Evgeny Nimerovsky
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View article: Self-assembled cellulosic superstructures with unanticipated high quantum yields
Self-assembled cellulosic superstructures with unanticipated high quantum yields Open
Nonconventional luminophores devoid of traditional, large π-conjugates often suffer from low solid-state fluorescence quantum yields (FLQYs). In parallel, self-assembled bowl-shaped and helical architectures at the micro- and macroscale ar…
View article: Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation
Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation Open
Alzheimer’s disease is a specific neurodegenerative disorder, distinct from normal aging, with a growing unmet medical need. It is characterized by the accumulation of amyloid plaques in the brain, primarily consisting of amyloid beta (Aβ)…
View article: Reversible Self‐Assembly of Monosaccharide‐Based Nanoparticles With Reversible Fluorescence Modulation
Reversible Self‐Assembly of Monosaccharide‐Based Nanoparticles With Reversible Fluorescence Modulation Open
Reversible self‐assembly of nanoparticles remains challenging due to limited molecular mobility. Moreover, reported successful examples typically rely on inorganic‐core nanoparticles that require surface pre‐functionalization with specific…
View article: The Structure of Human IAPP Fibrils Reflects Membrane and pH Conditions
The Structure of Human IAPP Fibrils Reflects Membrane and pH Conditions Open
Physiologically relevant in vitro models of amyloid aggregation are essential for linking structural insights to disease pathology. In type 2 diabetes, aggregation of human islet amyloid polypeptide (hIAPP) into fibrils is a hallmark of β-…
View article: The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation.
The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation. Open
Alzheimer’s disease is a specific neurodegenerative disorder, distinct from normal aging, with a growing unmet medical need. It is characterized by the accumulation of amyloid plaques in the brain, primarily consisting of amyloid beta (Aβ)…
View article: Pseudo rotary resonance relaxation dispersion effects in isotropic samples
Pseudo rotary resonance relaxation dispersion effects in isotropic samples Open
Enhanced transverse relaxation near rotary resonance conditions is a well-documented effect for anisotropic solid samples undergoing magic-angle spinning (MAS). We report transverse signal decay associated with rotary resonance conditions …
View article: The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation
The clinical drug candidate anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation Open
Alzheimer’s disease is a specific neurodegenerative disorder, distinct from normal aging, with a growing unmet medical need. It is characterized by the accumulation of amyloid plaques in the brain, primarily consisting of amyloid beta (Aβ)…
View article: Lipidic folding pathway of α-Synuclein via a toxic oligomer
Lipidic folding pathway of α-Synuclein via a toxic oligomer Open
Aggregation intermediates play a pivotal role in the assembly of amyloid fibrils, which are central to the pathogenesis of neurodegenerative diseases. The structures of filamentous intermediates and mature fibrils are now efficiently deter…
View article: Analysis of the MODIST Sequence for Selective Proton–Proton Recoupling
Analysis of the MODIST Sequence for Selective Proton–Proton Recoupling Open
Theoretical and simulated analyses of selective homonuclear dipolar recoupling sequences serve as primary tools for understanding and determining the robustness of these sequences under various conditions. In this article, we investigate t…
View article: Pseudo Rotary Resonance Relaxation Dispersion Effects in Isotropic Samples
Pseudo Rotary Resonance Relaxation Dispersion Effects in Isotropic Samples Open
Enhanced transverse relaxation near rotary-resonance conditions is a well-documented effect for anisotropic solid samples undergoing magic-angle spinning (MAS). It is a surprising behavior for rotating liquids, in which first-order anisotr…
View article: Seeing Double: The Persistent Dimer‐of‐Dimers Structure of Drug Resistant Influenza A M2
Seeing Double: The Persistent Dimer‐of‐Dimers Structure of Drug Resistant Influenza A M2 Open
The currently circulating S31N variant of the M2 proton channel of influenza A is resistant to antiviral drugs. Recently, there has been a growing concern regarding the impact of the lipid environment on the structural features of the S31N…
View article: Homonuclear Simplified Preservation of Equivalent Pathways Spectroscopy
Homonuclear Simplified Preservation of Equivalent Pathways Spectroscopy Open
Recently developed homonuclear transverse mixing optimal control pulses (hTROP) revealed an elegant way to enhance the detected signal in multidimensional magic-angle spinning (MAS) nuclear magnetic resonance experiments. Inspired by their…
View article: Lipidic folding pathway of α-Synuclein via a toxic oligomer
Lipidic folding pathway of α-Synuclein via a toxic oligomer Open
