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View article: Cerebellar Purkinje cell firing reduction contributes to aging-related declining motor coordination in mice
Cerebellar Purkinje cell firing reduction contributes to aging-related declining motor coordination in mice Open
Aging is associated with the decline of many bodily functions including motor coordination. Aging-related impairment in motor coordination can result in falls, which reduce independence, health span, and quality of life in the elderly. To …
View article: Interplay Between the Mineralocorticoid System, Inflammation, Hypertension, and Kidney Disease
Interplay Between the Mineralocorticoid System, Inflammation, Hypertension, and Kidney Disease Open
Aldosterone, produced by adrenal glomerulosa cells, stimulated by angiotensin II, adrenocorticotrophin, and potassium, and inhibited by natriuretic peptides, plays a role in hypertension and CKD development and progression. Its effects are…
View article: Mitochondrial damage and impaired mitophagy contribute to disease progression in SCA6
Mitochondrial damage and impaired mitophagy contribute to disease progression in SCA6 Open
Spinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease that manifests in midlife and progressively worsens with age. SCA6 is rare, and many patients are not diagnosed until long after disease onset. Whether disease-causing cel…
View article: Structured connectivity in the output of the cerebellar cortex
Structured connectivity in the output of the cerebellar cortex Open
Circuits in the brain are built from connections between neurons, where the spatial organization and functional properties of these connections determines circuit function. In the cerebellum, Purkinje cells transmit information to neurons …
View article: Activation of TrkB-Akt signaling rescues deficits in a mouse model of SCA6
Activation of TrkB-Akt signaling rescues deficits in a mouse model of SCA6 Open
Spinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease resulting in motor coordination deficits and cerebellar pathology. Expression of brain-derived neurotrophic factor (BDNF) is reduced in postmortem tissue from SCA6 patient…
View article: 4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors
4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors Open
Recent studies have demonstrated that selective activation of mammalian target of rapamycin complex 1 (mTORC1) in the cerebellum by deletion of the mTORC1 upstream repressors TSC1 or phosphatase and tensin homolog (PTEN) in Purkinje cells …
View article: Restoration of BDNF-TrkB signaling rescues deficits in a mouse model of SCA6
Restoration of BDNF-TrkB signaling rescues deficits in a mouse model of SCA6 Open
Spinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease resulting in motor coordination deficits and cerebellar pathology. Expression of brain-derived neurotrophic factor (BDNF) is reduced in several neurodegenerative diseases,…
View article: Losing the Beat: Contribution of Purkinje Cell Firing Dysfunction to Disease, and Its Reversal
Losing the Beat: Contribution of Purkinje Cell Firing Dysfunction to Disease, and Its Reversal Open
The cerebellum is a brain structure that is highly interconnected with other brain regions. There are many contributing factors to cerebellar-related brain disease, such as altered afferent input, local connectivity, and/or cerebellar outp…