copy number aberration-associated chromosomal breakpoints within genes Open

Evert van den Broek, Stef van Lieshout, Christian Rausch, Bauke Ylstra, Mark A. van de Wiel , et al. · 2017

Development of cancer is driven by somatic alterations, including numerical and structural chromosomal aberrations. Currently, several computational methods are available and are widely applied to detect numerical copy number aberrations (…

Erratum: CFTR is a tumor suppressor gene in murine and human intestinal cancer Open

B L N Than, Janneke F. Linnekamp, Timothy K. Starr, David A. Largaespada, A Rod , et al. · 2017

Chromosomal breakpoints in colorectal cancer Open

Evert van den Broek · 2016

Loss of KCNQ1 expression in stage II and stage III colon cancer is a strong prognostic factor for disease recurrence Open

Sjoerd H. den Uil, Veerle M.H. Coupé, Janneke F. Linnekamp, Evert van den Broek, Jeroen Goos , et al. · 2016

Genomic profiling of stage II and III colon cancers reveals <i>APC</i> mutations to be associated with survival in stage III colon cancer patients Open

Evert van den Broek, Oscar Krijgsman, Daoud Sie, Marianne Tijssen, Sandra Mongera , et al. · 2016

Tumor profiling of DNA alterations, i.e. gene point mutations, somatic copy number aberrations (CNAs) and structural variants (SVs), improves insight into the molecular pathology of cancer and clinical outcome. Here, associations between g…

GeneBreak: detection of recurrent DNA copy number aberration-associated chromosomal breakpoints within genes Open

Evert van den Broek, Stef van Lieshout, Christian Rausch, Bauke Ylstra, Mark A. van de Wiel , et al. · 2016

Development of cancer is driven by somatic alterations, including numerical and structural chromosomal aberrations. Currently, several computational methods are available and are widely applied to detect numerical copy number aberrations (…

CFTR is a tumor suppressor gene in murine and human intestinal cancer Open

B L N Than, Janneke F. Linnekamp, Timothy K. Starr, David A. Largaespada, A Rod , et al. · 2016

High Prevalence and Clinical Relevance of Genes Affected by Chromosomal Breaks in Colorectal Cancer Open

Evert van den Broek, Maurits Dijkstra, Oscar Krijgsman, Daoud Sie, Josien Haan , et al. · 2015

We conclude that CNA-associated chromosomal breaks within genes represent a highly prevalent and clinically relevant subset of SVs in CRC.

Reduced rate of copy number aberrations in mucinous colorectal carcinoma Open

Niek Hugen, Femke Simmer, Leonie J. Mekenkamp, Miriam Koopman, Evert van den Broek , et al. · 2015

Results from this study indicate that the distinct MC phenotype is accompanied by a different genetic basis when compared with AC and show a strong association between the rate of chromosomal instability and survival in MC patients.

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