Evi Lim
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View article: Region-specific distribution of transversal-axial tubule system organization underlies heterogeneity of calcium dynamics in the right atrium
Region-specific distribution of transversal-axial tubule system organization underlies heterogeneity of calcium dynamics in the right atrium Open
Mouse and human atrial myocardium demonstrate high variability in the organization of the transversal-axial tubule system (TATS), with more organized TATS expressed in the right atrial appendage. TATS distribution governs anatomical hetero…
View article: Long QT Syndrome <i>KCNH2</i> Variant Induces hERG1a/1b Subunit Imbalance in Patient-Specific Induced Pluripotent Stem Cell–Derived Cardiomyocytes
Long QT Syndrome <i>KCNH2</i> Variant Induces hERG1a/1b Subunit Imbalance in Patient-Specific Induced Pluripotent Stem Cell–Derived Cardiomyocytes Open
Background: Inherited long QT syndrome type 2 results from variants in the KCNH2 gene encoding the human Ether-à-go-go related gene 1 (hERG1) potassium channel. Two main isoforms, hERG1a and hERG1b, assemble to form tetrameric channel. The…
View article: Caveolin-3 is required for regulation of transient outward potassium current by angiotensin II in mouse atrial myocytes
Caveolin-3 is required for regulation of transient outward potassium current by angiotensin II in mouse atrial myocytes Open
Angiotensin II receptor 1 is associated with caveolae and caveolar scaffolding protein caveolin-3 in mouse atrial myocytes that is required for the regulation of I to by angiotensin II. Downregulation of caveolae/caveolin-3 disrupts this r…
View article: Caveolae‐Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis
Caveolae‐Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis Open
Background Atrial fibrillation often occurs in the setting of hypertension and associated atrial dilation with pathologically increased cardiomyocyte stretch. In the setting of atrial dilation, mechanoelectric feedback has been linked to t…