Aggregation intermediates play a pivotal role in the assembly of amyloid fibrils, which are central to the pathogenesis of neurodegenerative diseases1,2. The structures of filamentous intermediates3 and mature fibrils4 are now efficiently …
View article: Seeing double: the persistent dimer-of-dimers structure of drug resistant influenza A M2
Seeing double: the persistent dimer-of-dimers structure of drug resistant influenza A M2 Open
The currently circulating S31N variant of the M2 proton channel of influenza A is resistant to antiviral drugs. Recently, there has been a growing concern regarding the impact of the lipid environment on the structural features of the S31N…
View article: Mobility of sodium ions in agarose gels probed through combined single- and triple-quantum NMR
Mobility of sodium ions in agarose gels probed through combined single- and triple-quantum NMR Open
Funder: \n http://dx.doi.org/10.13039/501100001659\n Deutsche Forschungsgemeinschaft
View article: Homonuclear Simplified Preservation of Equivalent Pathways Spectroscopy
Homonuclear Simplified Preservation of Equivalent Pathways Spectroscopy Open
Recently developed homonuclear Transverse mixing Optimal control Pulses (hTROP) revealed an elegant way to enhance the detected signal in multi-dimensional magic-angle spinning (MAS) NMR experiments. Inspired by their work, we present two …
View article: Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal
Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal Open
Decades of previous efforts to develop renal-sparing polyene antifungals were misguided by the classic membrane permeabilization model1. Recently, the clinically vital but also highly renal-toxic small-molecule natural product amphotericin…
View article: Simplified Preservation of Equivalent Pathways Spectroscopy
Simplified Preservation of Equivalent Pathways Spectroscopy Open
Inspired by the recently proposed transverse mixing optimal control pulses (TROP) approach for improving signal in multidimensional magic-angle spinning (MAS) NMR experiments, we present simplified preservation of equivalent pathways spect…
View article: Simplified Preservation of Equal Paths Spectroscopy
Simplified Preservation of Equal Paths Spectroscopy Open
Inspired by the recently proposed Transverse mixing Optimal control Pulses (TROP) approach for improving signal in multi-dimensional magic-angle spinning (MAS) NMR experiments, we present simplified preservation of equal paths spectroscopy…
View article: Simplified Preservation of Equal Pathways Solid Element
Simplified Preservation of Equal Pathways Solid Element Open
The files contain the raw data of the experiments shown in the article: "Simple Preservation of Equal Pathways Solid Element".
View article: Simplified Preservation of Equal Pathways Solid Element
Simplified Preservation of Equal Pathways Solid Element Open
The files contain the raw data of the experiments shown in the article: "Simple Preservation of Equal Pathways Solid Element".
View article: Great Offset Difference Internuclear Selective Transfer
Great Offset Difference Internuclear Selective Transfer Open
Carbon-carbon dipolar recoupling sequences are frequently used building blocks in routine magic-angle spinning NMR experiments. While broadband homonuclear first-order dipolar recoupling sequences mainly excite intra-residue correlations, …
View article: Anle138b interaction in α-synuclein aggregates by dynamic nuclear polarization NMR
Anle138b interaction in α-synuclein aggregates by dynamic nuclear polarization NMR Open
Small molecules that bind to oligomeric protein species such as membrane proteins and fibrils are of clinical interest for development of therapeutics and diagnostics. Definition of the binding site at atomic resolution via NMR is often ch…
View article: Windowed cross polarization at 55 kHz magic-angle spinning
Windowed cross polarization at 55 kHz magic-angle spinning Open
Cross polarization (CP) transfers via Hartmann-Hahn matching conditions are one of the cornerstones of solid-state magic-angle spinning NMR experiments. Here we investigate a windowed sequence for cross polarization (wCP) at 55 kHz magic-a…
View article: Modest Offset Difference Internuclear Selective Transfer via Homonuclear Dipolar Coupling
Modest Offset Difference Internuclear Selective Transfer via Homonuclear Dipolar Coupling Open
Homonuclear dipolar recoupling is routinely used for magic-angle spinning NMR-based structure determination. In fully protonated samples, only short proton-proton distances are accessible to broadband recoupling approaches because of high …
View article: Backbone Torsion Angle Determination Using Proton Detected Magic-Angle Spinning Nuclear Magnetic Resonance
Backbone Torsion Angle Determination Using Proton Detected Magic-Angle Spinning Nuclear Magnetic Resonance Open
[Image: see text] Protein torsion angles define the backbone secondary structure of proteins. Magic-angle spinning (MAS) NMR methods using carbon detection have been developed to measure torsion angles by determining the relative orientati…