Evgeny Kiner
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View article: Supplementary Table S5 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S5 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Gene signatures for all 54 de novo discovered PM cNMF modules
View article: Data from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Data from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Immunotherapies have shown great promise in pleural mesothelioma (PM), yet most patients still do not achieve significant clinical response, highlighting the importance of improving the understanding of the tumor microenvironment (TME). He…
View article: Supplementary Figure S6 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S6 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
NK cell IC blockade targeting NKG2A as a novel therapeutic strategy in PM
View article: Supplementary Figure S5 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S5 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Molecular dissection of T cell programs and IC molecules shows association with scS-score
View article: Supplementary Table S4 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S4 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
De novo markers discovered for each detailed cell type annotation in the peripheral blood samples
View article: Supplementary Table S2 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S2 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
De novo markers discovered for each major cell type annotation in tumor samples
View article: Supplementary Figure S2 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S2 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Unbiased discovery of PM cancer programs and association with patient survival
View article: Supplementary Figure S3 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S3 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Fetal-like, cancer-specific PLVAP+ endothelial cells associate with angiogenesis
View article: Supplementary Table S1 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S1 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Patients clinical information
View article: Supplementary Figure S1 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S1 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Single-cell catalogue of PM tumor and PBMC samples
View article: Supplementary Figure S4 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Figure S4 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
Macrophages in scS-high PM express CXCL9/10/11 and likely contribute to T-cell infiltration
View article: Supplementary Table S3 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S3 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
De novo markers discovered for each major cell type annotation in the peripheral blood samples
View article: Supplementary Table S6 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma
Supplementary Table S6 from Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma Open
SCENIC-predicted regulon targets of ETS1 and MEF2C in PM endothelial cells
View article: Single cell view of tumor microenvironment gradients in pleural mesothelioma
Single cell view of tumor microenvironment gradients in pleural mesothelioma Open
Immunotherapies have shown great promise in pleural mesothelioma (PM), yet most patients still do not achieve significant clinical response, highlighting the importance of improving understanding of the tumor microenvironment (TME). Here, …
View article: Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer
Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer Open
View article: 579-C Reinvigoration of progenitor-exhausted CD8 T cells by anti-CTLA-4 contributes to the sustained activity of combination checkpoint blockade
579-C Reinvigoration of progenitor-exhausted CD8 T cells by anti-CTLA-4 contributes to the sustained activity of combination checkpoint blockade Open
Background Combination checkpoint blockade with anti-PD-1 and anti-CTLA-4 antibodies has shown promising efficacy in melanoma. However, the underlying mechanism in humans remains unclear. A better understanding of the cellular and molecula…
View article: Additional file 2 of Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes
Additional file 2 of Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes Open
Additional file 2: Table S1. The composition of each of the 6 cell mixtures, based on cell counts, compared to estimates based on flow cytometry and scRNA-seq analysis.
View article: Additional file 5 of Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes
Additional file 5 of Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes Open
Additional file 5: Table S4. Datasets used to evaluate deconvolution accuracy. Annotations include methods for setting the gold-standard composition, quality of deconvolution, sample types, cell or nuclei counts, UMI counts, and the number…
View article: Reinvigoration of Progenitor-Exhausted CD8 T Cells by anti-CTLA-4 Contributes to the Sustained Activity of Combination Checkpoint Blockade
Reinvigoration of Progenitor-Exhausted CD8 T Cells by anti-CTLA-4 Contributes to the Sustained Activity of Combination Checkpoint Blockade Open
View article: Additional file 4 of Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes
Additional file 4 of Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes Open
Additional file 4: Table S3. RNA-seq and scRNA-seq estimated expression profiles for cell mixtures and cell lines.
View article: Additional file 6 of Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes
Additional file 6 of Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes Open
Additional file 6: Table S5. Predicted abundance and clinical annotations of pediatric AML and neuroblastoma TARGET patients that were used to evaluate the outcomes-predictive value of subclone abundances in diagnostic samples.
View article: Additional file 3 of Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes
Additional file 3 of Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes Open
Additional file 3: Table S2. Cell-type specific biomarkers for cell lines used in the 6 cell mixtures.
View article: Effective methods for bulk RNA-Seq deconvolution using scnRNA-Seq transcriptomes
Effective methods for bulk RNA-Seq deconvolution using scnRNA-Seq transcriptomes Open
RNA profiling technologies at single-cell resolutions, including single-cell and single-nuclei RNA sequencing (scRNA-Seq and snRNA-Seq, scnRNA-Seq for short), can help characterize the composition of tissues and reveal cells that influence…
View article: Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas Open
View article: Multi-Clonal Live SARS-CoV-2 In Vitro Neutralization by Antibodies Isolated from Severe COVID-19 Convalescent Donors
Multi-Clonal Live SARS-CoV-2 In Vitro Neutralization by Antibodies Isolated from Severe COVID-19 Convalescent Donors Open
The interactions between antibodies, SARS-CoV-2 and immune cells contribute to the pathogenesis of COVID-19 and protective immunity. To understand the differences between antibody responses in mild versus severe cases of COVID-19, we analy…
View article: Heterogeneity of CD4+ T Cells
Heterogeneity of CD4+ T Cells Open
CD4+ T cells, which consist of T helper cells and T regulatory cells (Tregs) are indispensable for adaptive immunity. T helper cells are key positive regulators of both the humoral and cellular immune responses to infections, whereas Tregs…
View article: Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR
Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR Open
View article: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR
Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR Open